Infections and systemic lupus erythematosus
To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. An analytical retrospective study using data from medica...
Saved in:
| Published in: | Einstein (São Paulo, Brazil) Vol. 14; no. 1; pp. 47 - 51 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Brazil
Instituto Israelita de Ensino e Pesquisa Albert Einstein
01-01-2016
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment.
An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site.
The most frequent infections were urinary tract infections (correlated to use of prednisone - p<0.0001 and cyclophosphamide - p=0.045), upper airways infections (correlated to use of prednisone - p=0.0004, mycophenolate mofetil - p=0.0005, and cyclosporine - p=0.025), and pneumonia (associated to prednisone - p=0.017).
Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. |
|---|---|
| AbstractList | ABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. Methods An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. Results The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). Conclusion Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. The most frequent infections were urinary tract infections (correlated to use of prednisone - p<0.0001 and cyclophosphamide - p=0.045), upper airways infections (correlated to use of prednisone - p=0.0004, mycophenolate mofetil - p=0.0005, and cyclosporine - p=0.025), and pneumonia (associated to prednisone - p=0.017). Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. ABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. Methods An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. Results The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). Conclusion Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. RESUMO Objetivo Determinar a incidência de infecções em uma população com lúpus eritematoso sistêmico e a caracterização das mesmas quanto aos locais de origem, assim como estudar possíveis associações das infecções com a terapêutica utilizada. Métodos Estudo retrospectivo analítico utilizando dados de prontuários de indivíduos com lúpus eritematoso sistêmico de um único hospital universitário. Foram investigados 144 pacientes acompanhados pelo período de 5 anos. Os dados coletados incluíam idade do paciente e idade de início do lúpus, sexo e etnia, tempo de duração da doença antes do período do estudo, medicamentos administrados, dose cumulativa de prednisona, ocorrência de infecções e seu local de origem. Resultados As infecções mais observadas foram as do trato urinário (correlacionadas com o uso de prednisona − p<0,0001, e ciclofosfamida − p=0,045), infecções das vias aéreas superiores (correlacionadas com o uso de prednisona − p=0,0004, micofenolato de mofetila − p=0,0005 e ciclosporina − p=0,025) e pneumonia (correlacionadas ao uso de prednisona − p=0,017). Conclusão A prednisona foi o medicamento mais associado com a presença de infecções, apontando para a necessidade de um manejo mais judicioso desse medicamento. |
| Author | Nisihara, Renato Mitsunori Skare, Thelma Larocca Dagostini, Jéssica Scherer Zanardi, Patricia Imai |
| AuthorAffiliation | 1 Faculdade Evangélica do Paraná, Curitiba, PR, Brazil 2 Universidade Positivo, Curitiba, PR, Brazil |
| AuthorAffiliation_xml | – name: 2 Universidade Positivo, Curitiba, PR, Brazil – name: 1 Faculdade Evangélica do Paraná, Curitiba, PR, Brazil – name: Faculdade Evangélica do Paraná – name: Universidade Positivo |
