Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population

Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotyp...

Full description

Saved in:

Bibliographic Details
Published in:	Genome research Vol. 23; no. 10; pp. 1663 - 1674
Main Authors:	Schmitz, Robert J, He, Yupeng, Valdés-López, Oswaldo, Khan, Saad M, Joshi, Trupti, Urich, Mark A, Nery, Joseph R, Diers, Brian, Xu, Dong, Stacey, Gary, Ecker, Joseph R
Format:	Journal Article
Language:	English
Published:	United States Cold Spring Harbor Laboratory Press 01-10-2013
Subjects:	Arabidopsis - genetics Arabidopsis - metabolism BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Bisulfite Cell Division Chromosome Mapping Cytosine - metabolism DNA Methylation DNA Transposable Elements DNA, Plant - genetics DNA, Plant - metabolism DNA, Recombinant Epigenesis, Genetic Epigenomics Gene Expression Regulation, Plant Genes, Plant Genetic Variation Genetics & Heredity Genome, Plant Genotype Glycine max - genetics Glycine max - metabolism Inbreeding Polymorphism, Single Nucleotide Quantitative Trait Loci Sequence Analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were identified. Linkage mapping of methylation states assessed from whole-genome bisulfite sequencing of 83 RILs uncovered widespread evidence for local methylQTL. This epigenomics approach provides a comprehensive study of the patterns and heritability of methylation variants in a complex genetic population over multiple generations, paving the way for understanding how methylation variants contribute to phenotypic variation.
AbstractList	Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were identified. Linkage mapping of methylation states assessed from whole-genome bisulfite sequencing of 83 RILs uncovered widespread evidence for local methylQTL. This epigenomics approach provides a comprehensive study of the patterns and heritability of methylation variants in a complex genetic population over multiple generations, paving the way for understanding how methylation variants contribute to phenotypic variation.
Author	Nery, Joseph R Schmitz, Robert J Joshi, Trupti Urich, Mark A Valdés-López, Oswaldo Stacey, Gary He, Yupeng Xu, Dong Ecker, Joseph R Khan, Saad M Diers, Brian
Author_xml	– sequence: 1 givenname: Robert J surname: Schmitz fullname: Schmitz, Robert J organization: Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA – sequence: 2 givenname: Yupeng surname: He fullname: He, Yupeng – sequence: 3 givenname: Oswaldo surname: Valdés-López fullname: Valdés-López, Oswaldo – sequence: 4 givenname: Saad M surname: Khan fullname: Khan, Saad M – sequence: 5 givenname: Trupti surname: Joshi fullname: Joshi, Trupti – sequence: 6 givenname: Mark A surname: Urich fullname: Urich, Mark A – sequence: 7 givenname: Joseph R surname: Nery fullname: Nery, Joseph R – sequence: 8 givenname: Brian surname: Diers fullname: Diers, Brian – sequence: 9 givenname: Dong surname: Xu fullname: Xu, Dong – sequence: 10 givenname: Gary surname: Stacey fullname: Stacey, Gary – sequence: 11 givenname: Joseph R surname: Ecker fullname: Ecker, Joseph R
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23739894$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1625624$$D View this record in Osti.gov
BookMark	eNqNkctrFTEUxoNU7EOXbmVw5WZq3o-NIKUvKLjRrSGTe-beyEwyJrkt9783ZWqxO1fn9eM75_CdoqOYIiD0nuBzQjD5vM3nRFDBdCvpK3RCBDe94NIctRxr3RssyDE6LeUXxphxrd-gY8oUM9rwE_TzcglbiGmG_iFsoAtxBzlUFz10aez8oaYSInQz1N1hcjWk2N27HFyspcGd6zL4NA8htk5rDBk23ZKW_cq-Ra9HNxV49xTP0I-ry-8XN_3dt-vbi693vReE1d47rEAPUknDPFNOYk7AC66cV0R4QgZDFYWh3W3oIEa5ccxjMTAOIxNcszP0ZdVd9sMMGw-xZjfZJYfZ5YNNLtiXkxh2dpvuLVNaUcmawMdVIJUabPGhgt_5FCP4aomkQlLeoE9PW3L6vYdS7RyKh2lyEdK-WMKFFtRIrP8D5YxpoiVpaL-iPqdSMozPZxNsHz2222xXj1tJG__h31-f6b-msj-1Q6Ur
