Delving into Matrix Metalloproteinase-1 (MMP-1) and its Significance in Periodontal Diseases

• Published in: Journal of pharmacy & bioallied science Vol. 16; no. Suppl 2; pp. S1080 - S1083
• Main Authors: Natarajan, Prabhu M, Ganesan, Anuradha, Varma, Sudhir R, Shetty, Naresh Y
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-04-2024; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Alveolar bone; alveolar bone resorption; biomarkers; Bone resorption; Collagen; Collagen (type I); Development and progression; Diseases; extracellular matrix remodeling; gingival tissues; Homeostasis; host modulation therapy; Interstitial collagenase; Matrix metalloproteinase; matrix metalloproteinase-1 (mmp-1); Metalloproteinase; molecular mechanisms; Periodontal disease; Periodontal diseases; Periodontitis; Periodontium; personalized treatment; Review; Root resorption; targeted therapeutics; Tetracycline; Tetracyclines; molecular mechanisms; host modulation therapy; biomarkers; matrix metalloproteinase-1 (MMP-1); periodontitis; Alveolar bone resorption; periodontal diseases; gingival tissues; personalized treatment; targeted therapeutics; extracellular matrix remodeling
• ISSN: 0976-4879; 0975-7406
• DOI: 10.4103/jpbs.jpbs_1249_23

Matrix metalloproteinase-1 (MMP-1) plays a pivotal role in the pathogenesis of periodontal diseases, particularly periodontitis, by virtue of its collagenolytic activity targeting collagen type I, the primary component of periodontal tissues. This review abstract elucidates the intricate involvement of MMP-1 in periodontal tissue homeostasis and its dysregulation in disease states. Elevated MMP-1 levels, observed in gingival tissues and crevicular fluid of individuals with periodontitis, correlate with the degradation of collagen fibers within the periodontium. This degradation contributes to the detachment of teeth from surrounding tissues and exacerbates alveolar bone resorption, hallmark features of periodontal breakdown. Therapeutically, targeting MMP-1 activity emerges as a promising strategy, prompting ongoing research into MMP inhibitors and host modulation therapies. Understanding MMP-1's nuanced role in periodontal diseases paves the way for personalized treatment approaches and holds promise in reshaping periodontal disease management for improved patient outcomes and periodontal health.