Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations

Objective To identify clinicopathological differences between frontotemporal lobar degeneration (FTLD) due to mutations in progranulin (FTLD‐GRN) and chromosome 9 open reading frame 72 (FTLD‐C9ORF72). Methods We performed quantitative neuropathologic comparison of 17 FTLD‐C9ORF72 and 15 FTLD‐GRN wit...

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Bibliographic Details
Published in:	Annals of clinical and translational neurology Vol. 6; no. 9; pp. 1782 - 1796
Main Authors:	Sakae, Nobutaka, Roemer, Shanu F., Bieniek, Kevin F., Murray, Melissa E., Baker, Matthew C., Kasanuki, Koji, Graff‐Radford, Neill R., Petrucelli, Leonard, Van Blitterswijk, Marka, Rademakers, Rosa, Dickson, Dennis W.
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-09-2019 John Wiley and Sons Inc Wiley
Subjects:	Aged Aged, 80 and over Apraxia Atrophy Brain Brain - metabolism Brain - pathology C9orf72 Protein - genetics Female Frontotemporal Lobar Degeneration - genetics Frontotemporal Lobar Degeneration - metabolism Frontotemporal Lobar Degeneration - pathology Humans Male Microglia - metabolism Microglia - pathology Middle Aged Morphology Motor neurone disease Mutation Neurodegeneration Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neuropathology Pathogenesis Progranulins - genetics Studies tau Proteins - metabolism
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