No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status

• Published in: Journal of applied physiology (1985) Vol. 88; no. 5; pp. 1571 - 1575
• Main Authors: Rankinen, Tuomo, Wolfarth, Bernd, Simoneau, Jean-Aime, Maier-Lenz, Dirk, Rauramaa, Rainer, Rivera, Miguel A, Boulay, Marcel R, Chagnon, Yvon C, Perusse, Louis, Keul, Joseph, Bouchard, Claude
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01-05-2000; American Physiological Society
• Subjects: Alleles; Anatomy & physiology; Athletes; Biological and medical sciences; Cohort Studies; DNA Transposable Elements; Enzymes; Fundamental and applied biological sciences. Psychology; Gene Deletion; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Human; Humans; Male; Men; Oxygen Consumption; Peptidyl-Dipeptidase A - genetics; Physical Endurance - physiology; Polymorphism, Genetic - genetics; Population genetics, reproduction patterns; Reference Values; Sports; Sports training; Human; Physical performance; Enzyme; Insertion; Athlete; Genetic determinism; Population genetics; Peptidases; Allele; Sport; Peptidyl-dipeptidase A; Deletion; Hydrolases; Peptidyl-dipeptidases; Endurance; Polymorphism
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.2000.88.5.1571

1  Pennington Biomedical Research Center, Human
Genomics Laboratory, Baton Rouge, Louisiana 70808-4124;
2  Department of Prevention, Rehabilitation,
and Sports Medicine, University of Freiburg, 79106 Freiburg, Germany;
3  Physical Activity Sciences Laboratory, Laval
University, Ste-Foy, Québec G1K 7P4; Canada;
4  Kuopio Research Institute of Exercise Medicine,
Department of Physiology, University of Kuopio, and Department of
Clinical Physiology and Nuclear Medicine, Kuopio University Hospital,
70100 Kuopio, Finland; and 5  Department of
Physiology and Department of Physical Medicine, Rehabilitation, and
Sports Medicine, University of Puerto Rico School of Medicine, San
Juan, Puerto Rico 00936
Several
studies have reported that the insertion (I) allele of the
angiotensin-converting enzyme ( ACE ) I/deletion (D) polymorphism is associated with enhanced responsiveness to endurance training and is
more common in endurance athletes than in sedentary controls. We tested
the latter hypothesis in a cohort of 192 male endurance athletes with
maximal oxygen uptake 75
ml · kg 1 · min 1
and 189 sedentary male controls. The ACE ID polymorphism in
intron 16 was typed with the three-primer polymerase chain reaction
method. Both the genotype ( P  = 0.214) and allele
( P  = 0.095) frequencies were similar in the athletes and the
controls. Further analyses in the athletes revealed no excess of the I
allele among the athletes within the highest quartile (> 80 ml · kg 1 · min 1 )
or decile (>83
ml · kg 1 · min 1 )
of maximal oxygen uptake. These data from the GENATHLETE cohort do
not support the hypothesis that the ACE ID polymorphism is associated with a higher cardiorespiratory endurance performance level.
genetics; sports; endurance performance; insertion/deletion
 Deceased 27 August 1999.