Long-term outcomes of malignant phyllodes tumors patients: an institutional experience

• Published in: The American journal of surgery Vol. 192; no. 4; pp. 492 - 495
• Main Authors: Fou, Adora, Schnabel, Freya R., Hamele-Bena, Diane, Wei, Xiao-Jun, Cheng, Bin, El Tamer, Mahmoud, Klein, Laura, Joseph, Kathie Ann
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-10-2006; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Biological and medical sciences; Breast cancer; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Cystosarcoma phyllodes; Cysts; Ethnicity; Female; Follow-Up Studies; General aspects; Gynecology. Andrology. Obstetrics; Histology; Humans; Hyperplasia; Malignant phyllodes tumors; Mammary gland diseases; Mastectomy; Medical sciences; Metastasis; Middle Aged; Mitotic Index; Mortality; Neoplasm Invasiveness; Phyllodes Tumor - mortality; Phyllodes Tumor - secondary; Phyllodes Tumor - therapy; Phyllodes tumors; Retrospective Studies; Surgery; Survival Rate; Treatment Outcome; Tumors; Malignant phyllodes tumors; Cystosarcoma phyllodes; Breast cancer; Phyllodes tumors; Human; Prognosis; Patient; Institution; Malignant tumor; Long term; Medicine; Mammary gland diseases; Treatment; Surgery; Evolution; Mammary gland; Phyllode tumor
• DOI: 10.1016/j.amjsurg.2006.06.017
• EISSN: 1879-1883
• ISSN: 0002-9610

Malignant phyllodes tumors are an extremely rare breast tumor. Prognostic features and overall survival data have not been consistent across studies.
Retrospectively, we examined the clinicopathologic features of 27 breast cancer patients treated for malignant phyllodes tumors from 1995 to 2004 and analyzed their recurrence and survival outcomes using contingency tables, a logistic regression model, or a proportional hazard model.
The mortality rate was 12% (n = 3) of the cohort and 75% of the group with distant metastases. The median follow-up period was 51 months (range, 12–192 mo). A mitotic index greater than 10 per high-powered field, the presence of stromal overgrowth, mastectomy at initial surgery, and larger tumor size were associated with an increased incidence of distant metastases. Larger tumor size also was associated with an increased incidence of death.
Most patients with malignant phyllodes tumors will enjoy significant long-term survival if treated appropriately with local excision with clear margins.