Tau inhibits PKA by nuclear proteasome‐dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation

Intraneuronal accumulation of wild‐type tau plays a key role in Alzheimer's disease, while the mechanisms underlying tauopathy and memory impairment remain unclear. Here, we report that overexpressing full‐length wild‐type human tau (hTau) in mouse hippocampus induces learning and memory defici...

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Bibliographic Details
Published in:	Aging cell Vol. 19; no. 1; pp. e13055 - n/a
Main Authors:	Ye, Jinwang, Yin, Yaling, Liu, Huanhuan, Fang, Lin, Tao, Xiaoqing, Wei, Linyu, Zuo, Yue, Yin, Ying, Ke, Dan, Wang, Jian‐Zhi
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01-01-2020 John Wiley and Sons Inc
Subjects:	Alzheimer's disease Brain-derived neurotrophic factor Cognitive ability CREB CREB-Binding Protein - metabolism Cyclic adenylic acid Cyclic AMP response element-binding protein Cyclic AMP-Dependent Protein Kinases - drug effects Dephosphorylation GluA1 Humans Kinases Memory mRNA Neurodegenerative diseases Neuronal Plasticity - genetics Original PA28γ Phosphorylation PKA proteasome Proteasome activator Protein binding Protein kinase A Protein kinases Proteins RNA Signal Transduction Synapses - metabolism synaptic plasticity Tau Tau protein tau Proteins - metabolism TrkB receptors proteasome CREB PKA PA28γ Tau GluA1 synaptic plasticity
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