| Author_xml | – sequence: 1 givenname: Thelma Larocca surname: Skare fullname: Skare, Thelma Larocca organization: Faculdade Evangélica do Paraná, Curitiba, PR, Brazil – sequence: 2 givenname: Jéssica Scherer surname: Dagostini fullname: Dagostini, Jéssica Scherer organization: Faculdade Evangélica do Paraná, Curitiba, PR, Brazil – sequence: 3 givenname: Patricia Imai surname: Zanardi fullname: Zanardi, Patricia Imai organization: Faculdade Evangélica do Paraná, Curitiba, PR, Brazil – sequence: 4 givenname: Renato Mitsunori surname: Nisihara fullname: Nisihara, Renato Mitsunori organization: Universidade Positivo, Curitiba, PR, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27074234$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkU1P3DAQhi1EVRbaf4DQ3lHoeOzYzgUJIWhXQuLQ9mw5zhiyysYrO0Haf0-WwKr0YFn-eJ4ZzXvKjvvYE2PnHK54WcGP31zpqpAlGASubh6FrOCILVBwXShhymO2OPw4Yac5rwEUV6b6yk5Qg5Yo5IJdrvpAfmhjn5eub5Z5lwfatH7ZjdsxLynthmfauCHmMX9jX4LrMn1_38_Y3_u7P7e_iofHn6vbm4fCl1wMhVRBU4nGoAqq5NPBaTRCEPqayGuovEfUBhEEksAahWuCqT1yV9beiTO2mr1NdGu7Te3GpZ2NrrVvFzE9WZeG1ndkQTVICgKf9DJIUzcyaMch6JqH2vDJdTW7sm-pi3Ydx9RPzdu38dmP8QEAn5bUE3A9A9ux3lDjqR-S6z518fmlb5_tU3yx0mis-F4gZ4FPMedE4cBysPvk_is9JzdhF__WPUAfUYlX6X-UQA |
| CitedBy_id | crossref_primary_10_47456_bjpe_v9i1_39945 crossref_primary_10_1016_j_biopha_2019_109122 crossref_primary_10_1177_09612033221135884 crossref_primary_10_3233_CH_180492 crossref_primary_10_4103_injr_injr_65_21 crossref_primary_10_1007_s00296_023_05370_x crossref_primary_10_1016_j_rcreue_2020_07_003 crossref_primary_10_1002_ccr3_5265 crossref_primary_10_1177_0961203319882498 crossref_primary_10_1016_j_rcreu_2020_07_005 |
| Cites_doi | 10.1016/j.autrev.2015.07.003 10.1191/0961203302lu170oa 10.1080/00365540902744741 10.1097/RHU.0b013e3181d52ed7 10.1191/096120301671376017 10.1177/0961203310374486 10.1186/ar2764 10.1177/0961203314543918 10.1016/0002-9343(76)90431-9 10.1191/096120301675075008 10.1016/j.clinthera.2013.03.001 10.1177/0961203315588575 10.1191/0961203305LU2111OA 10.1016/j.rdc.2009.03.003 10.1177/0961203313493032 10.1177/0961203312470186 10.1177/0961203313490434 10.1177/0961203307086503 10.1177/0961203307077987 10.1002/art.1780400928 10.1177/0961203308093458 10.1177/0961203306071919 10.1191/0961203303lu1028oa 10.1016/j.medmal.2007.07.003 10.1177/0961203309345776 |
| ContentType | Journal Article |
| Copyright | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Copyright_xml | – notice: This work is licensed under a Creative Commons Attribution 4.0 International License. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM GPN DOA |
| DOI | 10.1590/S1679-45082016AO3490 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) SciELO Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Infecções e lúpus eritematoso sistêmico |
| EISSN | 2317-6385 1679-4508 |
| EndPage | 51 |
| ExternalDocumentID | oai_doaj_org_article_06d2e60f133e4f48bd4f7a10f7b1fb81 S1679_45082016000100047 10_1590_S1679_45082016AO3490 27074234 |
| Genre | Journal Article |
| GroupedDBID | 1CY 29G 2WC 53G 5GY ABDBF ABDHV ABXHO ADBBV ADRAZ ALMA_UNASSIGNED_HOLDINGS AOIJS APOWU AZFZN BAWUL BCNDV C1A CGR CUY CVF DIK E3Z EBD ECM EIF EMOBN ESX GROUPED_DOAJ HYE IPNFZ KQ8 M48 MK0 M~E NPM OK1 PGMZT RIG RNS RPM RSC SCD SV3 AAYXX CITATION 5PM GPN |
| ID | FETCH-LOGICAL-c513t-46f7e528826f651f7ea72833e2cbeec709cc227822032e32b23adf8bc21a5bca3 |
| IEDL.DBID | RPM |
| ISSN | 1679-4508 2317-6385 |
