Vaccine-derived varicella zoster infection in a kidney transplant recipient after zoster vaccine live administration

• Published in: Vaccine Vol. 37; no. 27; pp. 3576 - 3579
• Main Authors: Ortiz-Brizuela, Edgar, Leal-Vega, Francisco, Cuellar-Rodríguez, Jennifer, Bobadilla-del-Valle, Miriam, Ponce-de-León, Alfredo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 12-06-2019; Elsevier Limited
• Subjects: Acyclovir; Allergy and Immunology; Blood; Chicken pox; Conflicts of interest; Family medical history; Herpes zoster; Immunization; Infections; Intravenous administration; Kidney transplantation; Kidney transplants; Kidneys; Open reading frames; Patients; Pneumonia; Polymerase chain reaction; Population; Shingles; Shingrix; Skin; Solid organ transplantation; Transplants & implants; Vaccines; Varicella; Zostavax; Zoster vaccine; United States > US; Mexico; Germany; Shingrix; Herpes zoster; Shingles; Zostavax; Solid organ transplantation; Zoster vaccine; Kidney transplantation
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2019.05.017

AbstractA 49-year-old kidney transplant recipient, presented with a skin rash, and interstitial infiltrates three weeks after receiving a live attenuated varicella-zoster vaccine. Varicella-zoster Oka-vaccine strain was detected in plasma by polymerase chain reaction and sequencing analysis targeting open reading frame 62 (ORF 62). She was treated successfully with intravenous acyclovir. Our case report supports the current contraindication of live attenuated varicella-zoster vaccine in the solid-organ transplant recipients. Recombinant subunit varicella-zoster vaccine may be the vaccine of choice in these patients; nevertheless, further information is required to establish its safety, efficacy, and optimal timing.