CitedBy_id	crossref_primary_10_3389_fpls_2015_00699 crossref_primary_10_1016_j_celrep_2023_112029 crossref_primary_10_1093_jxb_erw348 crossref_primary_10_1093_jxb_erw066 crossref_primary_10_1016_j_pbi_2023_102428 crossref_primary_10_1093_jxb_erz457 crossref_primary_10_1111_mec_13296 crossref_primary_10_1016_j_gene_2018_07_051 crossref_primary_10_1038_s41467_018_06932_5 crossref_primary_10_1371_journal_pone_0179821 crossref_primary_10_3390_plants12112170 crossref_primary_10_1270_jsbbs_19005 crossref_primary_10_1016_j_gene_2015_02_068 crossref_primary_10_1038_nplants_2015_222 crossref_primary_10_1093_mp_sst123 crossref_primary_10_7554_eLife_62202 crossref_primary_10_1080_15592294_2019_1625674 crossref_primary_10_1111_nph_14874 crossref_primary_10_3390_biology11070954 crossref_primary_10_1186_s13059_017_1206_2 crossref_primary_10_1038_nprot_2014_114 crossref_primary_10_1038_s41598_020_74520_z crossref_primary_10_1186_s12864_018_4874_8 crossref_primary_10_1093_dnares_dsy008 crossref_primary_10_1093_jxb_ert403 crossref_primary_10_3390_ijms19051414 crossref_primary_10_1186_s13059_018_1516_z crossref_primary_10_1093_gbe_evu271 crossref_primary_10_1186_s13059_016_1127_5 crossref_primary_10_1371_journal_pgen_1008872 crossref_primary_10_1515_bmc_2015_0005 crossref_primary_10_1038_s41467_018_02839_3 crossref_primary_10_1016_j_pbi_2014_01_002 crossref_primary_10_1038_nrg_2016_45 crossref_primary_10_1093_plphys_kiad668 crossref_primary_10_1096_fj_201900388R crossref_primary_10_1101_gr_183749_114 crossref_primary_10_1101_gr_256750_119 crossref_primary_10_3390_plants8050135 crossref_primary_10_1111_nph_16511 crossref_primary_10_1038_s41437_018_0095_9 crossref_primary_10_1111_nph_15388 crossref_primary_10_1093_gbe_evv194 crossref_primary_10_1371_journal_pgen_1004785 crossref_primary_10_1016_j_pbi_2013_11_017 crossref_primary_10_3389_fpls_2021_764999 crossref_primary_10_3390_ijms151223537 crossref_primary_10_1073_pnas_1716758114 crossref_primary_10_1146_annurev_phyto_080615_100156 crossref_primary_10_1007_s11738_018_2740_6 crossref_primary_10_1073_pnas_1607851113 crossref_primary_10_3390_ijms24065407 crossref_primary_10_1186_s13059_016_1059_0 crossref_primary_10_1016_j_pbi_2020_101989 crossref_primary_10_1111_pbi_12919 crossref_primary_10_3389_fmars_2018_00190 crossref_primary_10_1007_s10295_019_02218_x crossref_primary_10_1371_journal_pone_0165488 crossref_primary_10_1002_wsbm_1411 crossref_primary_10_3390_ijms22168618 crossref_primary_10_1093_nar_gkt905 crossref_primary_10_1016_j_plaphy_2019_09_044 crossref_primary_10_1146_annurev_genet_120215_035254 crossref_primary_10_1371_journal_pgen_1004813 crossref_primary_10_1016_j_molp_2018_02_006 crossref_primary_10_1038_s41598_017_12510_4 crossref_primary_10_1371_journal_pone_0105267 crossref_primary_10_1017_S1479262114000197 crossref_primary_10_1038_s41598_021_95054_y crossref_primary_10_1534_g3_120_401189 crossref_primary_10_1007_s00122_022_04122_y crossref_primary_10_1073_pnas_1515072113 crossref_primary_10_1186_s13059_017_1251_x crossref_primary_10_1016_j_bbagrm_2016_08_009 crossref_primary_10_1186_s13059_017_1254_7 crossref_primary_10_1038_srep40503 crossref_primary_10_3390_ijms21186849 crossref_primary_10_1093_nar_gkx020 crossref_primary_10_1016_j_pbi_2015_01_008 crossref_primary_10_1146_annurev_genet_120213_092443 crossref_primary_10_1146_annurev_genom_090413_025437 crossref_primary_10_1093_nsr_nwu003 crossref_primary_10_1111_mec_14107 crossref_primary_10_1093_jxb_eru120 crossref_primary_10_3389_fevo_2020_00004 crossref_primary_10_1093_nar_gkv738 crossref_primary_10_1534_g3_116_028324 