Hydrogen peroxide overproduced in breast cancer cells can serve as an anticancer prodrug generating apoptosis-stimulating hydroxyl radicals under the effect of tamoxifen-ferrocene conjugate

A new approach to the treatment of cancer is suggested, based on the innate overproduction of hydrogen peroxide in cancer cells. Hydrogen peroxide serves as a prodrug in the presence of transition metal ions, such as iron delivered by ferrocene. Under the effect of ferrocene, hydrogen peroxide is sp...

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Bibliographic Details
Published in:	Journal of pharmacy and pharmacology Vol. 59; no. 11; pp. 1549 - 1553
Main Authors:	Wlassoff, Wjatschesslaw A., Albright, Craig D., Sivashinski, Michael S., Ivanova, Anastasia, Appelbaum, Jacob G., Salganik, Rudolph I.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-11-2007
Subjects:	Antineoplastic Agents, Hormonal - chemistry Antineoplastic Agents, Hormonal - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - metabolism DNA Damage - drug effects Drug Delivery Systems Female Ferrous Compounds - chemistry Ferrous Compounds - pharmacology Humans Hydrogen Peroxide - metabolism Hydroxyl Radical - metabolism Metallocenes Prodrugs Reactive Oxygen Species - metabolism Receptors, Estrogen - metabolism Tamoxifen - chemistry Tamoxifen - pharmacology Tumor Cells, Cultured
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