Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence
The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of q...
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| Published in: | Cell Vol. 143; no. 7; pp. 1161 - 1173 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
23-12-2010
Elsevier Cell Press |
| Subjects: | |
| Online Access: | Get full text |
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| Abstract | The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control.
[Display omitted]
► Stellate glia express insulin/IGF-like peptides (dILPs) in response to nutrition ► Insulin receptor/PI3K signaling is required for neural stem cell (NSC) reactivation ► Glial dILP expression is sufficient to reactivate NSCs irrespective of nutrition ► Glial signaling is essential for NSC exit from quiescence |
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| AbstractList | The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control. The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control. [Display omitted] ► Stellate glia express insulin/IGF-like peptides (dILPs) in response to nutrition ► Insulin receptor/PI3K signaling is required for neural stem cell (NSC) reactivation ► Glial dILP expression is sufficient to reactivate NSCs irrespective of nutrition ► Glial signaling is essential for NSC exit from quiescence The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control. The systemic regulation of stem cells ensures that they meet the needs of the organism during growth and in response to injury. A key point of regulation is the decision between quiescence and proliferation. During development, Drosophila neural stem cells (neuroblasts) transit through a period of quiescence separating distinct embryonic and postembryonic phases of proliferation. It is known that neuroblasts exit quiescence via a hitherto unknown pathway in response to a nutrition-dependent signal from the fat body. We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for neuroblasts to exit quiescence. The forced expression of insulin/IGF-like peptides in glia, or activation of PI3K/Akt signaling in neuroblasts, can drive neuroblast growth and proliferation in the absence of dietary protein and thus uncouple neuroblasts from systemic control. |
| Author | Brand, Andrea H. Chell, James M. |
| AuthorAffiliation | 1 The Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK |
| AuthorAffiliation_xml | – name: 1 The Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK |
| Author_xml | – sequence: 1 givenname: James M. surname: Chell fullname: Chell, James M. organization: The Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK – sequence: 2 givenname: Andrea H. surname: Brand fullname: Brand, Andrea H. email: ahb@mole.bio.cam.ac.uk organization: The Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21183078$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/1623640$$D View this record in Osti.gov |
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| Cites_doi | 10.1128/MCB.8.4.1638 10.1016/S0092-8674(01)00465-2 10.1242/dev.010876 10.1073/pnas.0509939103 10.1007/s12015-006-0051-6 10.1016/0012-1606(88)90067-X 10.1046/j.1432-0436.2003.7107001.x 10.1128/MCB.23.24.9117-9126.2003 10.1126/science.1068094 10.1093/nar/gkh014 10.1002/gene.10127 10.1016/j.devcel.2009.10.009 10.1101/gad.13.24.3244 10.1002/glia.20187 10.1016/S0960-9822(02)01043-6 10.1101/gad.13.1.98 10.1002/j.1460-2075.1995.tb07343.x 10.1371/journal.pgen.1000990 10.1042/bj20030577 10.1016/j.cell.2008.02.007 10.1016/j.cmet.2009.08.002 10.1016/S1534-5807(02)00117-X 10.1073/pnas.96.20.11619 10.1126/science.1070058 10.1016/0006-8993(92)91695-B 10.1242/jcs.019661 10.1007/BF00399871 10.1016/S0012-1606(02)00019-2 10.1101/gad.6.11.2137 10.1006/dbio.2001.0411 10.1016/S0960-9822(99)80450-3 10.1016/S0896-6273(00)80701-1 10.1002/neu.1018 10.1371/journal.pgen.1000857 10.1074/jbc.273.22.13375 10.1128/MCB.17.11.6727 10.1016/j.conb.2005.08.003 10.1016/j.cell.2008.01.033 10.1523/JNEUROSCI.1700-08.2009 10.1038/70293 10.1002/j.1460-2075.1996.tb01049.x 10.1046/j.1432-1327.2000.01337.x 10.1186/1471-213X-7-121 10.1371/journal.pone.0003721 10.1016/S0925-4773(98)00068-9 10.1002/jnr.20288 10.1126/science.1089035 10.1016/0896-6273(94)90046-9 10.1242/jcs.02532 10.1073/pnas.101596998 10.1242/dev.111.1.79 10.1016/j.cell.2008.03.034 10.1016/j.cub.2005.04.054 10.1016/j.ydbio.2008.02.025 10.1038/417039a 10.1038/cr.2009.56 10.1002/dvdy.10120 10.1038/nature03994 10.1111/j.1460-9568.2006.04872.x 10.1073/pnas.011318098 10.1523/JNEUROSCI.23-08-03325.2003 10.1242/dev.126.23.5365 10.1101/sqb.2008.73.018 10.1242/dev.129.17.4103 10.1242/dev.025189 10.1002/bit.20246 10.1016/S0960-9822(01)00068-9 10.1523/JNEUROSCI.4367-07.2008 10.1534/genetics.106.065961 10.1016/S0165-3806(02)00277-8 10.1016/0092-8674(93)90291-W 10.1098/rstb.2006.2011 10.1242/dev.121.4.1173 10.1126/science.1111410 10.1016/S1044-7431(03)00082-4 10.1242/dev.125.11.2149 10.1371/journal.pbio.0040083 10.1210/en.2008-0920 10.1016/j.cell.2008.01.038 10.1016/j.devcel.2009.10.008 10.1126/science.1110542 10.1016/0012-1606(92)90270-Q 10.1534/genetics.108.098244 10.1016/S0092-8674(03)00713-X |
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| ISSN | 0092-8674 |
| IngestDate | Tue Sep 17 21:27:56 EDT 2024 Thu May 18 22:32:35 EDT 2023 Sat Oct 26 01:29:15 EDT 2024 Fri Oct 25 00:12:34 EDT 2024 Thu Nov 21 22:06:00 EST 2024 Sat Sep 28 08:35:35 EDT 2024 Fri Feb 23 02:28:03 EST 2024 |
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| Issue | 7 |
| Language | English |
| License | http://creativecommons.org/licenses/by/3.0 Copyright © 2010 Elsevier Inc. All rights reserved. Open Access under CC BY 3.0 license |