crossref_primary_10_1016_j_semcdb_2015_08_010 crossref_primary_10_1007_s11427_022_2299_5 crossref_primary_10_1104_pp_114_235952 crossref_primary_10_1111_mec_13138 crossref_primary_10_1007_s11032_018_0875_1 crossref_primary_10_3389_fpls_2020_606800 crossref_primary_10_3390_life11010049 crossref_primary_10_1093_mp_sst165 crossref_primary_10_1038_s41574_018_0005_5 crossref_primary_10_1186_s12864_017_3962_5 crossref_primary_10_1002_csc2_20351 crossref_primary_10_1007_s12038_013_9388_6 crossref_primary_10_3390_agronomy12040838 crossref_primary_10_1038_nrg_2017_45 crossref_primary_10_1186_s13059_016_1032_y crossref_primary_10_1111_nph_14421 crossref_primary_10_1042_EBC20190032 crossref_primary_10_1073_pnas_1512995112 crossref_primary_10_3389_fpls_2021_692328 crossref_primary_10_1016_j_jgg_2024_01_006 crossref_primary_10_3390_f11080828 crossref_primary_10_1016_j_bcab_2017_11_006 crossref_primary_10_3389_fpls_2020_01284 crossref_primary_10_1371_journal_pone_0150002 crossref_primary_10_3389_fgene_2014_00341 crossref_primary_10_3389_fpls_2022_841154 crossref_primary_10_1007_s00425_023_04242_9 crossref_primary_10_1371_journal_pgen_1005724 crossref_primary_10_1016_j_tplants_2024_04_007 crossref_primary_10_3389_fpls_2015_00397 crossref_primary_10_1016_j_tplants_2017_04_009 crossref_primary_10_1186_1471_2164_15_299 crossref_primary_10_1093_dnares_dsx046 crossref_primary_10_3390_epigenomes3010004 crossref_primary_10_3389_fpls_2016_00447 crossref_primary_10_1111_jeb_13042 crossref_primary_10_1002_1438_390X_12018 crossref_primary_10_1038_s41467_018_03289_7 crossref_primary_10_3389_fpls_2023_1279231 crossref_primary_10_1371_journal_pone_0105338 crossref_primary_10_1093_plcell_koac197 crossref_primary_10_3390_biology10080766 crossref_primary_10_1105_tpc_114_126631 crossref_primary_10_3390_epigenomes4040025 crossref_primary_10_1111_mec_15131 crossref_primary_10_1038_ng_3886 crossref_primary_10_3389_fpls_2016_00455 crossref_primary_10_1111_nph_14418 crossref_primary_10_1186_s13059_017_1288_x crossref_primary_10_1093_dnares_dsv031 crossref_primary_10_3390_ijms19082315 crossref_primary_10_3390_ijms221910535 crossref_primary_10_1073_pnas_1515170112 crossref_primary_10_1186_s13059_015_0867_y crossref_primary_10_1093_plphys_kiad440 crossref_primary_10_1105_tpc_114_133025 crossref_primary_10_3389_fpls_2021_563953 crossref_primary_10_1016_j_molp_2015_01_021 crossref_primary_10_1371_journal_pgen_1004298 crossref_primary_10_3390_plants12234006 crossref_primary_10_1111_pbi_12449 crossref_primary_10_1080_15592294_2015_1107695 crossref_primary_10_1186_s12864_015_1668_0 crossref_primary_10_1371_journal_pgen_1005790 crossref_primary_10_1186_s12870_017_0997_3 crossref_primary_10_1073_pnas_1613623113 crossref_primary_10_1038_s41437_021_00441_w crossref_primary_10_1534_genetics_113_158980 crossref_primary_10_1111_nph_15579 crossref_primary_10_1038_srep41232 crossref_primary_10_1093_bfgp_elu003 crossref_primary_10_1093_dnares_dsy021 crossref_primary_10_1007_s13580_020_00310_1 crossref_primary_10_1016_j_pbi_2017_01_005
Cites_doi	10.3198/jpr2009.09.0546crg 10.1038/ng.715 10.1016/j.cell.2012.09.001 10.1371/journal.pgen.1000530 10.1093/bioinformatics/btp324 10.1105/tpc.111.094870 10.1126/science.1165313 10.1038/nature09798 10.1016/j.pbi.2012.09.001 10.1038/nature11968 10.1126/science.1186366 10.1073/pnas.1016884108 10.1126/science.1224839 10.1186/gb-2009-10-3-r25 10.1016/j.cell.2008.12.038 10.1093/bioinformatics/bth397 10.1038/nature10555 10.1016/j.tig.2012.10.012 10.1038/43657 10.1016/j.gde.2010.01.008 10.1038/nature06745 10.1126/science.1180677 10.1016/j.tplants.2012.01.001 10.1016/j.ympev.2005.11.018 10.1073/pnas.1019217108 10.1038/nature11532 10.1093/genetics/155.1.369 10.1007/s00122-005-1970-3 10.1038/35048692 10.1056/NEJMoa064522 10.1016/j.pbi.2011.03.010 10.1093/genetics/135.3.881 10.1073/pnas.1201043109 10.1073/pnas.1009695107 10.1371/journal.pgen.1003437 10.1093/molbev/msm088 10.1093/molbev/msm158 10.1600/036364409787602221 10.1105/tpc.109.072041 10.1371/journal.pbio.0050174 10.1073/pnas.1002720107 10.1534/genetics.111.128744 10.4161/fly.19695 10.1186/gb-2012-13-10-249 10.1371/journal.pgen.0020036 10.1093/bioinformatics/btg112 10.1038/ng1841 10.1105/tpc.109.069856 10.1038/ng.911 10.1104/pp.109.137935 10.1038/nrg2719 10.1073/pnas.1209329109 10.1126/science.1212959 10.1101/gad.524609 10.1093/bioinformatics/btp120 10.1021/cb300229q 10.1371/journal.pgen.1000032 10.1111/j.1365-313X.2007.03244.x 10.1073/pnas.1215380110 10.1104/pp.108.127902 10.1016/j.cell.2007.07.007 10.1111/j.1541-0420.2012.01825.x 10.1016/j.cell.2012.07.034 10.1016/j.cub.2011.12.054 10.1038/nature08670 10.1371/journal.pgen.1002372 10.1038/nature10414 10.1038/nrg1834 10.1016/j.cub.2003.11.052 10.1016/j.cell.2008.03.029 10.1101/gad.1512007 10.2135/cropsci2010.08.0459 10.4161/epi.4.2.8214 10.1016/0092-8674(95)90185-X 10.1038/nbt.1621 10.1073/pnas.1211757110 10.1126/science.273.5275.654 10.1105/tpc.112.106427 10.1101/gr.080200.108
ContentType	Journal Article
Copyright	2013
Copyright_xml	– notice: 2013
CorporateAuthor	Univ. of Missouri, Columbia, MO (United States)
CorporateAuthor_xml	– name: Univ. of Missouri, Columbia, MO (United States)
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7TM 8FD FR3 P64 RC3 OIOZB OTOTI 5PM
DOI	10.1101/gr.152538.112
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Nucleic Acids Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts OSTI.GOV - Hybrid OSTI.GOV PubMed Central (Full Participant titles)
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Genetics Abstracts Engineering Research Database Technology Research Database Nucleic Acids Abstracts Biotechnology and BioEngineering Abstracts
DatabaseTitleList	MEDLINE - Academic MEDLINE CrossRef Genetics Abstracts
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Chemistry Biology
DocumentTitleAlternate	Schmitz et al
EISSN	1549-5469
EndPage	1674
ExternalDocumentID	1625624 10_1101_gr_152538_112 23739894
Genre	Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: Howard Hughes Medical Institute grantid: GBMF3034 – fundername: NIGMS NIH HHS grantid: K99 GM100000 – fundername: NIGMS NIH HHS grantid: K99GM100000
GroupedDBID	--- .GJ 18M 29H 2WC 39C 4.4 53G 5GY 5RE 5VS AAYOK AAZTW ABDIX ABDNZ ACGFO ACYGS ADBBV ADNWM AEILP AENEX AI. ALMA_UNASSIGNED_HOLDINGS BAWUL BTFSW C1A CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HYE IH2 K-O KQ8 MV1 NPM R.V RCX RHF RHI RNS RPM RXW SJN TAE TR2 VH1 W8F WOQ YKV ZCG ZGI ZXP AAYXX CITATION 7X8 7TM 8FD FR3 P64 RC3 ABPTK ABRJW OIOZB OTOTI ZA5 5PM
ID	FETCH-LOGICAL-c513t-ca07e8b67693c37a6041ec547ac715c11b9272eb23792b5f6da3c05b34ef35483
IEDL.DBID	RPM
ISSN	1088-9051
IngestDate	Tue Sep 17 21:20:08 EDT 2024 Mon Jul 10 02:30:32 EDT 2023 Thu Oct 24 19:45:33 EDT 2024 Fri Oct 25 11:19:14 EDT 2024 Thu Nov 21 20:46:30 EST 2024 Sat Nov 02 12:24:49 EDT 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	10
Language	English
License	This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c513t-ca07e8b67693c37a6041ec547ac715c11b9272eb23792b5f6da3c05b34ef35483
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 FG02-02ER15309 USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division These authors contributed equally to this work. Present address: Laboratorio de Bioquímica, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado De México, Mexico 54090.
