Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis

Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria are a key element in energy homeostasis, the development of obesity has been strongly associated with mitochondrial imbalance. Polyphenols are...

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Published in:	International journal of molecular sciences Vol. 19; no. 9; p. 2757
Main Authors:	Wood Dos Santos, Tanila, Cristina Pereira, Quélita, Teixeira, Lucimara, Gambero, Alessandra, A Villena, Josep, Lima Ribeiro, Marcelo
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 13-09-2018 MDPI
Subjects:	Animals Antioxidants Apoptosis Appetite Biosynthesis Diabetes Diet Dopamine Energy balance Energy expenditure Energy management Food Free radicals Homeostasis Humans Immunity, Innate Kinases Lipids Metabolism Microarray Analysis Mitochondria Mitochondria - drug effects Mitochondria - metabolism mitochondrial biogenesis Mitochondrial DNA Obesity Organelle Biogenesis Phosphorylation Polyphenols Polyphenols - pharmacology Reactive Oxygen Species - metabolism Review Rodents Thermogenesis Thermogenesis - drug effects Weight control Brazil polyphenols mitochondrial biogenesis thermogenesis
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Abstract	Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria are a key element in energy homeostasis, the development of obesity has been strongly associated with mitochondrial imbalance. Polyphenols are the largest group of phytochemicals, widely distributed in the plant kingdom, abundant in fruits and vegetables, and have been classically described as antioxidants owing to their well-established ability to eliminate free radicals and reactive oxygen species (ROS). During the last decade, however, growing evidence reports the ability of polyphenols to perform several important biological activities in addition to their antioxidant activity. Special attention has been given to the ability of polyphenols to modulate mitochondrial processes. Thus, some polyphenols are now recognized as molecules capable of modulating pathways that regulate mitochondrial biogenesis, ATP synthesis, and thermogenesis, among others. The present review reports the main benefits of polyphenols in modulating mitochondrial processes that favor the regulation of energy expenditure and offer benefits in the management of obesity, especially thermogenesis and mitochondrial biogenesis.
AbstractList	Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria are a key element in energy homeostasis, the development of obesity has been strongly associated with mitochondrial imbalance. Polyphenols are the largest group of phytochemicals, widely distributed in the plant kingdom, abundant in fruits and vegetables, and have been classically described as antioxidants owing to their well-established ability to eliminate free radicals and reactive oxygen species (ROS). During the last decade, however, growing evidence reports the ability of polyphenols to perform several important biological activities in addition to their antioxidant activity. Special attention has been given to the ability of polyphenols to modulate mitochondrial processes. Thus, some polyphenols are now recognized as molecules capable of modulating pathways that regulate mitochondrial biogenesis, ATP synthesis, and thermogenesis, among others. The present review reports the main benefits of polyphenols in modulating mitochondrial processes that favor the regulation of energy expenditure and offer benefits in the management of obesity, especially thermogenesis and mitochondrial biogenesis.
Author	Cristina Pereira, Quélita Lima Ribeiro, Marcelo Wood Dos Santos, Tanila Teixeira, Lucimara A Villena, Josep Gambero, Alessandra
AuthorAffiliation	2 Programa de Pos Graduação em Genetica e Biologia Molecular, State University of Campinas, Campinas, São Paulo 13083-881, Brazil 3 Laboratory of Metabolism and Obesity, Vall d’Hebron-Institut de Recerca, 08035 Barcelona, Spain; josep.villena@vhir.org 1 Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil; quelitapereirapa@gmail.com (Q.C.P.); lucimara.teixeira@usf.edu.br (L.T.); alessandra.gambero@usf.edu.br (A.G.)
AuthorAffiliation_xml	– name: 3 Laboratory of Metabolism and Obesity, Vall d’Hebron-Institut de Recerca, 08035 Barcelona, Spain; josep.villena@vhir.org – name: 2 Programa de Pos Graduação em Genetica e Biologia Molecular, State University of Campinas, Campinas, São Paulo 13083-881, Brazil – name: 1 Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil; quelitapereirapa@gmail.com (Q.C.P.); lucimara.teixeira@usf.edu.br (L.T.); alessandra.gambero@usf.edu.br (A.G.)
Author_xml	– sequence: 1 givenname: Tanila surname: Wood Dos Santos fullname: Wood Dos Santos, Tanila email: tanilawood@gmail.com, tanilawood@gmail.com organization: Programa de Pos Graduação em Genetica e Biologia Molecular, State University of Campinas, Campinas, São Paulo 13083-881, Brazil. tanilawood@gmail.com – sequence: 2 givenname: Quélita surname: Cristina Pereira fullname: Cristina Pereira, Quélita email: quelitapereirapa@gmail.com organization: Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil. quelitapereirapa@gmail.com – sequence: 3 givenname: Lucimara surname: Teixeira fullname: Teixeira, Lucimara email: lucimara.teixeira@usf.edu.br organization: Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil. lucimara.teixeira@usf.edu.br – sequence: 4 givenname: Alessandra surname: Gambero fullname: Gambero, Alessandra email: alessandra.gambero@usf.edu.br organization: Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil. alessandra.gambero@usf.edu.br – sequence: 5 givenname: Josep surname: A Villena fullname: A Villena, Josep email: josep.villena@vhir.org organization: Laboratory of Metabolism and Obesity, Vall d'Hebron-Institut de Recerca, 08035 Barcelona, Spain. josep.villena@vhir.org – sequence: 6 givenname: Marcelo orcidid: 0000-0003-4529-7832 surname: Lima Ribeiro fullname: Lima Ribeiro, Marcelo email: ribeiroml@hotmail.com organization: Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil. ribeiroml@hotmail.com
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Copyright	2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 by the authors. 2018
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Keywords	polyphenols mitochondrial biogenesis thermogenesis
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Snippet	Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria...
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SubjectTerms	Animals Antioxidants Apoptosis Appetite Biosynthesis Diabetes Diet Dopamine Energy balance Energy expenditure Energy management Food Free radicals Homeostasis Humans Immunity, Innate Kinases Lipids Metabolism Microarray Analysis Mitochondria Mitochondria - drug effects Mitochondria - metabolism mitochondrial biogenesis Mitochondrial DNA Obesity Organelle Biogenesis Phosphorylation Polyphenols Polyphenols - pharmacology Reactive Oxygen Species - metabolism Review Rodents Thermogenesis Thermogenesis - drug effects Weight control
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Title	Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis
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