| IngestDate | Tue Oct 22 14:55:46 EDT 2024 Tue Nov 19 21:48:28 EST 2024 Tue Sep 17 21:20:26 EDT 2024 Fri Nov 22 00:47:51 EST 2024 Sat Nov 02 12:29:35 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Infecções urinárias/etiologia systemic/complications Imunossupressão Immunosuppression Urinary tract infection/etiology Lupus eryithematosus Lúpus eritematoso sistêmico/complicações |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c513t-46f7e528826f651f7ea72833e2cbeec709cc227822032e32b23adf8bc21a5bca3 |
| Notes | Conflict of interest: none. |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872917/ |
| PMID | 27074234 |
| PageCount | 5 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_06d2e60f133e4f48bd4f7a10f7b1fb81 scielo_journals_S1679_45082016000100047 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4872917 crossref_primary_10_1590_S1679_45082016AO3490 pubmed_primary_27074234 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-01-01 |
| PublicationDateYYYYMMDD | 2016-01-01 |
| PublicationDate_xml | – month: 01 year: 2016 text: 2016-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Brazil |
| PublicationPlace_xml | – name: Brazil |
| PublicationTitle | Einstein (São Paulo, Brazil) |
| PublicationTitleAlternate | Einstein (Sao Paulo) |
| PublicationYear | 2016 |
| Publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| Publisher_xml | – name: Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| References | Danza A (ref7) 2013; 22 Chatham WW (ref16) 2001; 10 Jeong SJ (ref9) 2009; 41 Khalifa M (ref5) 2007; 37 Relle M (ref11) 2015; 14 Petri M (ref21) 2004; 13 Nossent J (ref2) 2007; 16 Sisó A (ref12) 2008; 17 Koh JH (ref22) 2015; 21 Navarra SV (ref4) 2010; 19 Skare TL (ref1) 2007 Luijten RK (ref13) 2014; 23 Urowitz MB (ref3) 1976; 60 Navarro-Zarza JE (ref15) 2010; 19 Gladman DD (ref19) 2002; 11 Borba EF (ref26) 2010; 16 Bosch X (ref8) 2006; 15 Zahr ZA (ref18) 2013; 22 Chakravarty EF (ref25) 2013; 22 Ruiz-Irastorza G (ref14) 2009; 11 Pisoni CN (ref24) 2005; 14 Hochberg MC (ref10) 1997; 40 Shah M (ref17) 2013; 35 Duran-Barragan S (ref23) 2008; 17 Takada K (ref20) 2001; 10 Cuchacovich R (ref6) 2009; 35 2009; 11 2009; 35 2015; 14 2009; 41 1997; 40 2010; 16 2013; 22 2010; 19 2013; 35 1976; 60 2006; 15 2008; 17 2002; 11 2004; 13 2015; 21 Skare, TL 2007 2014; 23 2007; 37 2007; 16 2001; 10 2005; 14 |
| References_xml | – volume: 14 start-page: 1005 issue: 11 year: 2015 ident: ref11 article-title: Genetics and novel aspects of therapies in systemic lupus erythematosus publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2015.07.003 contributor: fullname: Relle M – volume: 11 start-page: 234 issue: 4 year: 2002 ident: ref19 article-title: The nature and outcome of infection in systemic lupus erythematosus publication-title: Lupus doi: 10.1191/0961203302lu170oa contributor: fullname: Gladman DD – volume: 41 start-page: 268 issue: 4 year: 2009 ident: ref9 article-title: Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus publication-title: Scand J Infect Dis doi: 10.1080/00365540902744741 contributor: fullname: Jeong SJ – volume: 16 start-page: 119 issue: 3 year: 2010 ident: ref26 article-title: Incidence, risk factors, and outcome of Herpes zoster in systemic lupus erythematosus publication-title: J Clin Rheumatol doi: 10.1097/RHU.0b013e3181d52ed7 contributor: fullname: Borba EF – volume: 10 start-page: 154 issue: 3 year: 2001 ident: ref20 article-title: Cyclophosphamide for the treatment of systemic lupus erythematosus publication-title: Lupus doi: 10.1191/096120301671376017 contributor: fullname: Takada K – volume: 19 start-page: 1419 issue: 12 year: 2010 ident: ref4 article-title: Infections in systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203310374486 contributor: