Polymer Enzyme Conjugates as Chiral Ligands for Sharpless Dihydroxylation of Alkenes in Organic Solvents
Conjugates of enzymes and poly(2‐methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantios...
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| Published in: | Chembiochem : a European journal of chemical biology Vol. 16; no. 1; pp. 83 - 90 |
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| Language: | English |
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Weinheim
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02-01-2015
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| Abstract | Conjugates of enzymes and poly(2‐methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantioselectivity. The highest selectivities, found for osmate complexed with laccase polymer–enzyme conjugates (PECs), even exceed those of classical Sharpless catalysts.
Count Os in: We report organosoluble artificial metalloenzymes, generated from poly(2‐methyl‐oxazoline) enzyme conjugates and osmate as a promising new catalytic system for the dihydroxylation of alkenes in organic media. |
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| AbstractList | Conjugates of enzymes and poly(2‐methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantioselectivity. The highest selectivities, found for osmate complexed with laccase polymer–enzyme conjugates (PECs), even exceed those of classical Sharpless catalysts.
Count Os in: We report organosoluble artificial metalloenzymes, generated from poly(2‐methyl‐oxazoline) enzyme conjugates and osmate as a promising new catalytic system for the dihydroxylation of alkenes in organic media. Conjugates of enzymes and poly(2-methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantioselectivity. The highest selectivities, found for osmate complexed with laccase polymer-enzyme conjugates (PECs), even exceed those of classical Sharpless catalysts. |
| Author | Tiller, Joerg C. Konieczny, Stefan Leurs, Melanie |
| Author_xml | – sequence: 1 givenname: Stefan surname: Konieczny fullname: Konieczny, Stefan organization: Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Strasse 66, 44227 Dortmund (Germany) – sequence: 2 givenname: Melanie surname: Leurs fullname: Leurs, Melanie organization: Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Strasse 66, 44227 Dortmund (Germany) – sequence: 3 givenname: Joerg C. surname: Tiller fullname: Tiller, Joerg C. email: joerg.tiller@tu-dortmund.de organization: Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Strasse 66, 44227 Dortmund (Germany) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25421303$$D View this record in MEDLINE/PubMed |
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| Keywords | organic solvents asymmetric catalysis Sharpless dihydroxylation polymer enzyme conjugates artificial metalloenzymes |
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| Snippet | Conjugates of enzymes and poly(2‐methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the... Conjugates of enzymes and poly(2-methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the... |
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| SubjectTerms | Alkenes - chemistry artificial metalloenzymes asymmetric catalysis Biocatalysis Chymotrypsin - chemistry Enzymes Fungal Proteins - chemistry Hydroxylation Laccase - chemistry Ligands Lipase - chemistry Muramidase - chemistry organic solvents Oxazoles - chemistry Peroxidase - chemistry polymer enzyme conjugates Polymers - chemistry Sharpless dihydroxylation Solvents Stereoisomerism |
| Title | Polymer Enzyme Conjugates as Chiral Ligands for Sharpless Dihydroxylation of Alkenes in Organic Solvents |
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