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787263/
PMID	23739894
PQID	1443381861
PQPubID	23479
PageCount	12
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_3787263 osti_scitechconnect_1625624 proquest_miscellaneous_1458529608 proquest_miscellaneous_1443381861 crossref_primary_10_1101_gr_152538_112 pubmed_primary_23739894
PublicationCentury	2000
PublicationDate	2013-10-01
PublicationDateYYYYMMDD	2013-10-01
PublicationDate_xml	– month: 10 year: 2013 text: 2013-10-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Genome research
PublicationTitleAlternate	Genome Res
PublicationYear	2013
Publisher	Cold Spring Harbor Laboratory Press
Publisher_xml	– name: Cold Spring Harbor Laboratory Press
References	2021111811111570000_23.10.1663.19 2021111811111570000_23.10.1663.18 2021111811111570000_23.10.1663.17 2021111811111570000_23.10.1663.63 2021111811111570000_23.10.1663.62 2021111811111570000_23.10.1663.61 2021111811111570000_23.10.1663.60 2021111811111570000_23.10.1663.27 2021111811111570000_23.10.1663.26 (2021111811111570000_23.10.1663.56) 2012; 73 2021111811111570000_23.10.1663.25 (2021111811111570000_23.10.1663.50) 1993; 135 2021111811111570000_23.10.1663.69 2021111811111570000_23.10.1663.24 2021111811111570000_23.10.1663.68 2021111811111570000_23.10.1663.23 2021111811111570000_23.10.1663.67 2021111811111570000_23.10.1663.22 2021111811111570000_23.10.1663.66 2021111811111570000_23.10.1663.21 2021111811111570000_23.10.1663.65 2021111811111570000_23.10.1663.20 2021111811111570000_23.10.1663.29 2021111811111570000_23.10.1663.28 (2021111811111570000_23.10.1663.40) 2010; 63 2021111811111570000_23.10.1663.3 2021111811111570000_23.10.1663.30 2021111811111570000_23.10.1663.74 2021111811111570000_23.10.1663.2 2021111811111570000_23.10.1663.73 2021111811111570000_23.10.1663.5 2021111811111570000_23.10.1663.72 2021111811111570000_23.10.1663.4 2021111811111570000_23.10.1663.71 2021111811111570000_23.10.1663.7 2021111811111570000_23.10.1663.70 2021111811111570000_23.10.1663.6 2021111811111570000_23.10.1663.9 2021111811111570000_23.10.1663.8 2021111811111570000_23.10.1663.38 (2021111811111570000_23.10.1663.64) 2000; 155 2021111811111570000_23.10.1663.37 2021111811111570000_23.10.1663.36 2021111811111570000_23.10.1663.35 2021111811111570000_23.10.1663.79 2021111811111570000_23.10.1663.34 2021111811111570000_23.10.1663.78 2021111811111570000_23.10.1663.33 2021111811111570000_23.10.1663.77 2021111811111570000_23.10.1663.1 2021111811111570000_23.10.1663.32 2021111811111570000_23.10.1663.76 (2021111811111570000_23.10.1663.16) 2003; 28 2021111811111570000_23.10.1663.31 2021111811111570000_23.10.1663.75 2021111811111570000_23.10.1663.39 2021111811111570000_23.10.1663.41 2021111811111570000_23.10.1663.83 2021111811111570000_23.10.1663.82 2021111811111570000_23.10.1663.81 2021111811111570000_23.10.1663.80 2021111811111570000_23.10.1663.49 2021111811111570000_23.10.1663.48 2021111811111570000_23.10.1663.47 2021111811111570000_23.10.1663.46 2021111811111570000_23.10.1663.45 2021111811111570000_23.10.1663.44 2021111811111570000_23.10.1663.43 2021111811111570000_23.10.1663.42 2021111811111570000_23.10.1663.52 2021111811111570000_23.10.1663.51 2021111811111570000_23.10.1663.15 2021111811111570000_23.10.1663.59 2021111811111570000_23.10.1663.14 2021111811111570000_23.10.1663.58 2021111811111570000_23.10.1663.13 2021111811111570000_23.10.1663.57 2021111811111570000_23.10.1663.12 2021111811111570000_23.10.1663.11 2021111811111570000_23.10.1663.55 2021111811111570000_23.10.1663.10 2021111811111570000_23.10.1663.54 2021111811111570000_23.10.1663.53
