Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson's disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson's disease

• Published in: BMC neurology Vol. 24; no. 1; p. 94
• Main Authors: Jin, Hong, Du, Yiheng, Yan, Jiahui, Zhang, Jinru, Cheng, Xiaoyu, Mao, Chengjie, Chen, Jing, Liu, Chun-Feng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12-03-2024; BioMed Central; BMC
• Subjects: Age; Bladder; Care and treatment; Clinical characteristics; Cognitive ability; Cohort Studies; Complications and side effects; Diagnosis; Disease; Dopa; Dopamine; Dosage and administration; Dyskinesia; Dyskinesias; Follow-Up Studies; Health aspects; Humans; Movement disorders; Neurodegenerative diseases; Nocturia; Overactive bladder; Parkinson Disease - complications; Parkinson Disease - epidemiology; Parkinson's disease; Pathogenesis; Pathophysiology; Patients; Quality of life; Regression analysis; Risk factors; Therapeutic targets; Urinary Bladder, Overactive - diagnosis; Urinary Bladder, Overactive - drug therapy; Urinary Bladder, Overactive - epidemiology; Urinary incontinence; Urogenital system; China; Clinical characteristics; Overactive bladder; Parkinson's disease; Dyskinesia
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-024-03578-3

Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson's disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose of this study was to examine the relationship between dyskinesia, OAB, and clinical characteristics among individuals with PD.
1338 PD patients were included in the present study. Demographic features were compared between patients with or without dyskinesia and OAB symptoms. Logistic regression was conducted on dyskinesia to screen clinically relevant factors. Overactive Bladder Symptom Score (OABSS) was further used to stratify the association between the severity of OAB and the occurrence of dyskinesia.
This study indicates that both dyskinesia and OAB are significantly related to disease severity and cognitive status. PD patients with dyskinesia and OAB having higher UPDRS scores (p < 0.001), H-Y scores (p < 0.001), NMSQ (p < 0.001) and MoCA scores (p < 0.001), and lower MMSE scores (p < 0.001) are identified. The multivariate logistic regression confirms that disease duration (p = 0.041), LEDD (p < 0.001), UPDRSII (p < 0.001), MoCA (p = 0.024), urgency (p < 0.001), frequency (p < 0.001), and nocturia (p = 0.002) are independent risk factors for dyskinesia. Trend analysis indicates that the risk of dyskinesia significantly increases when patients exhibit moderate to severe OAB symptoms (OABSS > 5) (p < 0.001). No significant interactions were found between OABSS and age, gender, disease duration, LEDD, and NMSQ scores in different subgroups, indicating that dyskinesia is more pronounced in patients with OABSS > 5.
This study provides compelling evidence supporting the strong correlation between OAB and dyskinesia in PD patients, emphasizing the presence of shared pathogenic mechanisms between these two conditions. Our findings underscore the importance of considering both OAB and dyskinesia in the clinical management of PD, investigating the intricate connections between OAB and dyskinesia could unveil valuable insights into the complex pathophysiology of PD and potentially identify novel therapeutic targets for more effective PD treatment strategies.