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| References | LaFever, Drummond-Barbosa (bib39) 2005; 309 Alam, Sen, Behie, Kallos (bib3) 2004; 88 Lizcano, Alrubaie, Kieloch, Deak, Leevers, Alessi (bib42) 2003; 374 Mairet-Coello, Tury, DiCicco-Bloom (bib46) 2009; 29 Rintelen, Stocker, Thomas, Hafen (bib59) 2001; 98 Ye, Popken, Kemper, McCarthy, Popko, D'Ercole (bib76) 2004; 78 Park, Rangel, Reynolds, Caldwell, Johns, Nayak, Welsh, McDermott, Datta (bib56) 2003; 253 Weinkove, Neufeld, Twardzik, Waterfield, Leevers (bib73) 1999; 9 Brogiolo, Stocker, Ikeya, Rintelen, Fernandez, Hafen (bib10) 2001; 11 Zhu, Boone, Jensen, Hanna, Podemski, Locke, Doe, O'Connor (bib79) 2008; 135 Morrison, Spradling (bib51) 2008; 132 Rulifson, Kim, Nusse (bib60) 2002; 296 Ikeya, Galic, Belawat, Nairz, Hafen (bib33) 2002; 12 McGuire, Le, Osborn, Matsumoto, Davis (bib48) 2003; 302 Ahn, Joyner (bib2) 2005; 437 Egger, Chell, Brand (bib21) 2008; 363 Verdu, Buratovich, Wilder, Birnbaum (bib71) 1999; 1 Zhao, Deng, Gage (bib78) 2008; 132 Ma, Ming, Song (bib43) 2005; 15 Cho, Lee, Kim, Kim, Koh, Lee, Kim, Kim, Chung (bib13) 2001; 98 Coller, Sang, Roberts (bib14) 2006; 4 Oldham, Stocker, Laffargue, Wittwer, Wymann, Hafen (bib55) 2002; 129 Anderson, Aberg, Nilsson, Eriksson (bib4) 2002; 134 Woodward, Chen, Behbod, Rosen (bib74) 2005; 118 Knoblich (bib37) 2008; 132 Britton, Edgar (bib8) 1998; 125 Song, Stevens, Gage (bib65) 2002; 417 Géminard, Rulifson, Léopold (bib26) 2009; 10 Miron, Lasko, Sonenberg (bib49) 2003; 23 Stork, Engelen, Krudewig, Silies, Bainton, Klämbt (bib67) 2008; 28 Grönke, Clarke, Broughton, Andrews, Partridge (bib29) 2010; 6 Datta (bib16) 1995; 121 Friedrich, Schneider, Timpl, Baumgartner (bib23) 2000; 267 Garcia-Estrada, Garcia-Segura, Torres-Aleman (bib24) 1992; 592 Prokop, Bray, Harrison, Technau (bib57) 1998; 74 Androutsellis-Theotokis, Rueger, Mkhikian, Korb, McKay (bib5) 2008; 73 Maehama, Dixon (bib45) 1998; 273 Sepp, Schulte, Auld (bib61) 2001; 238 Doetsch, García-Verdugo, Alvarez-Buylla (bib17) 1999; 96 Broughton, Alic, Slack, Bass, Ikeya, Vinti, Tommasi, Driege, Hafen, Partridge (bib11) 2008; 3 Drummond-Barbosa (bib18) 2008; 180 Aberg, Aberg, Palmer, Alborn, Carlsson-Skwirut, Bang, Rosengren, Olsson, Gage, Eriksson (bib1) 2003; 24 Barrett, Krueger, Datta (bib6) 2008; 317 Shetty, Hattiangady, Shetty (bib63) 2005; 51 Tsuji, Hasegawa, Isshiki (bib69) 2008; 135 Kockel, Kerr, Melnick, Brückner, Hebrok, Perrimon (bib38) 2010; 6 Uv, Harrison, Bray (bib70) 1997; 17 Groszer, Erickson, Scripture-Adams, Dougherty, Le Belle, Zack, Geschwind, Liu, Kornblum, Wu (bib30) 2006; 103 Yan, Sailor, Vemuganti, Dempsey (bib75) 2006; 24 Moore, Lemischka (bib50) 2006; 311 Ma, Bonaguidi, Ming, Song (bib44) 2009; 19 Slaidina, Delanoue, Gronke, Partridge, Léopold (bib64) 2009; 17 Morshead, Reynolds, Craig, McBurney, Staines, Morassutti, Weiss, van der Kooy (bib52) 1994; 13 Lindner, Hillman, Barrett, Jackson, Perry, Park, Datta (bib41) 2007; 7 Nern, Momma (bib53) 2006; 2 Prokop, Technau (bib58) 1991; 111 Okamoto, Yamanaka, Yagi, Nishida, Kataoka, O'Connor, Mizoguchi (bib54) 2009; 17 Garofalo, Rosen (bib25) 1988; 8 Britton, Lockwood, Li, Cohen, Edgar (bib9) 2002; 2 Isshiki, Pearson, Holbrook, Doe (bib34) 2001; 106 Truman, Bate (bib68) 1988; 125 Leevers, Weinkove, MacDougall, Hafen, Waterfield (bib40) 1996; 15 Dumstrei, Wang, Hartenstein (bib19) 2003; 23 Ito, Hotta (bib35) 1992; 149 Ebens, Garren, Cheyette, Zipursky (bib20) 1993; 74 Bier, Vaessin, Younger-Shepherd, Jan, Jan (bib7) 1992; 6 Goberdhan, Wilson (bib27) 2003; 71 Hartenstein, Rudloff, Campos-Ortega (bib31) 1987; 196 Colombani, Raisin, Pantalacci, Radimerski, Montagne, Léopold (bib15) 2003; 114 Stocker, Andjelkovic, Oldham, Laffargue, Wymann, Hemmings, Hafen (bib66) 2002; 295 Zammit (bib77) 2008; 121 Goberdhan, Paricio, Goodman, Mlodzik, Wilson (bib28) 1999; 13 Fernandez, Tabarini, Azpiazu, Frasch, Schlessinger (bib22) 1995; 14 Joseph D'Ercole, Ye (bib36) 2008; 149 Maurange, Cheng, Gould (bib47) 2008; 133 Huang, Potter, Tao, Li, Brogiolo, Hafen, Sun, Xu (bib32) 1999; 126 Sharma, Cheung, Larsen, Eberl (bib62) 2002; 34 Voigt, Pflanz, Schäfer, Jäckle (bib72) 2002; 224 Brummel, Abdollah, Haerry, Shimell, Merriam, Raftery, Wrana, O'Connor (bib12) 1999; 13 21474096 - Cell Stem Cell. 2011 Apr 8;8(4):352-4 21309091 - Nat Rev Neurosci. 2011 Feb;12(2):62 Fernandez (10.1016/j.cell.2010.12.007_bib22) 1995; 14 Sharma (10.1016/j.cell.2010.12.007_bib62) 2002; 34 Cho (10.1016/j.cell.2010.12.007_bib13) 2001; 98 Zhao (10.1016/j.cell.2010.12.007_bib78) 2008; 132 Colombani (10.1016/j.cell.2010.12.007_bib15) 2003; 114 Géminard (10.1016/j.cell.2010.12.007_bib26) 2009; 10 Zhu (10.1016/j.cell.2010.12.007_bib79) 2008; 135 Park (10.1016/j.cell.2010.12.007_bib56) 2003; 253 Tsuji (10.1016/j.cell.2010.12.007_bib69) 2008; 135 Stocker (10.1016/j.cell.2010.12.007_bib66) 2002; 295 Prokop (10.1016/j.cell.2010.12.007_bib58) 1991; 111 Rintelen (10.1016/j.cell.2010.12.007_bib59) 2001; 98 10.1016/j.cell.2010.12.007_bib93 Joseph D'Ercole (10.1016/j.cell.2010.12.007_bib36) 2008; 149 10.1016/j.cell.2010.12.007_bib92 10.1016/j.cell.2010.12.007_bib91 10.1016/j.cell.2010.12.007_bib90 Morrison (10.1016/j.cell.2010.12.007_bib51) 2008; 132 Nern (10.1016/j.cell.2010.12.007_bib53) 2006; 2 Ma (10.1016/j.cell.2010.12.007_bib44) 2009; 19 Ye (10.1016/j.cell.2010.12.007_bib76) 2004; 78 Ito (10.1016/j.cell.2010.12.007_bib35) 1992; 149 Brogiolo (10.1016/j.cell.2010.12.007_bib10) 2001; 11 Hartenstein (10.1016/j.cell.2010.12.007_bib31) 1987; 196 Zammit (10.1016/j.cell.2010.12.007_bib77) 2008; 121 Egger (10.1016/j.cell.2010.12.007_bib21) 2008; 363 Leevers (10.1016/j.cell.2010.12.007_bib40) 1996; 15 Moore (10.1016/j.cell.2010.12.007_bib50) 2006; 311 Prokop (10.1016/j.cell.2010.12.007_bib57) 1998; 74 Ikeya (10.1016/j.cell.2010.12.007_bib33) 2002; 12 Dumstrei (10.1016/j.cell.2010.12.007_bib19) 2003; 23 Doetsch (10.1016/j.cell.2010.12.007_bib17) 1999; 96 Goberdhan (10.1016/j.cell.2010.12.007_bib28) 1999; 13 Oldham (10.1016/j.cell.2010.12.007_bib55) 2002; 129 Barrett (10.1016/j.cell.2010.12.007_bib6) 2008; 317 Drummond-Barbosa (10.1016/j.cell.2010.12.007_bib18) 2008; 180 Kockel (10.1016/j.cell.2010.12.007_bib38) 2010; 6 Lizcano (10.1016/j.cell.2010.12.007_bib42) 2003; 374 Brummel (10.1016/j.cell.2010.12.007_bib12) 1999; 13 Maehama (10.1016/j.cell.2010.12.007_bib45) 1998; 273 Song (10.1016/j.cell.2010.12.007_bib65) 2002; 417 Bier (10.1016/j.cell.2010.12.007_bib7) 1992; 6 Shetty (10.1016/j.cell.2010.12.007_bib63) 2005; 51 Voigt (10.1016/j.cell.2010.12.007_bib72) 2002; 224 Grönke (10.1016/j.cell.2010.12.007_bib29) 2010; 6 Mairet-Coello (10.1016/j.cell.2010.12.007_bib46) 2009; 29 Stork (10.1016/j.cell.2010.12.007_bib67) 2008; 28 Lindner (10.1016/j.cell.2010.12.007_bib41) 2007; 7 Alam (10.1016/j.cell.2010.12.007_bib3) 2004; 88 Groszer (10.1016/j.cell.2010.12.007_bib30) 2006; 103 Morshead (10.1016/j.cell.2010.12.007_bib52) 1994; 13 Truman (10.1016/j.cell.2010.12.007_bib68) 1988; 125 Okamoto (10.1016/j.cell.2010.12.007_bib54) 2009; 17 Slaidina (10.1016/j.cell.2010.12.007_bib64) 2009; 17 Coller (10.1016/j.cell.2010.12.007_bib14) 2006; 4 Yan (10.1016/j.cell.2010.12.007_bib75) 2006; 24 McGuire (10.1016/j.cell.2010.12.007_bib48) 2003; 302 Woodward (10.1016/j.cell.2010.12.007_bib74) 