fullname: Navarra SV – volume: 11 issue: 4 year: 2009 ident: ref14 article-title: Predictors of major infections in systemic lupus erythematosus publication-title: Arthritis Res Ther doi: 10.1186/ar2764 contributor: fullname: Ruiz-Irastorza G – volume: 23 start-page: 1512 issue: 14 year: 2014 ident: ref13 article-title: Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections publication-title: Lupus doi: 10.1177/0961203314543918 contributor: fullname: Luijten RK – volume: 60 start-page: 221 issue: 2 year: 1976 ident: ref3 article-title: The bimodal mortality pattern of systemic lupus erythematosus publication-title: Am J Med doi: 10.1016/0002-9343(76)90431-9 contributor: fullname: Urowitz MB – volume: 10 start-page: 140 issue: 3 year: 2001 ident: ref16 article-title: Treatment of lupus with corticosteroids publication-title: Lupus doi: 10.1191/096120301675075008 contributor: fullname: Chatham WW – volume: 35 start-page: 486 issue: 4 year: 2013 ident: ref17 article-title: Cumulative burden of oral corticosteroid adverse effects and the economic implications of corticosteroid use in patients whit systemic lupus erythematosus publication-title: Clin Ther doi: 10.1016/j.clinthera.2013.03.001 contributor: fullname: Shah M – year: 2007 ident: ref1 contributor: fullname: Skare TL – volume: 21 start-page: 1300 issue: 12 year: 2015 ident: ref22 article-title: Lupus cystitis in Korean patients with systemic lupus erythematosus: risk factors and clinical outcomes publication-title: Lupus doi: 10.1177/0961203315588575 contributor: fullname: Koh JH – volume: 14 start-page: s9 year: 2005 ident: ref24 article-title: Mycophenolate mofetil and systemic lupus erythematosus: an overview publication-title: Lupus doi: 10.1191/0961203305LU2111OA contributor: fullname: Pisoni CN – volume: 35 start-page: 75 issue: 1 year: 2009 ident: ref6 article-title: Pathophysiology and clinical spectrum of infections in systemic lupus erythematosus publication-title: Rheum Dis Clin North Am doi: 10.1016/j.rdc.2009.03.003 contributor: fullname: Cuchacovich R – volume: 22 start-page: 1286 issue: 12 year: 2013 ident: ref7 article-title: Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies publication-title: Lupus doi: 10.1177/0961203313493032 contributor: fullname: Danza A – volume: 22 start-page: 238 issue: 3 year: 2013 ident: ref25 article-title: Increased incidence of herpes zoster among patients with systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203312470186 contributor: fullname: Chakravarty EF – volume: 22 start-page: 697 issue: 7 year: 2013 ident: ref18 article-title: Predictors of corticosteroid tapering in SLE patients: the Hopkins Lupus Cohort publication-title: Lupus doi: 10.1177/0961203313490434 contributor: fullname: Zahr ZA – volume: 17 start-page: 281 issue: 4 year: 2008 ident: ref12 article-title: Previous antimalarial therapy in patients diagnosed with lupus nephritis: influence on outcomes and survival publication-title: Lupus doi: 10.1177/0961203307086503 contributor: fullname: Sisó A – volume: 16 start-page: 309 issue: 5 year: 2007 ident: ref2 article-title: Current causes of death in systemic lupus erythematosus in Europe, 2000--2004: relation to disease activity and damage accrual publication-title: Lupus doi: 10.1177/0961203307077987 contributor: fullname: Nossent J – volume: 40 issue: 9 year: 1997 ident: ref10 article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.1780400928 contributor: fullname: Hochberg MC – volume: 17 start-page: 1117 issue: 12 year: 2008 ident: ref23 