Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium

Recent reports have shown that cyclosporine (CsA)-treated patients have abundant calcineurin phosphatase (CN) activity in vivo despite CsA blood concentrations that would be completely inhibitory in vitro. We sought to determine whether this disparity was a result of altered distribution of CsA in c...

Full description

Saved in:

Bibliographic Details
Published in:	Transplantation Vol. 61; no. 1; pp. 158 - 161
Main Authors:	BATIUK, T. D, PAZDERKA, F, ENNS, J, DE CASTRO, L, HALLORAN, P. F
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott 1996
Subjects:	Biological and medical sciences Calcineurin Calmodulin-Binding Proteins - metabolism Cells, Cultured Culture Media Cyclosporine - pharmacology Humans Immunomodulators Interferon-gamma - biosynthesis Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Medical sciences Pharmacology. Drug treatments Phosphoprotein Phosphatases - metabolism Culture medium Cell culture Leukocyte Immunosuppressive agent Blood culture In vitro Biological activity Blood
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!