Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci

Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open...

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Published in:The Journal of experimental medicine Vol. 174; no. 5; pp. 1255 - 1258
Main Authors: WOODLAND, D. L, LUND, F. E, HAPP, M. P, BLACKMAN, M. A, PALMER, E, CORLEY, R. B
Format: Journal Article
Language:English
Published: New York, NY Rockefeller University Press 01-11-1991
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Abstract Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superantigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17+ T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell.
AbstractList Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superartigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17 super(+) T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell.
Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superantigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17+ T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell.
Author BLACKMAN, M. A
LUND, F. E
PALMER, E
WOODLAND, D. L
HAPP, M. P
CORLEY, R. B
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Issue 5
Keywords Cell culture
Oncovirinae
T cell receptor
Variable region
Beta-Peptide chain
Elimination
Retroviridae
Hybridoma
Gene expression
Provirus
Virus
Endogenous
Gene
T-Lymphocyte
Type B oncovirus
LTR sequence
Mouse mammary tumor virus
Clone
Specific relation
Language English
License CC BY 4.0
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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Snippet Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when...
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StartPage 1255
SubjectTerms Animals
Antigens - analysis
Biological and medical sciences
Chromosome Mapping
Fundamental and applied biological sciences. Psychology
Gammaretrovirus - genetics
Mice
Mice, Inbred BALB C
Microbiology
Open Reading Frames
Proviruses - genetics
Receptors, Antigen, T-Cell - analysis
Repetitive Sequences, Nucleic Acid
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
T-Lymphocytes - immunology
Transfection
Virology
Title Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci
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Volume 174
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