Hypercapnia Alters Alveolar Epithelial Repair by a pH-Dependent and Adenylate Cyclase-Mediated Mechanism

Lung cell injury and repair is a hallmark of the acute respiratory distress syndrome (ARDS). Lung protective mechanical ventilation strategies in these patients may lead to hypercapnia (HC). Although HC has been explored in the clinical context of ARDS, its effect upon alveolar epithelial cell (AEC)...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 349
Main Authors:	Cortes-Puentes, Gustavo A., Westerly, Blair, Schiavo, Dante, Wang, Shaohua, Stroetz, Randolph, Walters, Bruce, Hubmayr, Rolf D., Oeckler, Richard A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-01-2019 Nature Publishing Group
Subjects:	13 13/106 14/105 631/443/1784 692/420/256/2516 692/699/1785/3193 96/106 96/63 Adenylate cyclase Alveoli Carbon dioxide Cell injury Cyclic AMP Epithelial cells Forskolin Humanities and Social Sciences Hypercapnia Intracellular Kinases Mechanical ventilation multidisciplinary Penicillin pH effects Proteins Respiratory distress syndrome Science Science (multidisciplinary) Sensors Sodium bicarbonate Ventilators Wound healing Wounding
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