Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils

• Published in: Immunology letters Vol. 160; no. 1; pp. 72 - 78
• Main Authors: Tamaki, Mami, Konno, Yasunori, Kobayashi, Yoshiki, Takeda, Masahide, Itoga, Masamichi, Moritoki, Yuki, Oyamada, Hajime, Kayaba, Hiroyuki, Chihara, Junichi, Ueki, Shigeharu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-07-2014
• Subjects: Allergy and Immunology; Apoptosis - drug effects; Asthma; Cell Degranulation - drug effects; Cell Degranulation - immunology; Chemokine CCL11 - pharmacology; Chemotaxis; Chemotaxis, Leukocyte - drug effects; Chemotaxis, Leukocyte - immunology; Eosinophils; Eosinophils - drug effects; Eosinophils - immunology; Eosinophils - metabolism; Gene Expression Regulation - drug effects; GPER; GPR30; Humans; Hypersensitivity - genetics; Hypersensitivity - immunology; Hypersensitivity - metabolism; Male; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Survival; estrogen receptor; G-protein-coupled estrogen receptor; GPER; GPR30; eosinophil derived neurotoxin; ER; Chemotaxis; Survival; EDN; Asthma; Eosinophils
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2014.03.012

Highlights • Sexual dimorphism in asthma links the estrogen and allergic immune responses. • GPER, a membrane receptor for estrogen, is expressed in human eosinophils. • GPER activation regulates chemotaxis and apoptosis of eosinophils. • Our study suggests that GPER might be a novel regulator of allergic inflammation.