Longitudinal and Temporal Associations Between Daily Pain and Sleep Patterns After Major Pediatric Surgery

• Published in: The journal of pain Vol. 18; no. 6; p. 656
• Main Authors: Rabbitts, Jennifer A, Zhou, Chuan, Narayanan, Arthi, Palermo, Tonya M
• Format: Journal Article
• Language: English
• Published: United States 01-06-2017
• Subjects: Actigraphy; Adolescent; Child; Female; Humans; Linear Models; Longitudinal Studies; Male; Medical Records; Pain Measurement; Pain, Postoperative - complications; Pain, Postoperative - physiopathology; Self Report; Sleep - physiology; Sleep Wake Disorders - complications; Sleep Wake Disorders - physiopathology; Spine - surgery; Thoracic Wall - surgery; Time Factors; Postoperative pain; pediatric pain; spine fusion; scoliosis surgery; perioperative sleep
• ISSN: 1528-8447
• DOI: 10.1016/j.jpain.2017.01.004

Approximately 20% of children develop persistent pain after major surgery. Sleep disruption has been implicated as a predictor of children's acute postsurgical pain. However, perioperative sleep patterns have not been longitudinally assessed, and the role of sleep in persistence of postsurgical pain has not been explored. We aimed to examine sleep patterns over 4 months in children having major surgery, and temporal relationships between daily sleep and pain. Sixty children age 10 to 18 (mean = 14.7) years having major surgery completed 7 days of actigraphy sleep monitoring (sleep duration, efficiency), twice daily electronic diaries (sleep quality, pain intensity, medication use), and validated questionnaires at presurgery, 2 weeks, and 4 months postsurgery. Generalized linear models, controlling for age, sex, naps, and medication, showed sleep quality (β [B] = -.88, P < .001) and efficiency (B = -1.50, P = .036) were significantly reduced at 2 weeks compared with presurgery, and returned to baseline by 4 months. Poorer night-time sleep quality was significantly associated with greater next day pain intensity (B = -.15, P = .005). Sleep duration and efficiency were not associated with subsequent pain; daytime pain was not associated with subsequent sleep. Findings suggest sleep quality may be an important target for intervention after surgery in children; research is needed to understand how other sleep parameters may relate to recovery.
This study assessed longitudinal sleep patterns over 4 months after major pediatric surgery using actigraphy, diaries, and validated measures. Sleep quality and efficiency were significantly reduced at 2 weeks. Poorer sleep quality was associated with greater next day pain intensity suggesting that sleep quality may be an important target for intervention.