Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines
Intranasal inactivated influenza vaccines can elicit mucosal immune responses that protect against virus infection. For the development of intranasal inactivated influenza vaccines, effective adjuvants inducing minimal adverse reactions are required. Generally, however, lower toxicity adjuvants have...
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| Published in: | RSC advances Vol. 8; no. 30; pp. 16527 - 16536 |
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| Main Authors: | , , , , , , , , , , , , , |
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Royal Society of Chemistry
01-01-2018
The Royal Society of Chemistry |
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| Abstract | Intranasal inactivated influenza vaccines can elicit mucosal immune responses that protect against virus infection. For the development of intranasal inactivated influenza vaccines, effective adjuvants inducing minimal adverse reactions are required. Generally, however, lower toxicity adjuvants have lower adjuvanticity. In this research, we fabricated nanoparticle-based adjuvants to enhance its adjuvanticity. Herein, we focused on low-molecular-weight polyinosinic-polycytidylic acid, referred to as uPIC(40:400), as a weak and less toxic RNA adjuvant. We conjugated uPIC(40:400) with different shaped gold nanoparticles (AuNPs) electrostatically. Conjugation with gold nanorods, but not spherical AuNPs, markedly enhanced the adjuvanticity of uPIC(40:400), leading to the suppression of viral infection in mice. Notably, conjugation with gold nanorods did not increase the inflammatory cytokine production in dendritic cells. These data indicated that gold nanorods can provide a good platform for enhancing the weak adjuvanticity of uPIC(40:400) while maintaining low inflammatory cytokine production toward the development of intranasal inactivated influenza vaccines. |
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| AbstractList | Intranasal inactivated influenza vaccines can elicit mucosal immune responses that protect against virus infection. For the development of intranasal inactivated influenza vaccines, effective adjuvants inducing minimal adverse reactions are required. Generally, however, lower toxicity adjuvants have lower adjuvanticity. In this research, we fabricated nanoparticle-based adjuvants to enhance its adjuvanticity. Herein, we focused on low-molecular-weight polyinosinic-polycytidylic acid, referred to as uPIC(40:400), as a weak and less toxic RNA adjuvant. We conjugated uPIC(40:400) with different shaped gold nanoparticles (AuNPs) electrostatically. Conjugation with gold nanorods, but not spherical AuNPs, markedly enhanced the adjuvanticity of uPIC(40:400), leading to the suppression of viral infection in mice. Notably, conjugation with gold nanorods did not increase the inflammatory cytokine production in dendritic cells. These data indicated that gold nanorods can provide a good platform for enhancing the weak adjuvanticity of uPIC(40:400) while maintaining low inflammatory cytokine production toward the development of intranasal inactivated influenza vaccines. Intranasal inactivated influenza vaccines can elicit mucosal immune responses that protect against virus infection. For the development of intranasal inactivated influenza vaccines, effective adjuvants inducing minimal adverse reactions are required. Generally, however, lower toxicity adjuvants have lower adjuvanticity. In this research, we fabricated nanoparticle-based adjuvants to enhance its adjuvanticity. Herein, we focused on low-molecular-weight polyinosinic-polycytidylic acid, referred to as uPIC(40:400), as a weak and less toxic RNA adjuvant. We conjugated uPIC(40:400) with different shaped gold nanoparticles (AuNPs) electrostatically. Conjugation with