Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci
Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open...
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Published in: | The Journal of experimental medicine Vol. 174; no. 5; pp. 1255 - 1258 |
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Main Authors: | , , , , , |
Format: | Journal Article |
Language: | English |
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New York, NY
Rockefeller University Press
01-11-1991
The Rockefeller University Press |
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Abstract | Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superantigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17+ T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell. |
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AbstractList | Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superartigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17 super(+) T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell. Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superantigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17+ T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell. |
Author | BLACKMAN, M. A LUND, F. E PALMER, E WOODLAND, D. L HAPP, M. P CORLEY, R. B |
Author_xml | – sequence: 1 givenname: D. L surname: WOODLAND fullname: WOODLAND, D. L organization: Saint Jude children's res. hosp., dep. immunology, Memphis TN 38105, United States – sequence: 2 givenname: F. E surname: LUND fullname: LUND, F. E organization: Saint Jude children's res. hosp., dep. immunology, Memphis TN 38105, United States – sequence: 3 givenname: M. P surname: HAPP fullname: HAPP, M. P organization: Saint Jude children's res. hosp., dep. immunology, Memphis TN 38105, United States – sequence: 4 givenname: M. A surname: BLACKMAN fullname: BLACKMAN, M. A organization: Saint Jude children's res. hosp., dep. immunology, Memphis TN 38105, United States – sequence: 5 givenname: E surname: PALMER fullname: PALMER, E organization: Saint Jude children's res. hosp., dep. immunology, Memphis TN 38105, United States – sequence: 6 givenname: R. B surname: CORLEY fullname: CORLEY, R. B organization: Saint Jude children's res. hosp., dep. immunology, Memphis TN 38105, United States |
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Keywords | Cell culture Oncovirinae T cell receptor Variable region Beta-Peptide chain Elimination Retroviridae Hybridoma Gene expression Provirus Virus Endogenous Gene T-Lymphocyte Type B oncovirus LTR sequence Mouse mammary tumor virus Clone Specific relation |
Language | English |
License | CC BY 4.0 This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
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Snippet | Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when... |
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SubjectTerms | Animals Antigens - analysis Biological and medical sciences Chromosome Mapping Fundamental and applied biological sciences. Psychology Gammaretrovirus - genetics Mice Mice, Inbred BALB C Microbiology Open Reading Frames Proviruses - genetics Receptors, Antigen, T-Cell - analysis Repetitive Sequences, Nucleic Acid Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T-Lymphocytes - immunology Transfection Virology |
Title | Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci |
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