2005; 118 Datta (10.1016/j.cell.2010.12.007_bib16) 1995; 121 Miron (10.1016/j.cell.2010.12.007_bib49) 2003; 23 Androutsellis-Theotokis (10.1016/j.cell.2010.12.007_bib5) 2008; 73 Uv (10.1016/j.cell.2010.12.007_bib70) 1997; 17 Friedrich (10.1016/j.cell.2010.12.007_bib23) 2000; 267 Britton (10.1016/j.cell.2010.12.007_bib8) 1998; 125 Rulifson (10.1016/j.cell.2010.12.007_bib60) 2002; 296 Verdu (10.1016/j.cell.2010.12.007_bib71) 1999; 1 Ma (10.1016/j.cell.2010.12.007_bib43) 2005; 15 Weinkove (10.1016/j.cell.2010.12.007_bib73) 1999; 9 LaFever (10.1016/j.cell.2010.12.007_bib39) 2005; 309 Anderson (10.1016/j.cell.2010.12.007_bib4) 2002; 134 Huang (10.1016/j.cell.2010.12.007_bib32) 1999; 126 Garofalo (10.1016/j.cell.2010.12.007_bib25) 1988; 8 Ahn (10.1016/j.cell.2010.12.007_bib2) 2005; 437 Britton (10.1016/j.cell.2010.12.007_bib9) 2002; 2 10.1016/j.cell.2010.12.007_bib84 Garcia-Estrada (10.1016/j.cell.2010.12.007_bib24) 1992; 592 10.1016/j.cell.2010.12.007_bib83 10.1016/j.cell.2010.12.007_bib82 10.1016/j.cell.2010.12.007_bib81 Isshiki (10.1016/j.cell.2010.12.007_bib34) 2001; 106 10.1016/j.cell.2010.12.007_bib80 Goberdhan (10.1016/j.cell.2010.12.007_bib27) 2003; 71 Maurange (10.1016/j.cell.2010.12.007_bib47) 2008; 133 Knoblich (10.1016/j.cell.2010.12.007_bib37) 2008; 132 Aberg (10.1016/j.cell.2010.12.007_bib1) 2003; 24 Ebens (10.1016/j.cell.2010.12.007_bib20) 1993; 74 10.1016/j.cell.2010.12.007_bib89 10.1016/j.cell.2010.12.007_bib88 Broughton (10.1016/j.cell.2010.12.007_bib11) 2008; 3 10.1016/j.cell.2010.12.007_bib87 10.1016/j.cell.2010.12.007_bib86 Sepp (10.1016/j.cell.2010.12.007_bib61) 2001; 238 10.1016/j.cell.2010.12.007_bib85 |
| References_xml | – volume: 51 start-page: 173 year: 2005 end-page: 186 ident: bib63 article-title: Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes publication-title: Glia contributor: fullname: Shetty – volume: 1 start-page: 500 year: 1999 end-page: 506 ident: bib71 article-title: Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB publication-title: Nat. Cell Biol. contributor: fullname: Birnbaum – volume: 74 start-page: 99 year: 1998 end-page: 110 ident: bib57 article-title: Homeotic regulation of segment-specific differences in neuroblast numbers and proliferation in the Drosophila central nervous system publication-title: Mech. Dev. contributor: fullname: Technau – volume: 309 start-page: 1071 year: 2005 end-page: 1073 ident: bib39 article-title: Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila publication-title: Science contributor: fullname: Drummond-Barbosa – volume: 4 start-page: e83 year: 2006 ident: bib14 article-title: A new description of cellular quiescence publication-title: PLoS Biol. contributor: fullname: Roberts – volume: 19 start-page: 672 year: 2009 end-page: 682 ident: bib44 article-title: Adult neural stem cells in the mammalian central nervous system publication-title: Cell Res. contributor: fullname: Song – volume: 23 start-page: 9117 year: 2003 end-page: 9126 ident: bib49 article-title: Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster publication-title: Mol. Cell. Biol. contributor: fullname: Sonenberg – volume: 363 start-page: 39 year: 2008 end-page: 56 ident: bib21 article-title: Insights into neural stem cell biology from flies publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. contributor: fullname: Brand – volume: 114 start-page: 739 year: 2003 end-page: 749 ident: bib15 article-title: A nutrient sensor mechanism controls Drosophila growth publication-title: Cell contributor: fullname: Léopold – volume: 2 start-page: 233 year: 2006 end-page: 240 ident: bib53 article-title: The realized niche of adult neural stem cells publication-title: Stem Cell Rev. contributor: fullname: Momma – volume: 6 start-page: 2137 year: 1992 end-page: 2151 ident: bib7 article-title: deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product publication-title: Genes Dev. contributor: fullname: Jan – volume: 149 start-page: 134 year: 1992 end-page: 148 ident: bib35 article-title: Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogaster publication-title: Dev. Biol. contributor: fullname: Hotta – volume: 34 start-page: 115 year: 2002 end-page: 118 ident: bib62 article-title: PPTGAL, a convenient Gal4 P-element vector for testing expression of enhancer fragments in drosophila publication-title: Genesis contributor: fullname: Eberl – volume: 15 start-page: 514 year: 2005 end-page: 520 ident: bib43 article-title: Glial influences on neural stem cell development: cellular niches for adult neurogenesis publication-title: Curr. Opin. Neurobiol. contributor: fullname: Song – volume: 134 start-page: 115 year: 2002 end-page: 122 ident: bib4 article-title: Insulin-like growth factor-I and neurogenesis in the adult mammalian brain publication-title: Brain Res. Dev. Brain Res. contributor: fullname: Eriksson – volume: 133 start-page: 891 year: 2008 end-page: 902 ident: bib47 article-title: Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila publication-title: Cell contributor: fullname: Gould – volume: 17 start-page: 885 year: 2009 end-page: 891 ident: bib54 article-title: A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila publication-title: Dev. Cell contributor: fullname: Mizoguchi – volume: 295 start-page: 2088 year: 2002 end-page: 2091 ident: bib66 article-title: Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB publication-title: Science contributor: fullname: Hafen – volume: 98 start-page: 6144 year: 2001 end-page: 6149 ident: bib13 article-title: Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Chung – volume: 121 start-page: 1173 year: 1995 end-page: 1182 ident: bib16 article-title: Control of proliferation activation in quiescent neuroblasts of the Drosophila central nervous system publication-title: Development contributor: fullname: Datta – volume: 103 start-page: 111 year: 2006 end-page: 116 ident: bib30 article-title: PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Wu – volume: 374 start-page: 297 year: 2003 end-page: 306 ident: bib42 article-title: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B publication-title: Biochem. J. contributor: fullname: Alessi – volume: 317 start-page: 234 year: 2008 end-page: 245 ident: bib6 article-title: Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain publication-title: Dev. Biol. contributor: fullname: Datta – volume: 12 start-page: 1293 year: 2002 end-page: 1300 ident: bib33 