Grade and laterality of intraventricular haemorrhage to predict 18-22 month neurodevelopmental outcomes in extremely low birthweight infants

• Published in: Acta Paediatrica Vol. 101; no. 4; pp. 414 - 418
• Main Authors: Merhar, Stephanie L, Tabangin, Meredith E, Meinzen-Derr, Jareen, Schibler, Kurt R
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-04-2012; Blackwell; Wiley Subscription Services, Inc
• Subjects: Babies; Bacterial diseases; Bacterial sepsis; Bayley; Biological and medical sciences; Birth weight; Cognitive; Developmental Disabilities - etiology; Developmental Disabilities - physiopathology; Female; Follow-Up Studies; General aspects; Human bacterial diseases; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - physiopathology; Infectious diseases; Intracranial Hemorrhages - complications; Intracranial Hemorrhages - pathology; Intracranial Hemorrhages - physiopathology; Male; Medical sciences; Motor; Multivariate Analysis; Nervous System Diseases - etiology; Nervous System Diseases - physiopathology; Premature; Prognosis; Sepsis; Severity of Illness Index; Steroids; Time Factors; Human; Premature; Steroid; Psychomotor development; Pediatrics; Hemispheric specialization; Motor; Prediction; Infant; Bayley; Cognition; Cerebral ventricle; Extremely low birthweight; Hemorrhage; Bacteremia; Infection; Sepsis syndrome; Prematurity; Bacteriosis; Sepsis; Cognitive; Predictive factor; Laterality; Steroids
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2011.02584.x

Aim:  To determine whether extremely low‐birthweight (ELBW) infants with bilateral compared to unilateral intraventricular haemorrhage (IVH) have worse neurodevelopmental outcomes at 18–22 months.
Methods:  A total of 166 ELBW infants (<1000 g) admitted to a Cincinnati NICU from 1998 to 2005 with a head ultrasound showing Grade I–IV IVH and neurodevelopmental assessment at 18–22 months corrected age were included. Multivariable linear and logistic regression models were developed to determine the impact of laterality and grade of IVH and other clinical variables to predict scores on the Bayley Scales of Infant Development, Second Edition, Mental Development Index and Psychomotor Development Index and the combined outcome of neurodevelopmental impairment (NDI).
Results:  Infants with bilateral grade IV IVH had lower adjusted mean Bayley scores compared with infants with unilateral grade IV IVH. For grades I, II and III IVH, bilaterality of IVH was not associated with lower mean Bayley scores. Infants with grade IV IVH had the highest odds of NDI. The probability of NDI increased with sepsis and postnatal steroid use.
Conclusion:  ELBW infants with bilateral compared to those with unilateral grade IV IVH had worse neurodevelopmental outcomes. Infants with grades I–III IVH had similar outcomes whether they had unilateral or bilateral IVH.