Increased Production of Tumor Necrosis Factor-alpha by Glial Cells Exposed to Simulated Ischemia or Elevated Hydrostatic Pressure Induces Apoptosis in Cocultured Retinal Ganglion Cells

Although glial cells in the optic nerve head undergo a reactivation process in glaucoma, the role of glial cells during glaucomatous neurodegeneration of retinal ganglion cells is unknown. Using a coculture system in which retinal ganglion cells and glial cells are grown on different layers but shar...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 20; no. 23; pp. 8693 - 8700
Main Authors:	Tezel, Gulgun, Wax, Martin B
Format:	Journal Article
Language:	English
Published:	United States Soc Neuroscience 01-12-2000 Society for Neuroscience
Subjects:	Animals Apoptosis Blotting, Western Caspases - metabolism Cell Survival - drug effects Cells, Cultured Coculture Techniques Culture Media, Conditioned - metabolism Flow Cytometry Fluorescent Dyes Glaucoma - etiology Hydrostatic Pressure In Situ Nick-End Labeling Ischemia - metabolism Neuroglia - cytology Neuroglia - metabolism Neuroglia - secretion Nitric Oxide - metabolism Nitric Oxide - pharmacology Nitric Oxide - secretion Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Rats Retinal Ganglion Cells - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Stilbamidines Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - secretion
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