Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury

Highlights • Fenbendazole improved pathological and functional outcomes following SCI in mice. • Fenbendazole disrupts microtubules and can impair B cell proliferation. • Fenbendazole reduced B cells and IgG at the spinal lesion site. • Fenbendazole and related compounds represent novel potential th...

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Bibliographic Details
Published in:	Neuroscience Vol. 256; pp. 163 - 169
Main Authors:	Yu, C.G, Singh, R, Crowdus, C, Raza, K, Kincer, J, Geddes, J.W
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier 03-01-2014
Subjects:	Analysis of Variance Animals Biological and medical sciences Disease Models, Animal Drug Administration Schedule Female Fenbendazole - therapeutic use Fundamental and applied biological sciences. Psychology Immunoglobulin G - metabolism Leukocyte Common Antigens - metabolism Mice Mice, Inbred C57BL Neurology Recovery of Function - drug effects Recovery of Function - physiology Spinal Cord - pathology Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Time Factors Trauma Severity Indices Vertebrates: nervous system and sense organs spinal cord injury basso mouse scale GLI locomotor function regions of interest BMS traumatic injury gray-level-index eriochrome cyanine ROI pathogenic autoantibody SCI EC Fenbendazole Spinal cord Functional recovery Central nervous system Lesion Trauma
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Summary:	Highlights • Fenbendazole improved pathological and functional outcomes following SCI in mice. • Fenbendazole disrupts microtubules and can impair B cell proliferation. • Fenbendazole reduced B cells and IgG at the spinal lesion site. • Fenbendazole and related compounds represent novel potential therapeutics for SCI.
Bibliography:	Contact information for other authors Kashif Raza, Technician Seniot, Phone: 859-323-5041, FAX: 859-257-5737, rkashif79@hotmail.com Jeanie Kincer: DVM, DACLAM, DLAR Assistant Director, Phone: 859-323-5469 jfkinc2@email.uky.edu James W. Geddes, Ph.D., Professor, Director, Spinal Cord and Brain Injury Research Center, B481, BBSRB, 741 S. Limestone Street, Lexington, KY 40536-0509, USA, Phone: 859-323-5176, jgeddes@uky.edu Carolyn Crowdus, Ph.D. candidate, Phone: 859-323-5176, FAX: 859-257-5737, cacrow3@uky.edu Ranjana Singh: Ph.D. candidate, Phone: 859-323-5176, FAX: 859-257-5737, ranjana.singh@uky.edu
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.10.039