article-title: Recurrent urinary tract infections and bladder dysfunction in systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203308093458 contributor: fullname: Duran-Barragan S – volume: 15 start-page: 584 issue: 9 year: 2006 ident: ref8 article-title: Infections in systemic lupus erythematosus: a prospective and controlled study of 110 patients publication-title: Lupus doi: 10.1177/0961203306071919 contributor: fullname: Bosch X – volume: 13 start-page: 366 issue: 5 year: 2004 ident: ref21 article-title: Cyclophosphamide: new approaches for systemic lupus erythematosus publication-title: Lupus doi: 10.1191/0961203303lu1028oa contributor: fullname: Petri M – volume: 37 start-page: 792 issue: 12 year: 2007 ident: ref5 article-title: Infections in systemic lupus erythematosus publication-title: Med Mal Infect doi: 10.1016/j.medmal.2007.07.003 contributor: fullname: Khalifa M – volume: 19 start-page: 43 issue: 1 year: 2010 ident: ref15 article-title: Prevalence of community-acquired and nosocomial infections in hospitalized patients with systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203309345776 contributor: fullname: Navarro-Zarza JE – year: 2007 publication-title: Reumatologia: princípios e prática contributor: fullname: Skare, TL – volume: 40 issue: 9 year: 1997 article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 16 start-page: 309 issue: 5 year: 2007 end-page: 317 article-title: Current causes of death in systemic lupus erythematosus in Europe, 2000--2004: relation to disease activity and damage accrual publication-title: Lupus – volume: 14 start-page: 1005 issue: 11 year: 2015 end-page: 1018 article-title: Genetics and novel aspects of therapies in systemic lupus erythematosus publication-title: Autoimmun Rev – volume: 37 start-page: 792 issue: 12 year: 2007 end-page: 795 article-title: Infections in systemic lupus erythematosus publication-title: Med Mal Infect – volume: 17 start-page: 281 issue: 4 year: 2008 end-page: 288 article-title: Previous antimalarial therapy in patients diagnosed with lupus nephritis: influence on outcomes and survival publication-title: Lupus – volume: 35 start-page: 75 issue: 1 year: 2009 end-page: 93 article-title: Pathophysiology and clinical spectrum of infections in systemic lupus erythematosus publication-title: Rheum Dis Clin North Am – volume: 11 start-page: 234 issue: 4 year: 2002 end-page: 239 article-title: The nature and outcome of infection in systemic lupus erythematosus publication-title: Lupus – volume: 19 start-page: 43 issue: 1 year: 2010 end-page: 48 article-title: Prevalence of community-acquired and nosocomial infections in hospitalized patients with systemic lupus erythematosus publication-title: Lupus – volume: 10 start-page: 154 issue: 3 year: 2001 end-page: 161 article-title: Cyclophosphamide for the treatment of systemic lupus erythematosus publication-title: Lupus – volume: 22 start-page: 697 issue: 7 year: 2013 end-page: 701 article-title: Predictors of corticosteroid tapering in SLE patients: the Hopkins Lupus Cohort publication-title: Lupus – volume: 13 start-page: 366 issue: 5 year: 2004 end-page: 371 article-title: Cyclophosphamide: new approaches for systemic lupus erythematosus publication-title: Lupus – volume: 14 start-page: s9 year: 2005 end-page: 11 article-title: Mycophenolate mofetil and systemic lupus erythematosus: an overview publication-title: Lupus – volume: 16 start-page: 119 issue: 3 year: 2010 end-page: 122 article-title: Incidence, risk factors, and outcome of Herpes zoster in systemic