Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor-α (TNF-α) in Bone Loss of Patients with Rheumatoid Arthritis

• Published in: International journal of rheumatology Vol. 2020; pp. 9149762 - 7
• Main Authors: Ginting, Andi Raga, Hidayat, Rudy, Sumariyono, Sumariyono, Koesnoe, Sukamto
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2020; Hindawi Limited
• Subjects: Cytokines; Gene expression; Inflammation; Laboratories; Metabolism; Necrosis; Rheumatoid arthritis; Rheumatology; Studies; Tumor necrosis factor-TNF; Womens health; India
• ISSN: 1687-9260; 1687-9279
• DOI: 10.1155/2020/9149762

Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis. TNF-α is the main inflammatory cytokine that can directly increase bone resorption. However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor. This study examines the correlation between TNF-α and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA. This study found that 60.6% of the patients were in remission or low disease activity. The median of TNF-α was 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml. There is positive correlation between TNF-α and P1NP (r=0.363, p=0.026), also between SFRP-1 and P1NP (r=0.341; p=0.036). A low level of TNF-𝛼, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA.