Fragment-based drug nanoaggregation reveals drivers of self-assembly

Drug nanoaggregates are particles that can deleteriously cause false positive results during drug screening efforts, but alternatively, they may be used to improve pharmacokinetics when developed for drug delivery purposes. The structural features of molecules that drive nanoaggregate formation rema...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; p. 8340
Main Authors:	Chen, Chen, Wu, You, Wang, Shih-Ting, Berisha, Naxhije, Manzari, Mandana T., Vogt, Kristen, Gang, Oleg, Heller, Daniel A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14-12-2023 Nature Publishing Group Nature Portfolio
Subjects:	639/301/357/341 639/925/357/354 Core-shell structure Drug delivery Drug development Drug screening Fragments Humanities and Social Sciences Hydrogen Hydrogen bonding Hydrogen bonds Intracellular multidisciplinary NANOSCIENCE AND NANOTECHNOLOGY Pharmacokinetics Science Science (multidisciplinary) Self-assembly
Online Access:	Get full text
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