lupus erythematosus publication-title: J Clin Rheumatol – volume: 41 start-page: 268 issue: 4 year: 2009 end-page: 274 article-title: Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus publication-title: Scand J Infect Dis – volume: 35 start-page: 486 issue: 4 year: 2013 end-page: 497 article-title: Cumulative burden of oral corticosteroid adverse effects and the economic implications of corticosteroid use in patients whit systemic lupus erythematosus publication-title: Clin Ther – volume: 17 start-page: 1117 issue: 12 year: 2008 end-page: 1121 article-title: Recurrent urinary tract infections and bladder dysfunction in systemic lupus erythematosus publication-title: Lupus – volume: 22 start-page: 238 issue: 3 year: 2013 end-page: 244 article-title: Increased incidence of herpes zoster among patients with systemic lupus erythematosus publication-title: Lupus – volume: 11 issue: 4 year: 2009 article-title: Predictors of major infections in systemic lupus erythematosus publication-title: Arthritis Res Ther – volume: 60 start-page: 221 issue: 2 year: 1976 end-page: 225 article-title: The bimodal mortality pattern of systemic lupus erythematosus publication-title: Am J Med – volume: 22 start-page: 1286 issue: 12 year: 2013 end-page: 1294 article-title: Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies publication-title: Lupus – volume: 10 start-page: 140 issue: 3 year: 2001 end-page: 147 article-title: Treatment of lupus with corticosteroids publication-title: Lupus – volume: 19 start-page: 1419 issue: 12 year: 2010 end-page: 1424 article-title: Infections in systemic lupus erythematosus publication-title: Lupus – volume: 23 start-page: 1512 issue: 14 year: 2014 end-page: 1516 article-title: Serious infections in systemic lupus erythematosus with a focus on pneumococcal infections publication-title: Lupus – volume: 21 start-page: 1300 issue: 12 year: 2015 end-page: 1307 article-title: Lupus cystitis in Korean patients with systemic lupus erythematosus: risk factors and clinical outcomes publication-title: Lupus – volume: 15 start-page: 584 issue: 9 year: 2006 end-page: 589 article-title: Infections in systemic lupus erythematosus: a prospective and controlled study of 110 patients publication-title: Lupus |
| SSID | ssj0061689 |
| Score | 2.1044257 |
| Snippet | To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original... ABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections... |
| SourceID | doaj scielo pubmedcentral crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 47 |
| SubjectTerms | Adolescent Adult Aged Anti-Inflammatory Agents - therapeutic use Antirheumatic Agents - therapeutic use Brazil - epidemiology Cyclophosphamide - therapeutic use Female Follow-Up Studies Hospitals, University - statistics & numerical data Humans Imunossupressão Incidence Infecções urinárias/etiologia Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - epidemiology Lúpus eritematoso sistêmico/complicações Male MEDICINE, GENERAL & INTERNAL Middle Aged Original Photosensitivity Disorders - complications Prednisone - therapeutic use Respiratory Tract Infections - drug therapy Respiratory Tract Infections - etiology Retrospective Studies Urinary Tract Infections - drug therapy Urinary Tract Infections - etiology Young Adult |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07T8MwELagQogF8aa8lAGJyapjx3Y6FmjVBRgKEltkO7ZAQgGRZuDfcxeHqmVhYcxDzuU7O_ddbH9HyCULwkFcYNQPjaeoV0JtLiUFpm1dMJkOJe53ns70_XN-O0aZnEWpL1wTFuWBI3ADpkruFQuQS_ksZLkts6BNyoK2abB5THyY-kmm4jdYpaotfgfkRVPoYbLbNCeHbDDDiQewqo19avQgMvweLwWlVrt_KSD9Xiy5gbHpbTkMTXbIdscfk1G0e5es-WqPbN51M-T7BAZ8XF1V1YmpyiQqNb-65K35aOrEf35Fmdb3uqkPyNNk_HgzpV1BBOpkKuY0U0F7yYEUq6BkCgdGAz0QnjvrvdNs6BxubeVYFt0LbrkwZcit46mR1hlxSHrVe-WPSYIzrsYGB7jKrAQwrCqB_EiXy8BSn_UJ_UGk-Ii6FwXmC4Bg0SJYrCLYJ9cI2-JeVK1uT4Avi86XxV--7JOjiPWiGa4xdxdgjl7xwspzVq9Ury-tSjZkYhxy0T65iv4qusFZ_7IfWS4yW33yH69wSraw0fiT5oz05p-NPyfrddlctD30G9Y05RI priority: 102 providerName: Directory of Open Access Journals |