References_xml	– ident: 2021111811111570000_23.10.1663.14 doi: 10.3198/jpr2009.09.0546crg – ident: 2021111811111570000_23.10.1663.35 doi: 10.1038/ng.715 – ident: 2021111811111570000_23.10.1663.8 doi: 10.1016/j.cell.2012.09.001 – ident: 2021111811111570000_23.10.1663.32 doi: 10.1371/journal.pgen.1000530 – ident: 2021111811111570000_23.10.1663.38 doi: 10.1093/bioinformatics/btp324 – ident: 2021111811111570000_23.10.1663.65 doi: 10.1105/tpc.111.094870 – ident: 2021111811111570000_23.10.1663.71 doi: 10.1126/science.1165313 – ident: 2021111811111570000_23.10.1663.42 doi: 10.1038/nature09798 – ident: 2021111811111570000_23.10.1663.45 doi: 10.1016/j.pbi.2012.09.001 – ident: 2021111811111570000_23.10.1663.61 doi: 10.1038/nature11968 – ident: 2021111811111570000_23.10.1663.82 doi: 10.1126/science.1186366 – ident: 2021111811111570000_23.10.1663.39 doi: 10.1073/pnas.1016884108 – ident: 2021111811111570000_23.10.1663.30 doi: 10.1126/science.1224839 – ident: 2021111811111570000_23.10.1663.36 doi: 10.1186/gb-2009-10-3-r25 – ident: 2021111811111570000_23.10.1663.67 doi: 10.1016/j.cell.2008.12.038 – ident: 2021111811111570000_23.10.1663.26 doi: 10.1093/bioinformatics/bth397 – ident: 2021111811111570000_23.10.1663.51 – ident: 2021111811111570000_23.10.1663.4 doi: 10.1038/nature10555 – ident: 2021111811111570000_23.10.1663.63 doi: 10.1016/j.tig.2012.10.012 – ident: 2021111811111570000_23.10.1663.13 doi: 10.1038/43657 – ident: 2021111811111570000_23.10.1663.2 doi: 10.1016/j.gde.2010.01.008 – ident: 2021111811111570000_23.10.1663.12 doi: 10.1038/nature06745 – ident: 2021111811111570000_23.10.1663.49 doi: 10.1126/science.1180677 – ident: 2021111811111570000_23.10.1663.58 doi: 10.1016/j.tplants.2012.01.001 – ident: 2021111811111570000_23.10.1663.69 doi: 10.1016/j.ympev.2005.11.018 – ident: 2021111811111570000_23.10.1663.25 doi: 10.1073/pnas.1019217108 – ident: 2021111811111570000_23.10.1663.29 doi: 10.1038/nature11532 – volume: 155 start-page: 369 year: 2000 ident: 2021111811111570000_23.10.1663.64 article-title: Spontaneous mutational effects on reproductive traits of Arabidopsis thaliana publication-title: Genetics doi: 10.1093/genetics/155.1.369 – ident: 2021111811111570000_23.10.1663.7 doi: 10.1007/s00122-005-1970-3 – ident: 2021111811111570000_23.10.1663.1 doi: 10.1038/35048692 – ident: 2021111811111570000_23.10.1663.28 doi: 10.1056/NEJMoa064522 – ident: 2021111811111570000_23.10.1663.59 doi: 10.1016/j.pbi.2011.03.010 – volume: 28 start-page: 567 year: 2003 ident: 2021111811111570000_23.10.1663.16 article-title: Chloroplast-expressed glutamine synthetase in Glycine and related Leguminosae: Phylogeny, gene duplication, and ancient polyploidy publication-title: Syst Bot – volume: 135 start-page: 881 year: 1993 ident: 2021111811111570000_23.10.1663.50 article-title: Paramutation, an allelic interaction, is associated with a stable and heritable reduction of transcription of the maize b regulatory gene publication-title: Genetics doi: 10.1093/genetics/135.3.881 – ident: 2021111811111570000_23.10.1663.24 doi: 10.1073/pnas.1201043109 – ident: 2021111811111570000_23.10.1663.81 doi: 10.1073/pnas.1009695107 – ident: 2021111811111570000_23.10.1663.66 doi: 10.1371/journal.pgen.1003437 – ident: 2021111811111570000_23.10.1663.79 doi: 10.1093/molbev/msm088 – ident: 2021111811111570000_23.10.1663.22 doi: 10.1093/molbev/msm158 – ident: 2021111811111570000_23.10.1663.68 doi: 10.1600/036364409787602221 – ident: 2021111811111570000_23.10.1663.27 doi: 10.1105/tpc.109.072041 – ident: 2021111811111570000_23.10.1663.75 doi: 10.1371/journal.pbio.0050174 – ident: 