article-title: Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila publication-title: Curr. Biol. contributor: fullname: Hafen – volume: 302 start-page: 1765 year: 2003 end-page: 1768 ident: bib48 article-title: Spatiotemporal rescue of memory dysfunction in Drosophila publication-title: Science contributor: fullname: Davis – volume: 111 start-page: 79 year: 1991 end-page: 88 ident: bib58 article-title: The origin of postembryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster publication-title: Development contributor: fullname: Technau – volume: 24 start-page: 45 year: 2006 end-page: 54 ident: bib75 article-title: Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation publication-title: Eur. J. Neurosci. contributor: fullname: Dempsey – volume: 29 start-page: 775 year: 2009 end-page: 788 ident: bib46 article-title: Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex publication-title: J. Neurosci. contributor: fullname: DiCicco-Bloom – volume: 224 start-page: 403 year: 2002 end-page: 412 ident: bib72 article-title: Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts publication-title: Dev. Dyn. contributor: fullname: Jäckle – volume: 437 start-page: 894 year: 2005 end-page: 897 ident: bib2 article-title: In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog publication-title: Nature contributor: fullname: Joyner – volume: 7 start-page: 121 year: 2007 ident: bib41 article-title: The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts publication-title: BMC Dev. Biol. contributor: fullname: Datta – volume: 13 start-page: 3244 year: 1999 end-page: 3258 ident: bib28 article-title: Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway publication-title: Genes Dev. contributor: fullname: Wilson – volume: 118 start-page: 3585 year: 2005 end-page: 3594 ident: bib74 article-title: On mammary stem cells publication-title: J. Cell Sci. contributor: fullname: Rosen – volume: 129 start-page: 4103 year: 2002 end-page: 4109 ident: bib55 article-title: The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels publication-title: Development contributor: fullname: Hafen – volume: 6 start-page: e1000857 year: 2010 ident: bib29 article-title: Molecular evolution and functional characterization of Drosophila insulin-like peptides publication-title: PLoS Genet. contributor: fullname: Partridge – volume: 135 start-page: 513 year: 2008 end-page: 521 ident: bib79 article-title: Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain publication-title: Development contributor: fullname: O'Connor – volume: 17 start-page: 6727 year: 1997 end-page: 6735 ident: bib70 article-title: Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead publication-title: Mol. Cell. Biol. contributor: fullname: Bray – volume: 296 start-page: 1118 year: 2002 end-page: 1120 ident: bib60 article-title: Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes publication-title: Science contributor: fullname: Nusse – volume: 9 start-page: 1019 year: 1999 end-page: 1029 ident: bib73 article-title: Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor publication-title: Curr. Biol. contributor: fullname: Leevers – volume: 592 start-page: 343 year: 1992 end-page: 347 ident: bib24 article-title: Expression of insulin-like growth factor I by astrocytes in response to injury publication-title: Brain Res. contributor: fullname: Torres-Aleman – volume: 267 start-page: 3149 year: 2000 end-page: 3159 ident: bib23 article-title: Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression publication-title: Eur. J. Biochem. contributor: fullname: Baumgartner – volume: 125 start-page: 2149 year: 1998 end-page: 2158 ident: bib8 article-title: Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms publication-title: Development contributor: fullname: Edgar – volume: 28 start-page: 587 year: 2008 end-page: 597 ident: bib67 article-title: Organization and function of the blood-brain barrier in Drosophila publication-title: J. Neurosci. contributor: fullname: Klämbt – volume: 149 start-page: 5958 year: 2008 end-page: 5962 ident: bib36 article-title: Expanding the mind: insulin-like growth factor I and brain development publication-title: Endocrinology contributor: fullname: Ye – volume: 73 start-page: 403 year: 2008 end-page: 410 ident: bib5 article-title: Signaling pathways controlling neural stem cells slow progressive brain disease publication-title: Cold Spring Harb. Symp. Quant. Biol. contributor: fullname: McKay – volume: 71 start-page: 375 year: 2003 end-page: 397 ident: bib27 article-title: The functions of insulin signaling: size isn't everything, even in Drosophila publication-title: Differentiation contributor: fullname: Wilson – volume: 15 start-page: 6584 year: 1996 end-page: 6594 ident: bib40 article-title: The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth publication-title: EMBO J. contributor: fullname: Waterfield – volume: 8 start-page: 1638 year: 1988 end-page: 1647 ident: bib25 article-title: Tissue localization of Drosophila melanogaster insulin receptor transcripts during development publication-title: Mol. Cell. Biol. contributor: fullname: Rosen – volume: 132 start-page: 598 year: 2008 end-page: 611 ident: bib51 article-title: Stem cells and niches: mechanisms that promote stem cell maintenance throughout life publication-title: Cell contributor: fullname: Spradling – volume: 135 start-page: 3859 year: 2008 end-page: 3869 ident: bib69 article-title: Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors publication-title: Development contributor: fullname: Isshiki – volume: 14 start-page: 3373 year: 1995 end-page: 3384 ident: bib22 article-title: The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential publication-title: EMBO J. contributor: fullname: Schlessinger – volume: 98 start-page: 15020 year: 2001 end-page: 15025 ident: bib59 article-title: PDK1 regulates growth through Akt and S6K in Drosophila publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Hafen – volume: 311 start-page: 1880 year: 2006 end-page: 1885 ident: bib50 article-title: Stem cells and their niches publication-title: Science contributor: fullname: Lemischka – volume: 253 start-page: 247 year: 2003 end-page: 257 ident: bib56 article-title: Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division publication-title: Dev. Biol. contributor: fullname: Datta – volume: 126 start-page: 5365 year: 1999 end-page: 5372 ident: bib32 article-title: PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development