Prediction of the PCDD/F and dl-PCB 2005-WHO-TEQ content based on the contribution of six congeners: Toward a new screening approach for fish samples?

• Published in: Environmental pollution (1987) Vol. 158; no. 3; pp. 941 - 947
• Main Authors: Cariou, Ronan, Marchand, Philippe, Vénisseau, Anaïs, Brosseaud, Aline, Bertrand, Dominique, Qannari, El Mostafa, Antignac, Jean-Philippe, Le Bizec, Bruno
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01-03-2010; Elsevier
• Subjects: Animals; Benzofurans - chemistry; Biological and medical sciences; chemical analysis; Congeners; Cost analysis; Dibenzofurans, Polychlorinated; Environmental Pollutants - chemistry; Fish; Fishes; Food Contamination - analysis; Food toxicology; Gas chromatography; Gas Chromatography-Mass Spectrometry - methods; Isomerism; Life Sciences; Mass spectrometry; Mathematical models; Medical sciences; PCDD/F; Polychlorinated biphenyl; polychlorinated biphenyls; Polychlorinated Biphenyls - chemistry; polychlorinated dibenzodioxins; Polychlorinated Dibenzodioxins - analogs & derivatives; Polychlorinated Dibenzodioxins - chemistry; polychlorinated dibenzofurans; prediction; regression analysis; Regression model; risk assessment; Screening; Seafood - analysis; Statistical methods; statistical models; toxicity testing; Toxicology; Toxicology and food chain; European Union; Screening; PCDD/F; Fish; Regression model; Polychlorinated biphenyl; Edible fish; Polychlorobiphenyls; Concentration; Forecast model; Assay; Pollutant; Food; Quantitative analysis; Chemical contamination; FISH; REGRESSION MODEL; SCREENING; POLYCHLORINATED BIPHENYL
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2009.09.010

Current European Union regulation regarding polychlorinated dibenzo-
p-dioxins, polychlorinated dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in food and feed is based on Toxic Equivalent Quotient (TEQ) concept. For confirmatory purpose, the isotope-dilution method associated to a measurement by gas chromatography coupled with high resolution mass spectrometry is usually the method of choice for precisely measuring the 29 target congeners in three separated fractions. Time and cost related to these analyses are very significant. Various kinds of screening concepts can be considered. In the present study, we elaborated and validated a prediction model for the 2005 World Health Organization TEQ in fish, based on the measurement of 4 PCDD/F and 2 non-ortho dl-PCB congeners, potentially analyzable in a single extracted fraction by gas chromatography coupled with mass spectrometry. Large independent datasets have been used for model elaboration (
n = 108) and validation (
n = 363,
n = 357 and
n = 6).
This study describes a statistical regression model approach for screening PCDD/Fs and dl-PCBs in fish.