Skin grafts from genetically modified α-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts

Highlights • GalT-KO porcine skin grafts functionally equivalent to allogeneic grafts. • Control of fluid-loss, and wound infection rates comparable. • No significant difference in healing of subsequent definitive autografts. • Grafts tolerate freeze–thaw process well, facilitating storage and trans...

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Bibliographic Details
Published in:	Burns Vol. 43; no. 8; pp. 1717 - 1724
Main Authors:	Leonard, D.A, Mallard, C, Albritton, A, Torabi, R, Mastroianni, M, Sachs, D.H, Kurtz, J.M, Cetrulo, C.L
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-12-2017
Subjects:	Allogeneic skin Animals Animals, Genetically Modified Burns - surgery Critical Care Disease Models, Animal Galactosyltransferases - genetics GalT-KO Papio Skin - pathology Skin Transplantation - methods Split-thickness skin graft Swine Swine, Miniature Temporary burn wound closure Transplantation, Heterologous Wound Healing - physiology Wound Infection Xenogeneic skin Temporary burn wound closure Split-thickness skin graft Xenogeneic skin GalT-KO Allogeneic skin
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Summary:	Highlights • GalT-KO porcine skin grafts functionally equivalent to allogeneic grafts. • Control of fluid-loss, and wound infection rates comparable. • No significant difference in healing of subsequent definitive autografts. • Grafts tolerate freeze–thaw process well, facilitating storage and transport.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributed equally to this study.
ISSN:	0305-4179 1879-1409 1879-1409
DOI:	10.1016/j.burns.2017.04.026