Rasburicase in hemolytic uremic syndrome related to Shiga toxin-producing Escherichia coli: a report of nine cases

• Published in: Pediatric nephrology (Berlin, West) Vol. 35; no. 6; pp. 1133 - 1137
• Main Authors: Balestracci, Alejandro, Meni Battaglia, Luciana, Martin, Sandra Mariel, Toledo, Ismael
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2020; Springer; Springer Nature B.V
• Subjects: Brief Report; Care and treatment; Case reports; Case studies; Child, Preschool; Children; Creatinine; Diagnosis; Dialysis; Dialysis - adverse effects; E coli; Escherichia coli; Escherichia coli infections; Escherichia coli Infections - complications; Escherichia coli Infections - drug therapy; Female; Hemolytic uremic syndrome; Hemolytic-Uremic Syndrome - etiology; Humans; Hyperuricemia; Male; Medicine; Medicine & Public Health; Nephrology; Pediatrics; Rasburicase; Renal function; Shiga toxin; Shiga-Toxigenic Escherichia coli - isolation & purification; Testing; Urate Oxidase - administration & dosage; Uric acid; Uric Acid - blood; Urology; Argentina; Hemolytic uremic syndrome; Hyperuricemia; Rasburicase; Escherichia coli
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-020-04528-0

Background
Hyperuricemia might induce additional renal damage in children with hemolytic uremic syndrome related to Shiga toxin-producing
Escherichia coli
(STEC-HUS). A few case reports have shown rasburicase to be effective in decreasing serum uric acid (UA) and improving renal function. However, there is only one report on the use of rasburicase in a child with STEC-HUS, which shows satisfactory results. We describe here the safety and efficacy of rasburicase in nine additional cases.
Case-diagnosis/treatment
Data from 9 children (5 females, median age 2 years) who received rasburicase were reviewed. At admission, 6 were dehydrated and 3 euvolemic. Dehydrated patients received saline solution and afterwards, as well as for those initially euvolemic, we aimed to keep a neutral fluid balance. Despite this, urine output did not increase. Baseline creatinine was 3.35 mg/dL (1.47–9.1) and UA 11.4 mg/dL (8.3–19.2). A single dose of rasburicase (0.2 mg/kg) was given 6–8 h after admission, which reduced UA levels to 1.8 mg/dL (0.3–5,
p
 = 0.009) on the next day. However, renal parameters worsen and dialysis had to be initiated. Then, while still on dialysis, a UA rebound occurred in all cases reaching a peak of 8.9 mg/dL (4.5–13.8). Just after a steady increase in urine output, a sustained decline in UA levels concomitantly occurred with an improvement in renal function. At discharge, all patients reached normal UA levels. No side effects were recorded.
Conclusions
Administration of rasburicase in children with STEC-HUS was safe but failed to provide any significant benefit despite fall in serum UA levels.