Carbonic Anhydrase II Is a Tumor Vessel Endothelium–Associated Antigen Targeted by Dendritic Cell Therapy

Tumor-associated antigens are promising candidates as target molecules for immunotherapy and a wide variety of tumor-associated antigens have been discovered through the presence of serum antibodies in cancer patients. We previously conducted dendritic cell therapy on 10 malignant melanoma patients...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 11; no. 22; pp. 8201 - 8207
Main Authors:	YOSHIURA, Kenta, NAKAOKA, Takashi, IMAJOH-OHMI, Shinobu, OYAIZU, Naoki, YAMASHITA, Naohide, NISHISHITA, Toshihide, SATO, Katsuaki, YAMAMOTO, Akifumi, SHIMADA, Shinji, SAIDA, Toshiaki, KAWAKAMI, Yutaka, TAKAHASHI, Tsuneo A, FUKUDA, Hiroyuki
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-11-2005
Subjects:	Adult Aged Amino Acid Sequence Antibodies, Neoplasm - blood Antigens, Neoplasm - chemistry Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Carbonic Anhydrase II - chemistry Carbonic Anhydrase II - genetics Carbonic Anhydrase II - immunology Cell Line Cell Line, Tumor Dendritic Cells - immunology Dendritic Cells - transplantation Electrophoresis, Gel, Two-Dimensional Endothelial Cells - enzymology Endothelial Cells - physiology Endothelium, Vascular - immunology Female Gene Expression Regulation, Enzymologic Humans Immunohistochemistry Immunotherapy, Adoptive - methods Male Medical sciences Melanoma - immunology Melanoma - pathology Melanoma - therapy Melanoma/skin cancers Middle Aged Molecular Sequence Data Molecular Weight Neovascularization, Physiologic - physiology Pharmacology. Drug treatments Proteomics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tumor Angiogenesis and Microcirculation Tumor antigens Tumor immunobiology Dendritic cell Cell therapy Enzyme Lyases Malignant tumor Endothelium Antigen Antigen presenting cell Blood vessel Carbonate dehydratase Circulatory system Target cell Carbon-oxygen lyases Hydro-lyases
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