Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease

Objectives In patients with coronary artery disease (CAD) medically managed according to currently accepted guidelines, we tested whether a 1-month dietary intervention with flavanol-containing cocoa leads to an improvement of endothelial dysfunction and whether this is associated with an enhanced n...

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Bibliographic Details
Published in:	Journal of the American College of Cardiology Vol. 56; no. 3; pp. 218 - 224
Main Authors:	Heiss, Christian, MD, DrMed, Jahn, Sarah, MB, Taylor, Melanie, BS, Real, Wendy May, BS, Angeli, Franca S., MD, Wong, Maelene L., BS, Amabile, Nicolas, MD, Prasad, Megha, BA, Rassaf, Tienush, MD, DrMed, Ottaviani, Javier I., PhD, Mihardja, Shirley, PhD, Keen, Carl L., PhD, Springer, Matthew L., PhD, Boyle, Andrew, MBBS, PhD, Grossman, William, MD, Glantz, Stanton A., PhD, Schroeter, Hagen, PhD, Yeghiazarians, Yerem, MD
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 13-07-2010 Elsevier Elsevier Limited
Subjects:	angiogenic cells Bioavailability Biological and medical sciences Blood Pressure Cacao Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cholesterol coronary artery disease Coronary Disease - diet therapy Coronary Disease - physiopathology Coronary heart disease Diet Diseases of the digestive system Double-Blind Method Drug therapy Endothelial Cells - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzymes Female flavanols Flavonoids - administration & dosage Flavonoids - pharmacology Flow velocity flow-mediated vasodilation Heart Heart rate Humans Internal Medicine Intervention Lipoproteins Male Medical sciences Middle Aged Mortality Neovascularization, Physiologic - physiology nutrition Plasma Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Statins Studies Variance analysis Vascular endothelial growth factor Vasodilation - physiology coronary artery disease NO LoFI HiFI flow-mediated vasodilation angiogenic cells SDF high-flavanol intervention LDL FMD nitric oxide stem cell factor CAC VEGF CAD flavanols stromal cell-derived factor low-density lipoprotein circulating angiogenic cell brachial artery nutrition vascular endothelial growth factor low-flavanol intervention SCF flow-mediated dilation BA Human Mobilization Improvement Diet therapy Diet Cardiovascular disease Patient Circulatory system Endothelial function Cardiology Coronary heart disease Cell
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