Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion

Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely attempted through the use of enzymatic reagents. Ocriplasmin has been the only FDA-approved clinical reagent so far. Several adverse effects of ocriplasmin have emerged, however, and the search for alterna...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 8250
Main Authors:	Santra, Mithun, Sharma, Maryada, Katoch, Deeksha, Jain, Sahil, Saikia, Uma Nahar, Dogra, Mangat R., Luthra-Guptasarma, Manni
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19-05-2020 Nature Publishing Group
Subjects:	631/80/79/1236 692/308/153 692/308/2778 Adhesion Animals Collagen Collagen - administration & dosage Collagen - chemistry Collagen - genetics Collagen - metabolism Dehiscence Humanities and Social Sciences Humans Integrins - genetics Integrins - metabolism Intravitreal Injections Liquefaction multidisciplinary Peptides Peptides - administration & dosage Protein Domains Rabbits Reagents Retina Retina - drug effects Retina - metabolism RGD-containing peptides Science Science (multidisciplinary) Vitrectomy Vitreous Body - drug effects Vitreous Body - metabolism Vitreous Detachment - drug therapy Vitreous Detachment - genetics Vitreous Detachment - metabolism Vitreous Detachment - surgery
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