2021111811111570000_23.10.1663.20 doi: 10.1073/pnas.1002720107 – ident: 2021111811111570000_23.10.1663.57 doi: 10.1534/genetics.111.128744 – ident: 2021111811111570000_23.10.1663.11 doi: 10.4161/fly.19695 – ident: 2021111811111570000_23.10.1663.76 doi: 10.1186/gb-2012-13-10-249 – ident: 2021111811111570000_23.10.1663.52 doi: 10.1371/journal.pgen.0020036 – ident: 2021111811111570000_23.10.1663.6 doi: 10.1093/bioinformatics/btg112 – ident: 2021111811111570000_23.10.1663.44 doi: 10.1038/ng1841 – ident: 2021111811111570000_23.10.1663.74 doi: 10.1105/tpc.109.069856 – ident: 2021111811111570000_23.10.1663.10 doi: 10.1038/ng.911 – ident: 2021111811111570000_23.10.1663.23 doi: 10.1104/pp.109.137935 – ident: 2021111811111570000_23.10.1663.37 doi: 10.1038/nrg2719 – ident: 2021111811111570000_23.10.1663.15 doi: 10.1073/pnas.1209329109 – ident: 2021111811111570000_23.10.1663.60 doi: 10.1126/science.1212959 – ident: 2021111811111570000_23.10.1663.53 doi: 10.1101/gad.524609 – ident: 2021111811111570000_23.10.1663.72 doi: 10.1093/bioinformatics/btp120 – ident: 2021111811111570000_23.10.1663.33 doi: 10.1021/cb300229q – volume: 63 start-page: 86 year: 2010 ident: 2021111811111570000_23.10.1663.40 article-title: An integrated transcriptome atlas of the crop model Glycine max, and its use in comparative analyses in plants publication-title: Plant J – ident: 2021111811111570000_23.10.1663.83 doi: 10.1371/journal.pgen.1000032 – ident: 2021111811111570000_23.10.1663.47 doi: 10.1111/j.1365-313X.2007.03244.x – ident: 2021111811111570000_23.10.1663.70 doi: 10.1073/pnas.1215380110 – ident: 2021111811111570000_23.10.1663.31 doi: 10.1104/pp.108.127902 – ident: 2021111811111570000_23.10.1663.46 doi: 10.1016/j.cell.2007.07.007 – ident: 2021111811111570000_23.10.1663.3 doi: 10.1111/j.1541-0420.2012.01825.x – ident: 2021111811111570000_23.10.1663.17 doi: 10.1016/j.cell.2012.07.034 – ident: 2021111811111570000_23.10.1663.18 doi: 10.1016/j.cub.2011.12.054 – ident: 2021111811111570000_23.10.1663.62 doi: 10.1038/nature08670 – ident: 2021111811111570000_23.10.1663.19 doi: 10.1371/journal.pgen.1002372 – ident: 2021111811111570000_23.10.1663.21 doi: 10.1038/nature10414 – ident: 2021111811111570000_23.10.1663.54 doi: 10.1038/nrg1834 – ident: 2021111811111570000_23.10.1663.9 doi: 10.1016/j.cub.2003.11.052 – ident: 2021111811111570000_23.10.1663.41 doi: 10.1016/j.cell.2008.03.029 – ident: 2021111811111570000_23.10.1663.78 doi: 10.1101/gad.1512007 – ident: 2021111811111570000_23.10.1663.34 doi: 10.2135/cropsci2010.08.0459 – ident: 2021111811111570000_23.10.1663.77 doi: 10.4161/epi.4.2.8214 – ident: 2021111811111570000_23.10.1663.5 doi: 10.1016/0092-8674(95)90185-X – ident: 2021111811111570000_23.10.1663.73 doi: 10.1038/nbt.1621 – ident: 2021111811111570000_23.10.1663.80 doi: 10.1073/pnas.1211757110 – ident: 2021111811111570000_23.10.1663.55 doi: 10.1126/science.273.5275.654 – ident: 2021111811111570000_23.10.1663.43 doi: 10.1105/tpc.112.106427 – ident: 2021111811111570000_23.10.1663.48 doi: 10.1101/gr.080200.108 – volume: 73 start-page: 143 year: 2012 ident: 2021111811111570000_23.10.1663.56 article-title: The fate of duplicated genes in a polyploid plant genome publication-title: Plant J
SSID	ssj0003488
Score	2.5665808
Snippet	Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines...
SourceID	pubmedcentral osti proquest crossref pubmed
SourceType	Open Access Repository Aggregation Database Index Database
StartPage	1663