gold nanorods, but not spherical AuNPs, markedly enhanced the adjuvanticity of uPIC(40:400), leading to the suppression of viral infection in mice. Notably, conjugation with gold nanorods did not increase the inflammatory cytokine production in dendritic cells. These data indicated that gold nanorods can provide a good platform for enhancing the weak adjuvanticity of uPIC(40:400) while maintaining low inflammatory cytokine production toward the development of intranasal inactivated influenza vaccines. Conjugation with gold nanorods enhanced the adjuvanticity of RNA adjuvant for intranasal inactivated influenza vaccines, providing efficient protection against infection in mice. |
| Author | Tabata, Koshiro Suzuki, Tadaki Ninomiya, Takafumi Niikura, Kenichi Ijiro, Kuniharu Kobayashi, Shintaro Orba, Yasuko Ohara, Yuki Nakano, Tetsuo Sawa, Hirofumi Tazaki, Taiyu Hasegawa, Hideki Mitomo, Hideyuki Ainai, Akira |
| Author_xml | – sequence: 1 givenname: Taiyu surname: Tazaki fullname: Tazaki, Taiyu organization: Graduate School of Chemical Sciences and Engineering, Hokkaido University Sapporo 060-8628 Japan – sequence: 2 givenname: Koshiro surname: Tabata fullname: Tabata, Koshiro email: tksuzuki@nih.go.jp organization: Department of Pathology, National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan tksuzuki@nih.go.jp – sequence: 3 givenname: Akira surname: Ainai fullname: Ainai, Akira email: tksuzuki@nih.go.jp organization: Department of Pathology, National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan tksuzuki@nih.go.jp – sequence: 4 givenname: Yuki surname: Ohara fullname: Ohara, Yuki email: tksuzuki@nih.go.jp organization: Department of Pathology, National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan tksuzuki@nih.go.jp – sequence: 5 givenname: Shintaro surname: Kobayashi fullname: Kobayashi, Shintaro organization: Research Center for Zoonosis Control, Hokkaido University Sapporo 001-0020 Japan – sequence: 6 givenname: Takafumi surname: Ninomiya fullname: Ninomiya, Takafumi organization: School of Medicine, Sapporo Medical University Sapporo 060-8556 Japan – sequence: 7 givenname: Yasuko surname: Orba fullname: Orba, Yasuko organization: Research Center for Zoonosis Control, Hokkaido University Sapporo 001-0020 Japan – sequence: 8 givenname: Hideyuki orcidid: 0000-0002-6748-7816 surname: Mitomo fullname: Mitomo, Hideyuki organization: Global Station for Soft Matter, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University Sapporo 001-0021 Japan – sequence: 9 givenname: Tetsuo orcidid: 0000-0001-8324-2109 surname: Nakano fullname: Nakano, Tetsuo organization: Graduate School of Agriculture, Hokkaido University Sapporo 060-8589 Japan – sequence: 10 givenname: Hideki surname: Hasegawa fullname: Hasegawa, Hideki email: tksuzuki@nih.go.jp organization: Department of Pathology, National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan tksuzuki@nih.go.jp – sequence: 11 givenname: Kuniharu surname: Ijiro fullname: Ijiro, Kuniharu organization: Global Station for Soft Matter, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University Sapporo 001-0021 Japan – sequence: 12 givenname: Hirofumi orcidid: 0000-0003-2569-2755 surname: Sawa fullname: Sawa, Hirofumi organization: Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University Sapporo 001-0020 Japan – sequence: 13 givenname: Tadaki surname: Suzuki fullname: Suzuki, Tadaki email: tksuzuki@nih.go.jp organization: Department of Pathology, National Institute of Infectious Diseases Toyama 1-23-1, Shinjuku-ku Tokyo 162-8640 Japan tksuzuki@nih.go.jp – sequence: 14 givenname: Kenichi orcidid: 0000-0002-2874-4920 surname: Niikura fullname: Niikura, Kenichi email: niikura.kenichi@nit.ac.jp organization: Department of Innovative Systems Engineering, Nippon Institute of Technology 4-1 Gakuendai, Miyashiro-machi, Minamisaitama-gun Saitama 345-8501 Japan niikura.kenichi@nit.ac.jp |
