GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo

GNA13 is the most frequently mutated gene in germinal center (GC)-derived B-cell lymphomas, including nearly a quarter of Burkitt lymphoma and GC-derived diffuse large B-cell lymphoma. These mutations occur in a pattern consistent with loss of function. We have modeled the GNA13-deficient state excl...

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Bibliographic Details
Published in:	Blood Vol. 127; no. 22; pp. 2723 - 2731
Main Authors:	Healy, Jane A., Nugent, Adrienne, Rempel, Rachel E., Moffitt, Andrea B., Davis, Nicholas S., Jiang, Xiaoyu, Shingleton, Jennifer R., Zhang, Jenny, Love, Cassandra, Datta, Jyotishka, McKinney, Matthew E., Tzeng, Tiffany J., Wettschureck, Nina, Offermanns, Stefan, Walzer, Katelyn A., Chi, Jen-Tsan, Rasheed, Suhail A.K., Casey, Patrick J., Lossos, Izidore S., Dave, Sandeep S.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 02-06-2016 American Society of Hematology
Subjects:	Animals B-Lymphocytes - metabolism B-Lymphocytes - pathology Germinal Center - metabolism Germinal Center - pathology GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism Lymphoid Neoplasia Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Male Mice Mice, Knockout Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics
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