publication-title: Development contributor: fullname: Xu – volume: 106 start-page: 511 year: 2001 end-page: 521 ident: bib34 article-title: Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny publication-title: Cell contributor: fullname: Doe – volume: 10 start-page: 199 year: 2009 end-page: 207 ident: bib26 article-title: Remote control of insulin secretion by fat cells in Drosophila publication-title: Cell Metab. contributor: fullname: Léopold – volume: 78 start-page: 472 year: 2004 end-page: 484 ident: bib76 article-title: Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression publication-title: J. Neurosci. Res. contributor: fullname: D'Ercole – volume: 417 start-page: 39 year: 2002 end-page: 44 ident: bib65 article-title: Astroglia induce neurogenesis from adult neural stem cells publication-title: Nature contributor: fullname: Gage – volume: 121 start-page: 2975 year: 2008 end-page: 2982 ident: bib77 article-title: All muscle satellite cells are equal, but are some more equal than others? publication-title: J. Cell Sci. contributor: fullname: Zammit – volume: 180 start-page: 1787 year: 2008 end-page: 1797 ident: bib18 article-title: Stem cells, their niches and the systemic environment: an aging network publication-title: Genetics contributor: fullname: Drummond-Barbosa – volume: 17 start-page: 874 year: 2009 end-page: 884 ident: bib64 article-title: A Drosophila insulin-like peptide promotes growth during nonfeeding states publication-title: Dev. Cell contributor: fullname: Léopold – volume: 13 start-page: 1071 year: 1994 end-page: 1082 ident: bib52 article-title: Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells publication-title: Neuron contributor: fullname: van der Kooy – volume: 11 start-page: 213 year: 2001 end-page: 221 ident: bib10 article-title: An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control publication-title: Curr. Biol. contributor: fullname: Hafen – volume: 13 start-page: 98 year: 1999 end-page: 111 ident: bib12 article-title: The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development publication-title: Genes Dev. contributor: fullname: O'Connor – volume: 88 start-page: 332 year: 2004 end-page: 347 ident: bib3 article-title: Cell cycle kinetics of expanding populations of neural stem and progenitor cells in vitro publication-title: Biotechnol. Bioeng. contributor: fullname: Kallos – volume: 2 start-page: 239 year: 2002 end-page: 249 ident: bib9 article-title: Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions publication-title: Dev. Cell contributor: fullname: Edgar – volume: 24 start-page: 23 year: 2003 end-page: 40 ident: bib1 article-title: IGF-I has a direct proliferative effect in adult hippocampal progenitor cells publication-title: Mol. Cell. Neurosci. contributor: fullname: Eriksson – volume: 132 start-page: 645 year: 2008 end-page: 660 ident: bib78 article-title: Mechanisms and functional implications of adult neurogenesis publication-title: Cell contributor: fullname: Gage – volume: 96 start-page: 11619 year: 1999 end-page: 11624 ident: bib17 article-title: Regeneration of a germinal layer in the adult mammalian brain publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Alvarez-Buylla – volume: 23 start-page: 3325 year: 2003 end-page: 3335 ident: bib19 article-title: Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development publication-title: J. Neurosci. contributor: fullname: Hartenstein – volume: 125 start-page: 145 year: 1988 end-page: 157 ident: bib68 article-title: Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster publication-title: Dev. Biol. contributor: fullname: Bate – volume: 74 start-page: 15 year: 1993 end-page: 27 ident: bib20 article-title: The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation publication-title: Cell contributor: fullname: Zipursky – volume: 132 start-page: 583 year: 2008 end-page: 597 ident: bib37 article-title: Mechanisms of asymmetric stem cell division publication-title: Cell contributor: fullname: Knoblich – volume: 6 start-page: e1000990 year: 2010 ident: bib38 article-title: Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling publication-title: PLoS Genet. contributor: fullname: Perrimon – volume: 273 start-page: 13375 year: 1998 end-page: 13378 ident: bib45 article-title: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate publication-title: J. Biol. Chem. contributor: fullname: Dixon – volume: 3 start-page: e3721 year: 2008 ident: bib11 article-title: Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs publication-title: PLoS ONE contributor: fullname: Partridge – volume: 196 start-page: 473 year: 1987 end-page: 485 ident: bib31 article-title: The pattern of proliferation of the neuroblasts in the wild-type embryo of publication-title: Rouxs Arch. Dev. Biol. contributor: fullname: Campos-Ortega – volume: 238 start-page: 47 year: 2001 end-page: 63 ident: bib61 article-title: Peripheral glia direct axon guidance across the CNS/PNS transition zone publication-title: Dev. Biol. contributor: fullname: Auld – volume: 8 start-page: 1638 year: 1988 ident: 10.1016/j.cell.2010.12.007_bib25 article-title: Tissue localization of Drosophila melanogaster insulin receptor transcripts during development publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.8.4.1638 contributor: fullname: Garofalo – volume: 106 start-page: 511 year: 2001 ident: 10.1016/j.cell.2010.12.007_bib34 article-title: Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny publication-title: Cell doi: 10.1016/S0092-8674(01)00465-2 contributor: fullname: Isshiki – volume: 135 start-page: 513 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib79 article-title: Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain publication-title: Development doi: 10.1242/dev.010876 contributor: fullname: Zhu – volume: 103 start-page: 111 year: 2006 ident: 10.1016/j.cell.2010.12.007_bib30 article-title: PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0509939103 contributor: fullname: Groszer – volume: 2 start-page: 233 year: 2006 ident: 10.1016/j.cell.2010.12.007_bib53 article-title: The realized niche of adult neural stem cells publication-title: Stem Cell Rev. doi: 10.1007/s12015-006-0051-6 contributor: fullname: Nern – volume: 125 start-page: 145 year: 1988 ident: 10.1016/j.cell.2010.12.007_bib68 article-title: Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster publication-title: Dev. Biol. doi: 10.1016/0012-1606(88)90067-X contributor: fullname: