Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such...

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Bibliographic Details
Published in:	Annals of oncology Vol. 19; no. 5; pp. 915 - 919
Main Authors:	Soong, R., Shah, N., Salto-Tellez, M., Tai, B. C., Soo, R. A., Han, H. C., Ng, S. S., Tan, W. L., Zeps, N., Joseph, D., Diasio, R. B., Iacopetta, B.
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-05-2008 Oxford Publishing Limited (England)
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - enzymology Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy, Adjuvant colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Dihydrouracil Dehydrogenase (NADP) - analysis Drug Resistance, Neoplasm Female fluorouracil Fluorouracil - administration & dosage Fluorouracil - pharmacokinetics Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Leucovorin - administration & dosage Male Medical sciences Middle Aged Neoplasm Proteins - analysis Neoplasm Staging Pharmacology. Drug treatments predictive Prognosis prognostic Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Thymidine Phosphorylase - analysis thymidylate synthase Thymidylate Synthase - analysis Tumors prognostic predictive thymidylate synthase colorectal cancer fluorouracil Antineoplastic agent Rectal disease Prognosis Angiogenic factor Glycosyltransferases Colorectal cancer Intestinal disease Thymidine phosphorylase Fluorouracil Human Enzyme Fluoropyrimidine derivatives Transferases Enzyme inhibitor ) Malignant tumor Dihydropyrimidine dehydrogenase (NADP Gene expression Thymidylate synthase Protein Colonic disease Chemotherapy Treatment Antimetabolic Methyltransferases Pyrimidine derivatives Digestive diseases Oxidoreductases Pentosyltransferases Cancer
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