SubjectTerms	Arabidopsis - genetics Arabidopsis - metabolism BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Bisulfite Cell Division Chromosome Mapping Cytosine - metabolism DNA Methylation DNA Transposable Elements DNA, Plant - genetics DNA, Plant - metabolism DNA, Recombinant Epigenesis, Genetic Epigenomics Gene Expression Regulation, Plant Genes, Plant Genetic Variation Genetics & Heredity Genome, Plant Genotype Glycine max - genetics Glycine max - metabolism Inbreeding Polymorphism, Single Nucleotide Quantitative Trait Loci Sequence Analysis
Title	Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population
URI	https://www.ncbi.nlm.nih.gov/pubmed/23739894 https://search.proquest.com/docview/1443381861 https://search.proquest.com/docview/1458529608 https://www.osti.gov/servlets/purl/1625624 https://pubmed.ncbi.nlm.nih.gov/PMC3787263
Volume	23
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9tAEB1iQ0gvIZ-N47ZsIOQmW6vVaqWj49rkkhBoAz1VSKtVYogk48gt_veZWVmmDiGH3vSxgmVnJM2T3rwHcBnmxuRGp04u8sjxU5k7YRRIBxPaCC2DXNku15sf6u5X-H1CMjmy7YWxpH2dzgblczEoZ0-WWzkv9LDliQ3vb8cCs8wLxLADHawNW4i-fvwKP2z63zAFSHxqI6zJh48La_cjQmqcIRlgoQQJkG-9k7oV3lvv1ZtvaZP_vIemB7C_LiDZqJnoIeyY8giORyWC52LFrpildNpv5Uewe91u7Y1bY7dj-D2ZW2nWwjh_Z5lhs5J6AGsKP6typld1RWR4RubSq4Yqx_4gpCbGDA5mCSMUXaSWQ4MHEFRnbL4xAjuBh-nk5_jGWdssOFpyUTs6cZUJU-uKqIVKAtfnRktfJVpxqTlPI095iMCFijwMZpAlQrsyFb7JBQIecQrdsirNGTAMMw9kFklpEl9HPHGlxpIlIyYI2Yv24Kpd6HjeqGnEFoW4PH5cxE1wcNfrQZ_CEGMZQFq2mkg_uo45orXA83tw0UYnxrWjXxxJaarlCwIZX1ANEvCPxiBE8hC54XQ-NxHdTKbNiB6orVhvBpAa9_YZTFKryr1OyvP_vrIPnzzy2rBMwS_QrRdL8xU6L9nym83wV6GIAE4
link.rule.ids	230,315,729,782,786,887,27933,27934,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db5swFL1aM03dS9ul65r1Y5409Y0GY4zhsc1SpVobTVom7WkIjOkiDYhSsin_fveaEDXTtIe8ATYS4GN8D5x7LsCHMDcmNzp1cpFHjp_K3AmjQDoIaCO0DHJls1xHX9T4W_hxSDY5ss2FsaJ9nU4vy5_FZTn9YbWVs0L3W51Y__P9QCDKvED0d-A5zlfXbUn66gUs_LDJgEMQkP3U2lqT9x_mtuCPCCl1hoyAhRJkQb6xKnUqnF3_ijj_Fk4-WYlu9re8hwPYW4We7KppfgXPTNmFw6sSaXexZBfMikHtV_YuvLhut3YHbUm4Q_g-nFlT18I4v6eZYdOSsgdrAg6rcqaXdUUyekZlqZeNyI79QjJOWhvszBJG_LtIrfoGDyAdz9hsXULsNXy9GU4GI2dVoMHRkova0YmrTJjaeopaqCRwfW609FWiFZea8zTylIfcXajIQxgEWSK0K1Phm1wgVRJH0Cmr0hwDQ4DwQGaRlCbxdcQTV2oMdjLSkFBh0h5ctAMUzxofjtjyF5fHD_O4GVTc9XpwQsMXYwBBLria5EK6jjnyvMDze_C-HdUYnx39HElKUy0ekQL5gqKXgP-vD5IrDzkfXs6bBgnri2mR1AO1gZF1B_Lx3mxBaFg_7xUU3m595jvYHU3u7-K72_GnE3jpUcUOqzc8hU49X5gz2HnMFud2lvwBQKoV2g
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bj5QwGP3ijvHy4mXXy7heamL2jYW2lMLjOjuTNepmEzXxSQKlrJPIJbOMZv6931cG4hjjg75xKQnQU_gOnJ4D8CourS2tyb1SlokX5qr04iRSHgLaSqOiUrtZrmcf9Pnn-HRONjlj1JcT7Zt8eVx_q47r5VenrWwr4w86Mf_i_UwiykQk_bYo_T24jmM2EANR3z6EZRj3s-AQCGRBNdprcv9y5UJ_ZEzTZ8gMWGpJNuQ7b6ZJgyPsT1Xn7-LJX95Gi7v_cR334M62BGUnfZP7cM3W-3BwUiP9rjbsiDlRqPvavg83Xg9Lt2ZDNNwBfJm3zty1st6PZWHZsqZZhB0BiDUlM5uuITk9o3jqTS-2Y9-RlJPmBhuzjBEPr3KnwsENSMsL1o5RYg_g02L-cXbmbYMaPKO47DyTBdrGuctVNFJnURBya1SoM6O5MpznidACObzUiUA4REUmTaByGdpSImWSD2FSN7V9DAyBwiNVJErZLDQJzwJlsOgpSEtCAaVTOBo6KW17P47U8ZiAp5ertO9YXBVTOKQuTLGQIDdcQ7Ih06Uc-V4kwim8HHo2xXtHP0my2jbrK6RCoaQqJuJ_a4MkSyD3w9N51KNhPJkBTVPQOzgZG5Cf9-4ehIfz9d7C4ck_H_kCbl6cLtJ3b87fHsJtQcEdTnb4FCbdam2fwd5VsX7uBspPAC8YWg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epigenome-wide+inheritance+of+cytosine+methylation+variants+in+a+recombinant+inbred+population&rft.jtitle=Genome+research&rft.au=Schmitz%2C+R+J&rft.au=He%2C+Y&rft.au=Valdes-Lopez%2C+O&rft.au=Khan%2C+S+M&rft.date=2013-10-01&rft.issn=1088-9051&rft.volume=23&rft.issue=10&rft.spage=1663&rft.epage=1674&rft_id=info:doi/10.1101%2Fgr.152538.112&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1088-9051&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1088-9051&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1088-9051&client=summon