Truman – volume: 71 start-page: 375 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib27 article-title: The functions of insulin signaling: size isn't everything, even in Drosophila publication-title: Differentiation doi: 10.1046/j.1432-0436.2003.7107001.x contributor: fullname: Goberdhan – volume: 23 start-page: 9117 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib49 article-title: Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.24.9117-9126.2003 contributor: fullname: Miron – volume: 295 start-page: 2088 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib66 article-title: Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB publication-title: Science doi: 10.1126/science.1068094 contributor: fullname: Stocker – ident: 10.1016/j.cell.2010.12.007_bib85 doi: 10.1093/nar/gkh014 – volume: 34 start-page: 115 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib62 article-title: PPTGAL, a convenient Gal4 P-element vector for testing expression of enhancer fragments in drosophila publication-title: Genesis doi: 10.1002/gene.10127 contributor: fullname: Sharma – volume: 17 start-page: 874 year: 2009 ident: 10.1016/j.cell.2010.12.007_bib64 article-title: A Drosophila insulin-like peptide promotes growth during nonfeeding states publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.10.009 contributor: fullname: Slaidina – volume: 13 start-page: 3244 year: 1999 ident: 10.1016/j.cell.2010.12.007_bib28 article-title: Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway publication-title: Genes Dev. doi: 10.1101/gad.13.24.3244 contributor: fullname: Goberdhan – volume: 51 start-page: 173 year: 2005 ident: 10.1016/j.cell.2010.12.007_bib63 article-title: Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes publication-title: Glia doi: 10.1002/glia.20187 contributor: fullname: Shetty – ident: 10.1016/j.cell.2010.12.007_bib84 doi: 10.1016/S0960-9822(02)01043-6 – volume: 13 start-page: 98 year: 1999 ident: 10.1016/j.cell.2010.12.007_bib12 article-title: The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development publication-title: Genes Dev. doi: 10.1101/gad.13.1.98 contributor: fullname: Brummel – volume: 14 start-page: 3373 year: 1995 ident: 10.1016/j.cell.2010.12.007_bib22 article-title: The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential publication-title: EMBO J. doi: 10.1002/j.1460-2075.1995.tb07343.x contributor: fullname: Fernandez – volume: 6 start-page: e1000990 year: 2010 ident: 10.1016/j.cell.2010.12.007_bib38 article-title: Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000990 contributor: fullname: Kockel – volume: 374 start-page: 297 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib42 article-title: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B publication-title: Biochem. J. doi: 10.1042/bj20030577 contributor: fullname: Lizcano – volume: 132 start-page: 583 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib37 article-title: Mechanisms of asymmetric stem cell division publication-title: Cell doi: 10.1016/j.cell.2008.02.007 contributor: fullname: Knoblich – volume: 10 start-page: 199 year: 2009 ident: 10.1016/j.cell.2010.12.007_bib26 article-title: Remote control of insulin secretion by fat cells in Drosophila publication-title: Cell Metab. doi: 10.1016/j.cmet.2009.08.002 contributor: fullname: Géminard – ident: 10.1016/j.cell.2010.12.007_bib80 doi: 10.1016/S1534-5807(02)00117-X – volume: 96 start-page: 11619 year: 1999 ident: 10.1016/j.cell.2010.12.007_bib17 article-title: Regeneration of a germinal layer in the adult mammalian brain publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.96.20.11619 contributor: fullname: Doetsch – volume: 296 start-page: 1118 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib60 article-title: Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes publication-title: Science doi: 10.1126/science.1070058 contributor: fullname: Rulifson – volume: 592 start-page: 343 year: 1992 ident: 10.1016/j.cell.2010.12.007_bib24 article-title: Expression of insulin-like growth factor I by astrocytes in response to injury publication-title: Brain Res. doi: 10.1016/0006-8993(92)91695-B contributor: fullname: Garcia-Estrada – volume: 121 start-page: 2975 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib77 article-title: All muscle satellite cells are equal, but are some more equal than others? publication-title: J. Cell Sci. doi: 10.1242/jcs.019661 contributor: fullname: Zammit – volume: 196 start-page: 473 year: 1987 ident: 10.1016/j.cell.2010.12.007_bib31 article-title: The pattern of proliferation of the neuroblasts in the wild-type embryo of Drosophila melanogaster publication-title: Rouxs Arch. Dev. Biol. doi: 10.1007/BF00399871 contributor: fullname: Hartenstein – volume: 253 start-page: 247 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib56 article-title: Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division publication-title: Dev. Biol. doi: 10.1016/S0012-1606(02)00019-2 contributor: fullname: Park – volume: 6 start-page: 2137 year: 1992 ident: 10.1016/j.cell.2010.12.007_bib7 article-title: deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product publication-title: Genes Dev. doi: 10.1101/gad.6.11.2137 contributor: fullname: Bier – volume: 238 start-page: 47 year: 2001 ident: 10.1016/j.cell.2010.12.007_bib61 article-title: Peripheral glia direct axon guidance across the CNS/PNS transition zone publication-title: Dev. Biol. doi: 10.1006/dbio.2001.0411 contributor: fullname: Sepp – ident: 10.1016/j.cell.2010.12.007_bib93 doi: 10.1016/S0960-9822(99)80450-3 – ident: 10.1016/j.cell.2010.12.007_bib88 doi: 10.1016/S0896-6273(00)80701-1 – ident: 10.1016/j.cell.2010.12.007_bib86 doi: 10.1002/neu.1018 – volume: 6 start-page: e1000857 year: 2010 ident: 10.1016/j.cell.2010.12.007_bib29 article-title: Molecular evolution and functional characterization of Drosophila insulin-like peptides publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000857 contributor: fullname: Grönke – volume: 273 start-page: 13375 year: 1998 ident: 10.1016/j.cell.2010.12.007_bib45 article-title: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.22.13375 contributor: fullname: Maehama – volume: 17 start-page: 6727 year: 1997 ident: 10.1016/j.cell.2010.12.007_bib70 article-title: Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.11.6727 contributor: fullname: Uv – volume: 15 start-page: 514 year: 2005 ident: 10.1016/j.cell.2010.12.007_bib43 article-title: Glial influences on neural stem cell development: cellular niches for adult neurogenesis publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2005.08.003 contributor: fullname: Ma – volume: 132 start-page: 645 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib78 article-title: Mechanisms and functional implications of adult neurogenesis publication-title: Cell doi: 10.1016/j.cell.2008.01.033 contributor: fullname: Zhao – volume: 29 start-page: 775 year: 2009 ident: 10.1016/j.cell.2010.12.007_bib46 article-title: Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1700-08.2009 contributor: fullname: Mairet-Coello – volume: 1 start-page: 500 year: 1999 ident: 10.1016/j.cell.2010.12.007_bib71 article-title: Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB publication-title: Nat. Cell Biol. doi: 10.1038/70293 contributor: fullname: Verdu – ident: 10.1016/j.cell.2010.12.007_bib89 doi: 10.1002/j.1460-2075.1996.tb01049.x – volume: 267 start-page: 3149 year: 2000 ident: 10.1016/j.cell.2010.12.007_bib23 article-title: Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression publication-title: Eur. J. Biochem. doi: 10.1046/j.1432-1327.2000.01337.x contributor: fullname: Friedrich – volume: 7 start-page: 121 year: 2007 ident: 10.1016/j.cell.2010.12.007_bib41 article-title: The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts publication-title: BMC Dev. Biol. doi: 10.1186/1471-213X-7-121 contributor: fullname: Lindner – volume: 3 start-page: e3721 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib11 article-title: Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs publication-title: PLoS ONE doi: 10.1371/journal.pone.0003721 contributor: fullname: Broughton – volume: 74 start-page: 99 year: 1998 ident: 10.1016/j.cell.2010.12.007_bib57 article-title: Homeotic regulation of segment-specific differences in neuroblast numbers and proliferation in the Drosophila central nervous system publication-title: Mech. Dev. doi: 10.1016/S0925-4773(98)00068-9 contributor: fullname: Prokop – volume: 78 start-page: 472 year: 2004 ident: 10.1016/j.cell.2010.12.007_bib76 article-title: Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression publication-title: J. Neurosci. Res. doi: 10.1002/jnr.20288 contributor: fullname: Ye – ident: 10.1016/j.cell.2010.12.007_bib90 doi: 10.1126/science.1089035 – volume: 13 start-page: 1071 year: 1994 ident: 10.1016/j.cell.2010.12.007_bib52 article-title: Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells publication-title: Neuron doi: 10.1016/0896-6273(94)90046-9 contributor: fullname: Morshead – volume: 118 start-page: 3585 year: 2005 ident: 10.1016/j.cell.2010.12.007_bib74 article-title: On mammary stem cells publication-title: J. Cell Sci. doi: 10.1242/jcs.02532 contributor: fullname: Woodward – volume: 98 start-page: 6144 year: 2001 ident: 10.1016/j.cell.2010.12.007_bib13 article-title: Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.101596998 contributor: fullname: Cho – volume: 111 start-page: 79 year: 1991 ident: 10.1016/j.cell.2010.12.007_bib58 article-title: The origin of postembryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster publication-title: Development doi: 10.1242/dev.111.1.79 contributor: fullname: Prokop – ident: 10.1016/j.cell.2010.12.007_bib91 doi: 10.1006/dbio.2001.0411 – volume: 133 start-page: 891 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib47 article-title: Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila publication-title: Cell doi: 10.1016/j.cell.2008.03.034 contributor: fullname: Maurange – volume: 9 start-page: 1019 year: 1999 ident: 10.1016/j.cell.2010.12.007_bib73 article-title: Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor publication-title: Curr. Biol. doi: 10.1016/S0960-9822(99)80450-3 contributor: fullname: Weinkove – ident: 10.1016/j.cell.2010.12.007_bib87 doi: 10.1016/j.cub.2005.04.054 – ident: 10.1016/j.cell.2010.12.007_bib92 doi: 10.1126/science.1068094 – volume: 317 start-page: 234 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib6 article-title: Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2008.02.025 contributor: fullname: Barrett – volume: 417 start-page: 39 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib65 article-title: Astroglia induce neurogenesis from adult neural stem cells publication-title: Nature doi: 10.1038/417039a contributor: fullname: Song – volume: 19 start-page: 672 year: 2009 ident: 10.1016/j.cell.2010.12.007_bib44 article-title: Adult neural stem cells in the mammalian central nervous system publication-title: Cell Res. doi: 10.1038/cr.2009.56 contributor: fullname: Ma – ident: 10.1016/j.cell.2010.12.007_bib82 doi: 10.1371/journal.pgen.1000857 – volume: 224 start-page: 403 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib72 article-title: Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts publication-title: Dev. Dyn. doi: 10.1002/dvdy.10120 contributor: fullname: Voigt – volume: 437 start-page: 894 year: 2005 ident: 10.1016/j.cell.2010.12.007_bib2 article-title: In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog publication-title: Nature doi: 10.1038/nature03994 contributor: fullname: Ahn – volume: 24 start-page: 45 year: 2006 ident: 10.1016/j.cell.2010.12.007_bib75 article-title: Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2006.04872.x contributor: fullname: Yan – volume: 98 start-page: 15020 year: 2001 ident: 10.1016/j.cell.2010.12.007_bib59 article-title: PDK1 regulates growth through Akt and S6K in Drosophila publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.011318098 contributor: fullname: Rintelen – volume: 23 start-page: 3325 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib19 article-title: Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-08-03325.2003 contributor: fullname: Dumstrei – volume: 126 start-page: 5365 year: 1999 ident: 10.1016/j.cell.2010.12.007_bib32 article-title: PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development publication-title: Development doi: 10.1242/dev.126.23.5365 contributor: fullname: Huang – volume: 73 start-page: 403 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib5 article-title: Signaling pathways controlling neural stem cells slow progressive brain disease publication-title: Cold Spring Harb. Symp. Quant. Biol. doi: 10.1101/sqb.2008.73.018 contributor: fullname: Androutsellis-Theotokis – volume: 129 start-page: 4103 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib55 article-title: