Molecularly imprinted poly(acrylonitrile-co-acrylic acid) matrix with sclareol

• Published in: Polymer engineering and science Vol. 54; no. 7; pp. 1484 - 1494
• Main Authors: Dima, Stefan-Ovidiu, Dobre, Tanase, Chetraru, Olga, Nicolae, Cristian-Andi, Spataru, Catalin-Ilie, Sarbu, Andrei
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 01-07-2014; Wiley; Society of Plastics Engineers, Inc
• Subjects: Analysis; Applied sciences; Biological and medical sciences; Chemical properties; Exact sciences and technology; General pharmacology; Materials research; Medical sciences; Organic polymers; Pharmacology. Drug treatments; Physicochemistry of polymers; Polyacrylonitrile; Polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; Production processes; Rheology; Romania; Antineoplastic agent; Acrylic acid copolymer; Property composition relationship; Phase reversal; Experimental study; Polyelectrolyte; Acrylonitrile copolymer; Binding capacity; Labiatae; Template polymerization; Dicotyledones; Morphology; Preparation; Angiospermae; Plant origin; Diterpene; Spermatophyta; Radical copolymerization; Labdane derivatives; Salvia; Molecular imprinting
• ISSN: 0032-3888; 1548-2634
• DOI: 10.1002/pen.23689

There are presented results regarding a new set of molecularly imprinted polymers (MIPs) based on acrylonitrile:acrylic acid (AN:AA) copolymer matrix. As template, it was used sclareol, an important anticancer bioactive compound, never used before for molecular imprinting. An emerging and insufficient studied MIP preparation method, namely the phase inversion, was used to prepare 0.8 mm spherical sclareol MIPs (S‐MIPs). Three AN:AA copolymers, having the initial monomer ratios 90:10, 80:20, and 70:30, were synthesized by radical copolymerization in emulsion, without emulsifier. After that, each copolymer was dissolved in the presence of the template (sclareol) in dimethylformamide. The imprinting and the morphology of these new materials were analyzed by rheology, elemental analysis, infrared spectroscopy, size exclusion chromatography, thermogravimetric analysis, differential scanning calorimetry, batch rebinding tests, and Scatchard analysis. The conclusion was that the AN:AA‐80:20 matrix proved to be the optimized solution between high rigidity (given by the AN segments) and high affinity for the template (given by AA segments), the average imprinting factor for this system being 2.67. POLYM. ENG. SCI., 54:1484–1494, 2014. © 2013 Society of Plastics Engineers