Genetic risk for alcoholic chronic pancreatitis

• Published in: International journal of environmental research and public health Vol. 8; no. 7; pp. 2747 - 2757
• Main Authors: da Costa, Marianges Zadrozny Gouvêa, Guarita, Dulce Reis, Ono-Nita, Suzane Kioko, Paranaguá-Vezozzo, Denise Cerqueira, Felga, Guilherme Eduardo Gonçalves, Pedroso, Martha Regina Arcon, de Souza, Marcelo Moreira Tavares, Nasser, Paulo Dominguez, Ferreira, Camila da Silva, Carrilho, Flair José
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-07-2011; Molecular Diversity Preservation International (MDPI)
• Subjects: Alcoholism; Alcoholism - complications; Chronic illnesses; Ethanol - metabolism; Ethanol - toxicity; Genetics; Health risk assessment; Humans; Mutation; Pancreas; Pancreatitis, Alcoholic - epidemiology; Pancreatitis, Alcoholic - genetics; Pancreatitis, Alcoholic - metabolism; Review; serine protease inhibitor kazal type 1; genetics; pancreatic diseases; alcoholism; cationic trypsinogen; cystic fibrosis transmembrane conductance regulator; chymotrypsin C
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph8072747

In recent years many studies have examined the genetic predisposition to pancreatic diseases. Pancreatic disease of an alcoholic etiology was determined to be a multi-factorial disease, where environmental factors interact with the genetic profile of the individual. In this review we discuss the main results from studies examining the frequency of genetic mutations in alcoholic chronic pancreatitis.