Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases

Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases

Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal rhythms, and antioxidant and anti-inflammatory effects. It also possesses the ability to modulate immune responses by regulation of the T helpe...

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Published in:International Journal of Molecular Sciences Vol. 14; no. 6; pp. 11742 - 11766
Main Authors: Lin, Gu-Jiun, Huang, Shing-Hwa, Chen, Shyi-Jou, Wang, Chih-Hung, Chang, Deh-Ming, Sytwu, Huey-Kang
Format: Journal Article Book Review
Language:English
Published: Switzerland MDPI AG 31-05-2013
Molecular Diversity Preservation International (MDPI)
Subjects:
Animals
autoimmune disease
Autoimmune Diseases - drug therapy
Autoimmune Diseases - etiology
Clinical Trials as Topic
Disease Models, Animal
Humans
Inflammation - drug therapy
Inflammation - etiology
inflammatory bowel disease
melatonin
Melatonin - biosynthesis
Melatonin - therapeutic use
multiple sclerosis
Review
rheumatoid arthritis
systemic lupus erythematosus
type 1 diabetes mellitus
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Abstract Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal rhythms, and antioxidant and anti-inflammatory effects. It also possesses the ability to modulate immune responses by regulation of the T helper 1/2 balance and cytokine production. Autoimmune diseases, which result from the activation of immune cells by autoantigens released from normal tissues, affect around 5% of the population. Activation of autoantigen-specific immune cells leads to subsequent damage of target tissues by these activated cells. Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis. This review summarizes and highlights the role and the modulatory effects of melatonin in several inflammatory autoimmune diseases including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, and inflammatory bowel disease.
AbstractList Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal rhythms, and antioxidant and anti-inflammatory effects. It also possesses the ability to modulate immune responses by regulation of the T helper 1/2 balance and cytokine production. Autoimmune diseases, which result from the activation of immune cells by autoantigens released from normal tissues, affect around 5% of the population. Activation of autoantigen-specific immune cells leads to subsequent damage of target tissues by these activated cells. Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis. This review summarizes and highlights the role and the modulatory effects of melatonin in several inflammatory autoimmune diseases including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, and inflammatory bowel disease.
Author Sytwu, Huey-Kang
Huang, Shing-Hwa
Lin, Gu-Jiun
Chen, Shyi-Jou
Chang, Deh-Ming
Wang, Chih-Hung
AuthorAffiliation 7 Department of Microbiology and Immunology, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan
4 Department of Pediatrics, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan
6 Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan
2 Department of General Surgery, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan; E-Mail: doc20333@yahoo.com.tw
8 Rheumatology/Immunology/Allergy, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan; E-Mail: ming0503@ms3.hinet.net
5 Department of Otolaryngology—Head and Neck Surgery, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan
1 Department of Biology and Anatomy, National Defense Medical Center, No. 1
AuthorAffiliation_xml – name: 4 Department of Pediatrics, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan
– name: 3 Graduate Institute of Medical Sciences, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan; E-Mails: pedneuchen@hotmail.com (S.-J.C.); chw@ms3.hinet.net (C.-H.W.)
– name: 6 Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan
– name: 1 Department of Biology and Anatomy, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan; E-Mail: lingujiun@mail.ndmctsgh.edu.tw
– name: 5 Department of Otolaryngology—Head and Neck Surgery, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan
– name: 2 Department of General Surgery, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan; E-Mail: doc20333@yahoo.com.tw
– name: 7 Department of Microbiology and Immunology, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan
– name: 8 Rheumatology/Immunology/Allergy, Tri-Service General Hospital, No.325, Section 2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan; E-Mail: ming0503@ms3.hinet.net
Author_xml – sequence: 1
  givenname: Gu-Jiun
  surname: Lin
  fullname: Lin, Gu-Jiun
  email: sytwu@ndmctsgh.edu.tw
  organization: Department of Biology and Anatomy, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan. sytwu@ndmctsgh.edu.tw
– sequence: 2
  givenname: Shing-Hwa
  surname: Huang
  fullname: Huang, Shing-Hwa
– sequence: 3
  givenname: Shyi-Jou
  surname: Chen
  fullname: Chen, Shyi-Jou
– sequence: 4
  givenname: Chih-Hung
  surname: Wang
  fullname: Wang, Chih-Hung
– sequence: 5
  givenname: Deh-Ming
  surname: Chang
  fullname: Chang, Deh-Ming
– sequence: 6
  givenname: Huey-Kang
  surname: Sytwu
  fullname: Sytwu, Huey-Kang
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23727938$$D View this record in MEDLINE/PubMed
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Snippet Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal...
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StartPage 11742
SubjectTerms Animals
autoimmune disease
Autoimmune Diseases - drug therapy
Autoimmune Diseases - etiology
Clinical Trials as Topic
Disease Models, Animal
Humans
Inflammation - drug therapy
Inflammation - etiology
inflammatory bowel disease
melatonin
Melatonin - biosynthesis
Melatonin - therapeutic use
multiple sclerosis
Review
rheumatoid arthritis
systemic lupus erythematosus
type 1 diabetes mellitus
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Title Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases
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