Genetic homogeneity of goat malaria parasites in Asia and Africa suggests their expansion with domestic goat host

• Published in: Scientific reports Vol. 8; no. 1; pp. 5827 - 7
• Main Authors: Kaewthamasorn, Morakot, Takeda, Mika, Saiwichai, Tawee, Gitaka, Jesse N., Tiawsirisup, Sonthaya, Imasato, Yuhei, Mossaad, Ehab, Sarani, Ali, Kaewlamun, Winai, Channumsin, Manun, Chaiworakul, Suchart, Katepongpun, Wichit, Teeveerapunya, Surapong, Panthong, Jarus, Mureithi, Dominic K., Bawm, Saw, Htun, Lat Lat, Win, Mar Mar, Ismail, Ahmed Ali, Ibrahim, Abdalla Mohamed, Suganuma, Keisuke, Hakimi, Hassan, Nakao, Ryo, Katakura, Ken, Asada, Masahito, Kaneko, Osamu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11-04-2018; Nature Publishing Group
• Subjects: 14/63; 45/22; 45/23; 631/181/757; 631/326/417/2548; Africa - epidemiology; Animals; Asia - epidemiology; Blood; Caprinae; Deoxyribonucleic acid; DNA; DNA, Mitochondrial - genetics; DNA, Mitochondrial - isolation & purification; DNA, Protozoan - genetics; DNA, Protozoan - isolation & purification; Domestic animals; Domestication; Female; Goats; Goats - parasitology; Humanities and Social Sciences; Malaria; Malaria - blood; Malaria - epidemiology; Malaria - parasitology; Malaria - veterinary; Male; Mitochondrial DNA; multidisciplinary; Nucleotide sequence; Parasites; Phylogeny; Plasmodium; Plasmodium - genetics; Plasmodium - isolation & purification; Prevalence; Science; Science (multidisciplinary); Sequence Analysis, DNA; Ungulates; Vector-borne diseases; Asia; Africa
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-24048-0

Plasmodium
was first identified in a goat in Angola in 1923, and only recently characterized by DNA isolation from a goat blood sample in Zambia. Goats were first domesticated in the Fertile Crescent approximately 10,000 years ago, and are now globally distributed. It is not known if the
Plasmodium
identified in African goats originated from parasites circulating in the local ungulates, or if it co-evolved in the goat before its domestication. To address this question, we performed PCR-based surveillance using a total of 1,299 goat blood samples collected from Sudan and Kenya in Africa, Iran in west Asia, and Myanmar and Thailand in southeast Asia.
Plasmodium
DNA was detected from all locations, suggesting that the parasite is not limited to Africa, but widely distributed. Whole mitochondrial DNA sequences revealed that there was only one nucleotide substitution between Zambian/Kenyan samples and others, supporting the existence of a goat-specific
Plasmodium
species, presumably
Plasmodium caprae
, rather than infection of goats by local ungulate malaria parasites. We also present the first photographic images of
P
.
caprae
, from one Kenyan goat sample.