The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels publication-title: Development doi: 10.1242/dev.129.17.4103 contributor: fullname: Oldham – volume: 135 start-page: 3859 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib69 article-title: Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors publication-title: Development doi: 10.1242/dev.025189 contributor: fullname: Tsuji – volume: 88 start-page: 332 year: 2004 ident: 10.1016/j.cell.2010.12.007_bib3 article-title: Cell cycle kinetics of expanding populations of neural stem and progenitor cells in vitro publication-title: Biotechnol. Bioeng. doi: 10.1002/bit.20246 contributor: fullname: Alam – volume: 2 start-page: 239 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib9 article-title: Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions publication-title: Dev. Cell doi: 10.1016/S1534-5807(02)00117-X contributor: fullname: Britton – volume: 11 start-page: 213 year: 2001 ident: 10.1016/j.cell.2010.12.007_bib10 article-title: An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00068-9 contributor: fullname: Brogiolo – volume: 302 start-page: 1765 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib48 article-title: Spatiotemporal rescue of memory dysfunction in Drosophila publication-title: Science doi: 10.1126/science.1089035 contributor: fullname: McGuire – volume: 28 start-page: 587 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib67 article-title: Organization and function of the blood-brain barrier in Drosophila publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4367-07.2008 contributor: fullname: Stork – ident: 10.1016/j.cell.2010.12.007_bib81 doi: 10.1534/genetics.106.065961 – volume: 134 start-page: 115 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib4 article-title: Insulin-like growth factor-I and neurogenesis in the adult mammalian brain publication-title: Brain Res. Dev. Brain Res. doi: 10.1016/S0165-3806(02)00277-8 contributor: fullname: Anderson – volume: 12 start-page: 1293 year: 2002 ident: 10.1016/j.cell.2010.12.007_bib33 article-title: Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)01043-6 contributor: fullname: Ikeya – volume: 15 start-page: 6584 year: 1996 ident: 10.1016/j.cell.2010.12.007_bib40 article-title: The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth publication-title: EMBO J. doi: 10.1002/j.1460-2075.1996.tb01049.x contributor: fullname: Leevers – volume: 74 start-page: 15 year: 1993 ident: 10.1016/j.cell.2010.12.007_bib20 article-title: The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation publication-title: Cell doi: 10.1016/0092-8674(93)90291-W contributor: fullname: Ebens – volume: 363 start-page: 39 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib21 article-title: Insights into neural stem cell biology from flies publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2006.2011 contributor: fullname: Egger – volume: 121 start-page: 1173 year: 1995 ident: 10.1016/j.cell.2010.12.007_bib16 article-title: Control of proliferation activation in quiescent neuroblasts of the Drosophila central nervous system publication-title: Development doi: 10.1242/dev.121.4.1173 contributor: fullname: Datta – volume: 309 start-page: 1071 year: 2005 ident: 10.1016/j.cell.2010.12.007_bib39 article-title: Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila publication-title: Science doi: 10.1126/science.1111410 contributor: fullname: LaFever – volume: 24 start-page: 23 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib1 article-title: IGF-I has a direct proliferative effect in adult hippocampal progenitor cells publication-title: Mol. Cell. Neurosci. doi: 10.1016/S1044-7431(03)00082-4 contributor: fullname: Aberg – volume: 125 start-page: 2149 year: 1998 ident: 10.1016/j.cell.2010.12.007_bib8 article-title: Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms publication-title: Development doi: 10.1242/dev.125.11.2149 contributor: fullname: Britton – volume: 4 start-page: e83 year: 2006 ident: 10.1016/j.cell.2010.12.007_bib14 article-title: A new description of cellular quiescence publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0040083 contributor: fullname: Coller – volume: 149 start-page: 5958 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib36 article-title: Expanding the mind: insulin-like growth factor I and brain development publication-title: Endocrinology doi: 10.1210/en.2008-0920 contributor: fullname: Joseph D'Ercole – volume: 132 start-page: 598 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib51 article-title: Stem cells and niches: mechanisms that promote stem cell maintenance throughout life publication-title: Cell doi: 10.1016/j.cell.2008.01.038 contributor: fullname: Morrison – volume: 17 start-page: 885 year: 2009 ident: 10.1016/j.cell.2010.12.007_bib54 article-title: A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.10.008 contributor: fullname: Okamoto – volume: 311 start-page: 1880 year: 2006 ident: 10.1016/j.cell.2010.12.007_bib50 article-title: Stem cells and their niches publication-title: Science doi: 10.1126/science.1110542 contributor: fullname: Moore – ident: 10.1016/j.cell.2010.12.007_bib83 doi: 10.1242/dev.126.23.5365 – volume: 149 start-page: 134 year: 1992 ident: 10.1016/j.cell.2010.12.007_bib35 article-title: Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogaster publication-title: Dev. Biol. doi: 10.1016/0012-1606(92)90270-Q contributor: fullname: Ito – volume: 180 start-page: 1787 year: 2008 ident: 10.1016/j.cell.2010.12.007_bib18 article-title: Stem cells, their niches and the systemic environment: an aging network publication-title: Genetics doi: 10.1534/genetics.108.098244 contributor: fullname: Drummond-Barbosa – volume: 114 start-page: 739 year: 2003 ident: 10.1016/j.cell.2010.12.007_bib15 article-title: A nutrient sensor mechanism controls Drosophila growth publication-title: Cell doi: 10.1016/S0092-8674(03)00713-X contributor: fullname: Colombani |
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| SubjectTerms | Animals BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Cell Biology Diet Drosophila Drosophila - cytology Drosophila - embryology Drosophila - metabolism Fat Body - metabolism Gene Expression Regulation, Developmental Neural Stem Cells - cytology Neuroglia - cytology Somatomedins - metabolism |
| Title | Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence |
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