| Title | Infections and systemic lupus erythematosus |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27074234 https://pubmed.ncbi.nlm.nih.gov/PMC4872917 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082016000100047&lng=en&tlng=en https://doaj.org/article/06d2e60f133e4f48bd4f7a10f7b1fb81 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB51UVVxQfQBTWlXOVTqKazfzh4pD4EQbSVaqbfIdmy60pJdbciBf18_khXhyC1xItuasTPfxDPfAHxFjhpvF1Bh58oWga-k0CXnhUfa2jjFpKtDvvPlrfzxtzw7DzQ5fMiFiUH7Ri-Om-X9cbP4F2Mr1_dmNsSJzX7dnHqQTbybMZvAxF8MLnr6_AosYt27cLzgx0Zlny_H52h2u230Zk-c_KRsHirBERkcRMpGpiky-D8xS89DJl8HC7V8aowu9mGvR5H5SZrtW3hlm3fw5qY_J38PftunGKumzVVT54mveWHyZbfu2txuHhNZ66rt2g_w5-L89-ll0ZdFKAzH9KFgwknLiYfGwgmO_Y2SHiRQS4y21kg0NyYkuJJQHN1SoglVtSu1IVhxbRQ9gJ1m1diPkIdzV6WdcZhyVnu5aFF7CMRNyR3ClmVQDBKp1on9ogpegxdmFYVZjYWZwfcgtu27gbs6Nqw2d1WvwQqJmliB_JjUMsdKXTMnFUZOaux0iTM4TLLedjMoKAM50sJonPETv3QiV3a_VDL4lvRV9Vu0fTb_gHUDvpWfXjzGEeyGntL_mc-w87Dp7BeYtHU39Vj96noa_f1pXK3_ATUn5yQ |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4VqNpeoKWvAG1zQOoprN_OHnlqq7IUCSpxi2zHbldasqsNOfTf146TFeHIMXbkSeaLPd_EM2OAQ-So8XYBZXasbBbqlWQ65zzzTFsbp5h0Zch3ntzIq7v87DyUyeF9LkwbtG_07Kia3x9Vs79tbOXy3oz6OLHR9fTUk2zi3YzRBmz5-YpQ76THBVhg0Z58FzYYvHSUdxlzfIxGN-tGb_jE8S_KxuEsOCKDi0jZwDi1NfwfGaanQZMvg42aPzZHFzvPfJG3sN3xz_Q4dr-DF7bahVfTbof9PfgFI0ZnVXWqqjKNlZ5nJp03y6ZO7epfLPO6qJv6A_y-OL89nWTdgQqZ4Zg-ZEw4aTnxpFo4wbG_UNLTC2qJ0dYaicbGhNRYEo5Vt5RoQlXpcm0IVlwbRT_CZrWo7GdIw46t0s44TDkrvT61KD154ibnDmHLEsh6TRbLWDejCP6GB6FoQSiGICRwEtS9vjdUvW4bFqs_RaeyAomSWIG8TGqZY7kumZMKIyc1djrHCXyKGK2H6YFNQA7QG8gZ9nis2irbHTYJfI84F93krp88f2DJgRnLvWfL-AavJ7fTy-Lyx9XPfXgTRo1_eQ5g82HV2C-wUZfN1_Yr_w_BxPrE |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB4VWiEupU9InzlU6inEb2ePFFhRtVAkWqm3yM-y0pJdbcih_752nF0RjvQYx7KT-WLP53j8DcAn5KkJfgEVbqJcEfVKCl1xXgSmrY1XTHobzzufXcmL39XJaZTJ2aT66oP2jZ4dNvObw2Z23cdWLm9MuY4TKy_PjwPJJmGZUS6tL7fgcRiziKwX6mkSFlj02e_iJkN4AlQNp-b4BJVXm8Lg_MTRD8omMR8ckXGZSNnIQfU6_nec0_3AySfRT83vuqTp3n-8zDN4OvDQ_ChVeQ6PXPMCds6HnfaXECaOFKXVtLlqbJ4Un2cmn3fLrs3d6m-Se120XfsKfk1Pfx6fFUNihcJwTG8LJrx0nARyLbzgOFwoGWgGdcRo54xEE2PiEVkS06s7SjShyvpKG4IV10bR17DdLBp3AHncuVXaG48pZzbYVAsbSBQ3FfcIO5ZBsbZmvUz6GXVcdwQg6h6IegxEBl-iyTd1o_p1X7BY_akHs9VIWOIECn1SxzyrtGVeKoy81NjrCmewn3DaNLMGNwM5QnDUz_hOwKtX2x7wyeBzwroeBnl77_kjW44MWb55cB8fYefyZFp__3rx7S3sxkbTz553sH276tx72Gpt96H_0P8B3I_9RA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Infections+and+systemic+lupus+erythematosus&rft.jtitle=Einstein+%28Sa%CC%83o+Paulo%2C+Brazil%29&rft.au=Skare%2C+Thelma+Larocca&rft.au=Dagostini%2C+J%C3%A9ssica+Scherer&rft.au=Zanardi%2C+Patricia+Imai&rft.au=Nisihara%2C+Renato+Mitsunori&rft.date=2016-01-01&rft.pub=Instituto+Israelita+de+Ensino+e+Pesquisa+Albert+Einstein&rft.issn=1679-4508&rft.eissn=2317-6385&rft.volume=14&rft.issue=1&rft.spage=47&rft.epage=51&rft_id=info:doi/10.1590%2FS1679-45082016AO3490&rft_id=info%3Apmid%2F27074234&rft.externalDBID=PMC4872917 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1679-4508&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1679-4508&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1679-4508&client=summon |