Blockade of cell adhesion molecules enhances cell engraftment in a murine model of liver cell transplantation

Abstract Aim OLT is the best alternative for patients with end-stage liver diseases. However, as the need for organs surpasses donor availability, alternatives to OLT are required. LCT could be a useful option versus OLT in several patients even though its low cell-engraftment hampers its efficiency...

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Bibliographic Details
Published in:	Transplant immunology Vol. 35; pp. 7 - 11
Main Authors:	Alfaro, Javier, Pérez, Dolores, Jiménez, Carlos, Serrano, Manuel, Martínez-Flores, José Ángel, Grau, Montserrat, Sánchez-Zapardiel, Elena, Paz-Artal, Estela, Serrano, Antonio
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-03-2016
Subjects:	Adhesion molecules Allergy and Immunology Allografts Animals Antibodies - pharmacology Disease Models, Animal End Stage Liver Disease - immunology End Stage Liver Disease - therapy Engraftment Graft Survival - drug effects Graft Survival - immunology Human Umbilical Vein Endothelial Cells - immunology Humans Integrin beta3 - immunology Intercellular Adhesion Molecule-1 - immunology Liver - immunology Liver cell transplantation Male Mice Stem Cell Transplantation Vascular patency orthotropic liver transplantation intercellular adhesion molecule I embryonic stem cells MoAb Vascular patency LT ICAM-1 CT cell transplantation OLT liver cell transplantation human umbilical vein endothelial cells Engraftment Adhesion molecules LCT liver transplantation HUVECs ESCs monoclonal antibodies Liver cell transplantation
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