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| Cites_doi | 10.1021/la049463z 10.1002/anie.201107304 10.1021/mp060096p 10.1021/ja808719p 10.1021/cm0492336 10.1073/pnas.0710779105 10.1016/j.vaccine.2013.11.069 10.1146/annurev-bioeng-071811-150124 10.1021/acsnano.5b02153 10.1007/BF02123572 10.1039/C5NR02970H 10.1016/S0022-1759(98)00204-X 10.1002/smll.201701815 10.1038/nri1184 10.1038/nmat2784 10.1016/j.vaccine.2015.09.072 10.1038/nri3247 10.1016/0264-410X(90)90053-O 10.1021/nn3057005 10.1002/path.2287 10.1111/j.1348-0421.1976.tb00911.x 10.1021/nl2030213 10.1021/nn203596e 10.1021/ar2000315 10.1016/j.vaccine.2017.08.034 10.2174/221270700201151216145746 10.4049/jimmunol.168.6.2930 10.1021/acs.langmuir.6b02064 10.1038/nri2691 10.1073/pnas.1305804110 10.1126/science.1155406 10.1021/nn901869f 10.1073/pnas.1502850112 10.1021/nn404211j 10.1074/jbc.M111.229120 10.1039/C8RA00033F 10.1126/science.1093373 10.1021/acsnano.6b07343 10.1021/acsnano.5b07716 10.1038/nri2868 10.1021/am505577j 10.1038/ncomms7280 10.1007/s11671-009-9334-6 10.1021/ja047846d 10.1021/nl070363y 10.1371/journal.pone.0092634 10.1016/j.jconrel.2011.03.009 10.1016/j.jconrel.2015.09.069 10.1016/0006-8993(86)91352-1 10.1021/acs.chemrev.5b00109 10.1128/JVI.79.5.2910-2919.2005 10.1039/C6SC03631G 10.1371/journal.pone.0130208 10.1021/nn3012114 10.1007/s00441-014-1848-2 10.1021/acs.chemrev.7b00194 10.1021/acsnano.5b08025 10.1021/acs.biomac.6b00027 10.1002/smll.201401707 |
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| References | Liu (C8RA01690A-(cit37)/*[position()=1]) 2014; 10 Gause (C8RA01690A-(cit19)/*[position()=1]) 2017; 11 Liu (C8RA01690A-(cit30)/*[position()=1]) 2017; 13 Leonard (C8RA01690A-(cit5)/*[position()=1]) 2008; 105 Choi (C8RA01690A-(cit11)/*[position()=1]) 2013; 110 Matsuo (C8RA01690A-(cit22)/*[position()=1]) 2011; 152 Tobita (C8RA01690A-(cit50)/*[position()=1]) 1975; 162 Liu (C8RA01690A-(cit6)/*[position()=1]) 2008; 320 Ikeda (C8RA01690A-(cit47)/*[position()=1]) 2015; 33 Mottram (C8RA01690A-(cit33)/*[position()=1]) 2007; 4 Aggarwal (C8RA01690A-(cit53)/*[position()=1]) 2003; 3 Nochi (C8RA01690A-(cit21)/*[position()=1]) 2010; 9 Giljohann (C8RA01690A-(cit10)/*[position()=1]) 2009; 131 Asanuma (C8RA01690A-(cit1)/*[position()=1]) 2015; 2 Sims (C8RA01690A-(cit57)/*[position()=1]) 2010; 10 Shiosaka (C8RA01690A-(cit13)/*[position()=1]) 1986; 382 Irvine (C8RA01690A-(cit17)/*[position()=1]) 2015; 115 Kanaya (C8RA01690A-(cit8)/*[position()=1]) 2014; 357 Dykman (C8RA01690A-(cit20)/*[position()=1]) 2017; 8 Zhang (C8RA01690A-(cit41)/*[position()=1]) 2015; 9 Liu (C8RA01690A-(cit18)/*[position()=1]) 2016; 10 Matsumoto (C8RA01690A-(cit56)/*[position()=1]) 2015; 6 Gole (C8RA01690A-(cit52)/*[position()=1]) 2004; 16 Zhou (C8RA01690A-(cit39)/*[position()=1]) 2016; 10 Lunov (C8RA01690A-(cit15)/*[position()=1]) 2011; 5 Lutz (C8RA01690A-(cit51)/*[position()=1]) 1999; 223 Hirabayashi (C8RA01690A-(cit46)/*[position()=1]) 1990; 8 Albanese (C8RA01690A-(cit26)/*[position()=1]) 2012; 14 Vigderman (C8RA01690A-(cit45)/*[position()=1]) 2012; 51 Bachmann (C8RA01690A-(cit35)/*[position()=1]) 2010; 10 Desmet (C8RA01690A-(cit4)/*[position()=1]) 2012; 12 Nambara (C8RA01690A-(cit29)/*[position()=1]) 2016; 32 Radovic-Moreno (C8RA01690A-(cit40)/*[position()=1]) 2015; 112 Uhl (C8RA01690A-(cit32)/*[position()=1]) 2018; 8 Chithrani (C8RA01690A-(cit23)/*[position()=1]) 2007; 7 Li (C8RA01690A-(cit27)/*[position()=1]) 2015; 7 Sun (C8RA01690A-(cit59)/*[position()=1]) 2013; 7 Niikura (C8RA01690A-(cit12)/*[position()=1]) 2014; 6 Sano (C8RA01690A-(cit2)/*[position()=1]) 2017; 35 Ji (C8RA01690A-(cit58)/*[position()=1]) 2012; 6 Kumar (C8RA01690A-(cit38)/*[position()=1]) 2015; 220 Sau (C8RA01690A-(cit44)/*[position()=1]) 2004; 20 Ichinohe (C8RA01690A-(cit3)/*[position()=1]) 2005; 79 Ainai (C8RA01690A-(cit42)/*[position()=1]) 2015; 10 Vácha (C8RA01690A-(cit24)/*[position()=1]) 2011; 11 Kinnear (C8RA01690A-(cit31)/*[position()=1]) 2017; 117 Asahi (C8RA01690A-(cit48)/*[position()=1]) 2002; 168 Satie (C8RA01690A-(cit55)/*[position()=1]) 2011; 286 Niikura (C8RA01690A-(cit36)/*[position()=1]) 2013; 7 Bradley (C8RA01690A-(cit54)/*[position()=1]) 2008; 214 Kusaka (C8RA01690A-(cit60)/*[position()=1]) 2014; 9 Perry (C8RA01690A-(cit25)/*[position()=1]) 2011; 44 Chen (C8RA01690A-(cit28)/*[position()=1]) 2016; 17 Sau (C8RA01690A-(cit43)/*[position()=1]) 2004; 126 Machida (C8RA01690A-(cit7)/*[position()=1]) 1976; 20 Hutter (C8RA01690A-(cit34)/*[position()=1]) 2010; 4 Zhao (C8RA01690A-(cit16)/*[position()=1]) 2014; 32 Stevens (C8RA01690A-(cit49)/*[position()=1]) 2004; 303 Chen (C8RA01690A-(cit14)/*[position()=1]) 2009; 4 |
| References_xml | – volume: 20 start-page: 6414 year: 2004 ident: C8RA01690A-(cit44)/*[position()=1] publication-title: Langmuir doi: 10.1021/la049463z contributor: fullname: Sau – volume: 51 start-page: 636 year: 2012 ident: C8RA01690A-(cit45)/*[position()=1] publication-title: Angew. Chem., Int. Ed. doi: 10.1002/anie.201107304 contributor: fullname: Vigderman – volume: 4 start-page: 73 year: 2007 ident: C8RA01690A-(cit33)/*[position()=1] publication-title: Mol. Pharm. doi: 10.1021/mp060096p contributor: fullname: Mottram – volume: 131 start-page: 2072 year: 2009 ident: C8RA01690A-(cit10)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja808719p contributor: fullname: Giljohann – volume: 16 start-page: 3633 year: 2004 ident: C8RA01690A-(cit52)/*[position()=1] publication-title: Chem. Mater. doi: 10.1021/cm0492336 contributor: fullname: Gole – volume: 105 start-page: 258 year: 2008 ident: C8RA01690A-(cit5)/*[position()=1] publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0710779105 contributor: fullname: Leonard – volume: 32 start-page: 327 year: 2014 ident: C8RA01690A-(cit16)/*[position()=1] publication-title: Vaccine doi: 10.1016/j.vaccine.2013.11.069 contributor: fullname: Zhao – volume: 14 start-page: 1 year: 2012 ident: C8RA01690A-(cit26)/*[position()=1] publication-title: Annu. Rev. Biomed. Eng. doi: 10.1146/annurev-bioeng-071811-150124 contributor: fullname: Albanese – volume: 9 start-page: 6465 year: 2015 ident: C8RA01690A-(cit41)/*[position()=1] publication-title: ACS Nano doi: 10.1021/acsnano.5b02153 contributor: fullname: Zhang – volume: 162 start-page: 9 year: 1975 ident: C8RA01690A-(cit50)/*[position()=1] publication-title: Med. Microbiol. Immunol. doi: 10.1007/BF02123572 contributor: fullname: Tobita – volume: 7 start-page: 16631 year: 2015 ident: C8RA01690A-(cit27)/*[position()=1] publication-title: Nanoscale doi: 10.1039/C5NR02970H contributor: fullname: Li – volume: 223 start-page: 77 year: 1999 ident: C8RA01690A-(cit51)/*[position()=1] publication-title: J. Immunol. Methods doi: 10.1016/S0022-1759(98)00204-X contributor: fullname: Lutz – volume: 13 start-page: 1701815 year: 2017 ident: C8RA01690A-(cit30)/*[position()=1] publication-title: Small doi: 10.1002/smll.201701815 contributor: fullname: Liu – volume: 3 start-page: 745 year: 2003 ident: C8RA01690A-(cit53)/*[position()=1] publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1184 contributor: fullname: Aggarwal – volume: 9 start-page: 572 year: 2010 ident: C8RA01690A-(cit21)/*[position()=1] publication-title: Nat. Mater. doi: 10.1038/nmat2784 contributor: fullname: Nochi – volume: 33 start-page: 6066 year: 2015 ident: C8RA01690A-(cit47)/*[position()=1] publication-title: Vaccine doi: 10.1016/j.vaccine.2015.09.072 contributor: fullname: Ikeda – volume: 12 start-page: 479 year: 2012 ident: C8RA01690A-(cit4)/*[position()=1] publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3247 contributor: fullname: Desmet – volume: 8 start-page: 243 year: 1990 ident: C8RA01690A-(cit46)/*[position()=1] publication-title: Vaccine doi: 10.1016/0264-410X(90)90053-O contributor: fullname: Hirabayashi – volume: 7 start-page: 3926 year: 2013 ident: C8RA01690A-(cit36)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn3057005 contributor: fullname: Niikura – volume: 214 start-page: 149 year: 2008 ident: C8RA01690A-(cit54)/*[position()=1] publication-title: J. Pathol. doi: 10.1002/path.2287 contributor: fullname: Bradley – volume: 20 start-page: 71 year: 1976 ident: C8RA01690A-(cit7)/*[position()=1] publication-title: Jpn. J. Microbiol. doi: 10.1111/j.1348-0421.1976.tb00911.x contributor: fullname: Machida – volume: 11 start-page: 5391 year: 2011 ident: C8RA01690A-(cit24)/*[position()=1] publication-title: Nano Lett. doi: 10.1021/nl2030213 contributor: fullname: Vácha – volume: 5 start-page: 9648 year: 2011 ident: C8RA01690A-(cit15)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn203596e contributor: fullname: Lunov – volume: 44 start-page: 990 year: 2011 ident: C8RA01690A-(cit25)/*[position()=1] publication-title: Acc. Chem. Res. doi: 10.1021/ar2000315 contributor: fullname: Perry – volume: 35 start-page: 5388 year: 2017 ident: C8RA01690A-(cit2)/*[position()=1] publication-title: Vaccine doi: 10.1016/j.vaccine.2017.08.034 contributor: fullname: Sano – volume: 2 start-page: 13 year: 2015 ident: C8RA01690A-(cit1)/*[position()=1] publication-title: Clin. Immunol., Endocr. Metab. Drugs doi: 10.2174/221270700201151216145746 contributor: fullname: Asanuma – volume: 168 start-page: 2930 year: 2002 ident: C8RA01690A-(cit48)/*[position()=1] publication-title: J. Immunol. doi: 10.4049/jimmunol.168.6.2930 contributor: fullname: Asahi – volume: 32 start-page: 12559 year: 2016 ident: C8RA01690A-(cit29)/*[position()=1] publication-title: Langmuir doi: 10.1021/acs.langmuir.6b02064 contributor: fullname: Nambara – volume: 10 start-page: 89 year: 2010 ident: C8RA01690A-(cit57)/*[position()=1] publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2691 contributor: fullname: Sims – volume: 110 start-page: 7625 year: 2013 ident: C8RA01690A-(cit11)/*[position()=1] publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1305804110 contributor: fullname: Choi – volume: 320 start-page: 379 year: 2008 ident: C8RA01690A-(cit6)/*[position()=1] publication-title: Science doi: 10.1126/science.1155406 contributor: fullname: Liu – volume: 4 start-page: 2595 year: 2010 ident: C8RA01690A-(cit34)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn901869f contributor: fullname: Hutter – volume: 112 start-page: 3892 year: 2015 ident: C8RA01690A-(cit40)/*[position()=1] publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1502850112 contributor: fullname: Radovic-Moreno – volume: 7 start-page: 10834 year: 2013 ident: C8RA01690A-(cit59)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn404211j contributor: fullname: Sun – volume: 286 start-page: 23280 year: 2011 ident: C8RA01690A-(cit55)/*[position()=1] publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.229120 contributor: fullname: Satie – volume: 8 start-page: 8089 year: 2018 ident: C8RA01690A-(cit32)/*[position()=1] publication-title: RSC Adv. doi: 10.1039/C8RA00033F contributor: fullname: Uhl – volume: 303 start-page: 1866 year: 2004 ident: C8RA01690A-(cit49)/*[position()=1] publication-title: Science doi: 10.1126/science.1093373 contributor: fullname: Stevens – volume: 11 start-page: 54 year: 2017 ident: C8RA01690A-(cit19)/*[position()=1] publication-title: ACS Nano doi: 10.1021/acsnano.6b07343 contributor: fullname: Gause – volume: 10 start-page: 2678 year: 2016 ident: C8RA01690A-(cit39)/*[position()=1] publication-title: ACS Nano doi: 10.1021/acsnano.5b07716 contributor: fullname: Zhou – volume: 10 start-page: 787 year: 2010 ident: C8RA01690A-(cit35)/*[position()=1] publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2868 contributor: fullname: Bachmann – volume: 6 start-page: 22146 year: 2014 ident: C8RA01690A-(cit12)/*[position()=1] publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/am505577j contributor: fullname: Niikura – volume: 6 start-page: 6280 year: 2015 ident: C8RA01690A-(cit56)/*[position()=1] publication-title: Nat. Commun. doi: 10.1038/ncomms7280 contributor: fullname: Matsumoto – volume: 4 start-page: 858 year: 2009 ident: C8RA01690A-(cit14)/*[position()=1] publication-title: Nanoscale Res. Lett. doi: 10.1007/s11671-009-9334-6 contributor: fullname: Chen – volume: 126 start-page: 8648 year: 2004 ident: C8RA01690A-(cit43)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja047846d contributor: fullname: Sau – volume: 7 start-page: 1542 year: 2007 ident: C8RA01690A-(cit23)/*[position()=1] publication-title: Nano Lett. doi: 10.1021/nl070363y contributor: fullname: Chithrani – volume: 9 start-page: e92634 year: 2014 ident: C8RA01690A-(cit60)/*[position()=1] publication-title: PLoS One doi: 10.1371/journal.pone.0092634 contributor: fullname: Kusaka – volume: 152 start-page: 310 year: 2011 ident: C8RA01690A-(cit22)/*[position()=1] publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2011.03.009 contributor: fullname: Matsuo – volume: 220 start-page: 141 year: 2015 ident: C8RA01690A-(cit38)/*[position()=1] publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2015.09.069 contributor: fullname: Kumar – volume: 382 start-page: 399 year: 1986 ident: C8RA01690A-(cit13)/*[position()=1] publication-title: Brain Res. doi: 10.1016/0006-8993(86)91352-1 contributor: fullname: Shiosaka – volume: 115 start-page: 11109 year: 2015 ident: C8RA01690A-(cit17)/*[position()=1] publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.5b00109 contributor: fullname: Irvine – volume: 79 start-page: 2910 year: 2005 ident: C8RA01690A-(cit3)/*[position()=1] publication-title: J. Virol. doi: 10.1128/JVI.79.5.2910-2919.2005 contributor: fullname: Ichinohe – volume: 8 start-page: 1719 year: 2017 ident: C8RA01690A-(cit20)/*[position()=1] publication-title: Chem. Sci. doi: 10.1039/C6SC03631G contributor: fullname: Dykman – volume: 10 start-page: e0130208 year: 2015 ident: C8RA01690A-(cit42)/*[position()=1] publication-title: PLoS One doi: 10.1371/journal.pone.0130208 contributor: fullname: Ainai – volume: 6 start-page: 5366 year: 2012 ident: C8RA01690A-(cit58)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn3012114 contributor: fullname: Ji – volume: 357 start-page: 279 year: 2014 ident: C8RA01690A-(cit8)/*[position()=1] publication-title: Cell Tissue Res. doi: 10.1007/s00441-014-1848-2 contributor: fullname: Kanaya – volume: 117 start-page: 11476 year: 2017 ident: C8RA01690A-(cit31)/*[position()=1] publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00194 contributor: fullname: Kinnear – volume: 10 start-page: 3589 year: 2016 ident: C8RA01690A-(cit18)/*[position()=1] publication-title: ACS Nano doi: 10.1021/acsnano.5b08025 contributor: fullname: Liu – volume: 17 start-page: 1205 year: 2016 ident: C8RA01690A-(cit28)/*[position()=1] publication-title: Biomacromolecules doi: 10.1021/acs.biomac.6b00027 contributor: fullname: Chen – volume: 10 start-page: 4505 year: 2014 ident: C8RA01690A-(cit37)/*[position()=1] publication-title: Small doi: 10.1002/smll.201401707 contributor: fullname: Liu |
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| Snippet | Intranasal inactivated influenza vaccines can elicit mucosal immune responses that protect against virus infection. For the development of intranasal... |
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| SubjectTerms | Adjuvants Chemistry Conjugation Cytokines Gold Influenza Molecular chains Nanoparticles Nanorods Ribonucleic acid RNA Toxicity Vaccines Viruses |
| Title | Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines |
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