Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

• Published in: Acta tropica Vol. 121; no. 2; pp. 152 - 155
• Main Authors: Storti-Melo, Luciane Moreno, da Costa, Daniela Reis, Souza-Neiras, Wanessa Christina, Cassiano, Gustavo Capatti, Couto, Vanja Suely Calvosa D’Almeida, Póvoa, Marinete Marins, Soares, Irene da Silva, de Carvalho, Luzia Helena, Arevalo-Herrera, Myrian, Herrera, Sócrates, Rossit, Andrea Regina Baptista, Cordeiro, José Antonio, de Mattos, Luiz Carlos, Machado, Ricardo Luiz Dantas
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01-02-2012; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; antibodies; Antibodies, Protozoan - blood; antibody formation; Antibody response; antigens; Antigens, Protozoan - immunology; at-risk population; Biological and medical sciences; Brazil; Enzyme-Linked Immunosorbent Assay; Gene Frequency; General aspects; HLA-DRB1; HLA-DRB1 Chains - genetics; HLA-DRB1 Chains - immunology; Humans; immunoglobulin G; Immunoglobulin G - blood; malaria; Malaria, Vivax - immunology; Medical sciences; merozoites; Middle Aged; patients; peptides; Plasmodium vivax; Plasmodium vivax - immunology; surface proteins; Brazil; South America; America; Plasmodium vivax; HLA-DRB1; Antibody response; Human; Infection; Protozoa; HLA-System; Apicomplexa; Allele; Antibody; Tropical medicine; Merozoite surface protein-1
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/j.actatropica.2011.10.009

We evaluated the influence of allelic frequency of the human leucocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil.
We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.