Profile of chromosomal aberrations in different gestational age spontaneous abortions detected by comparative genomic hybridization
Abstract Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. Results The frequency of detected chromosomal aberration...
Saved in:
| Published in: | European journal of obstetrics & gynecology and reproductive biology Vol. 131; no. 2; pp. 127 - 131 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Shannon
Elsevier Ireland Ltd
01-04-2007
Elsevier |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Abstract Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. Results The frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance ( p = 0.0847). However, due to the low number of blighted ovum specimens analyzed ( n = 8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%). Conclusions We describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH. |
|---|---|
| AbstractList | To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions.
In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization.
The frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance (
p
=
0.0847). However, due to the low number of blighted ovum specimens analyzed (
n
=
8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%).
We describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH. Abstract Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. Results The frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance ( p = 0.0847). However, due to the low number of blighted ovum specimens analyzed ( n = 8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%). Conclusions We describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH. OBJECTIVETo determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions.STUDY DESIGNIn the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization.RESULTSThe frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance (p=0.0847). However, due to the low number of blighted ovum specimens analyzed (n=8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%).CONCLUSIONSWe describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH. To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. The frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance (p=0.0847). However, due to the low number of blighted ovum specimens analyzed (n=8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%). We describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH. |
| Author | Michailova, Gergana I Azmanov, Dimitar N Milachich, Tania V Dimitrova, Violeta G Maznejkova, Valentina T Karagiozova, Zivka H Chernev, Todor A Toncheva, Draga I Zaharieva, Boriana M |
| Author_xml | – sequence: 1 fullname: Azmanov, Dimitar N – sequence: 2 fullname: Milachich, Tania V – sequence: 3 fullname: Zaharieva, Boriana M – sequence: 4 fullname: Michailova, Gergana I – sequence: 5 fullname: Dimitrova, Violeta G – sequence: 6 fullname: Karagiozova, Zivka H – sequence: 7 fullname: Maznejkova, Valentina T – sequence: 8 fullname: Chernev, Todor A – sequence: 9 fullname: Toncheva, Draga I |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18670585$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16759788$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkkFv1DAQhS1URLeFf4BQLnDLMk7s2LkgoarQSpVAAs6WY0-2Dom92NlKy5U_jtOsVIkLvliyvvc882YuyJkPHgl5TWFLgTbvhy0OYRe7bQXQbIFtoRbPyIZKUZWi4eyMbKAGWlaU8nNykdIA-dR1-4Kc00bwVki5IX--xtC7EYvQF-Y-himkMOmx0B3GqGcXfCqcL6zre4zo52KHaX58X6AdFmkf_Kw9hkPKohBXicUZzYy26I6FCdNeL14PmNU-TM4U98cuOut-Pzq9JM97PSZ8dbovyY9P19-vbsq7L59vrz7elYZTOpeUWzAgRM9l17JGaNZ1TS81b2tDEYQ1VnNtqp4bFK1By0TdNqyVaCXIVtaX5N3qu4_h1yH3oSaXDI7jWr4SUFMuGcsgW0ETQ0oRe7WPbtLxqCioJXw1qDV8tYSvgKkcfpa9Ofkfugntk-iUdgbengCdjB77qL1x6YmTjQAueeY-rBzmNB4cRpWMQ59bcjHHqmxw_6vkXwMzOu_ynz_xiGkIh5jnlxRVqVKgvi2LsuwJNAAVo6L-C32dvw8 |
| CODEN | EOGRAL |
| CitedBy_id | crossref_primary_10_1016_j_ejogrb_2009_07_023 crossref_primary_10_1186_1471_2350_10_89 crossref_primary_10_1002_ajmg_a_32058 crossref_primary_10_1186_s12916_015_0374_8 crossref_primary_10_26416_ObsGin_67_1_2019_2292 crossref_primary_10_1007_s10815_010_9460_1 crossref_primary_10_1007_s10815_017_1009_0 crossref_primary_10_1038_s10038_019_0694_1 crossref_primary_10_1016_j_morpho_2014_02_001 crossref_primary_10_1016_j_repbio_2017_03_003 crossref_primary_10_1111_cge_12727 crossref_primary_10_1055_s_0039_1696948 crossref_primary_10_1097_GCO_0b013e3282f88e0c crossref_primary_10_1007_s41974_017_0015_7 crossref_primary_10_29252_ijrm_15_8_503 crossref_primary_10_1016_j_mgene_2014_09_004 crossref_primary_10_1142_S2661318223500020 crossref_primary_10_12659_MSM_881969 crossref_primary_10_1007_s10815_019_01415_y crossref_primary_10_1007_s43032_022_01073_z crossref_primary_10_1093_humrep_dez229 crossref_primary_10_1007_s41975_017_0019_8 |
| Cites_doi | 10.1111/j.1600-0897.1998.tb00342.x 10.1016/0028-2243(92)90257-Y 10.1093/humrep/16.9.1954 10.1016/0168-9525(86)90194-0 10.1016/S0015-0282(98)00445-2 10.1002/pd.115 10.1111/j.1479-828X.1996.tb02719.x 10.5858/2001-125-0081-CGH 10.1086/421250 10.1002/pd.1230 10.1007/s004390050459 10.1002/(SICI)1097-0223(199902)19:2<100::AID-PD468>3.0.CO;2-H 10.1016/0959-437X(93)90111-2 10.1093/humrep/13.4.805 10.1093/nar/16.15.7730 10.1007/BF00285104 10.1097/00003081-198612000-00014 10.1053/beog.2000.0124 10.1002/(SICI)1096-9926(199905)59:5<325::AID-TERA3>3.0.CO;2-N 10.1086/302878 10.1007/s004390050638 10.1002/pd.1970150202 10.1159/000015409 10.1038/sj.ejhg.5200669 |
| ContentType | Journal Article |
| Copyright | Elsevier Ireland Ltd 2006 Elsevier Ireland Ltd 2007 INIST-CNRS |
| Copyright_xml | – notice: Elsevier Ireland Ltd – notice: 2006 Elsevier Ireland Ltd – notice: 2007 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.ejogrb.2006.04.037 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1872-7654 |
| EndPage | 131 |
| ExternalDocumentID | 10_1016_j_ejogrb_2006_04_037 16759788 18670585 S0301211506002417 1_s2_0_S0301211506002417 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29G 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXKI AAXUO ABBQC ABFNM ABJNI ABMAC ABMZM ABXDB ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFJKZ AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJRQY AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEC HMK HMO HVGLF HZ~ IHE J1W KOM M29 M2X M41 MO0 N9A NQ- O-L O9- OAUVE OQ. OZT P-8 P-9 P2P PC. PH~ Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SSH SSZ T5K WUQ Z5R ZGI ~G- AAIAV ABLVK ABYKQ AJBFU EFLBG LCYCR ABPIF IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c511t-15d0c077f58b9467a4bb6f8a593c1e07dcda5ac2f5ce79ced47396498ed808983 |
| ISSN | 0301-2115 |
| IngestDate | Fri Oct 25 04:41:39 EDT 2024 Thu Sep 26 17:46:33 EDT 2024 Sat Sep 28 07:42:15 EDT 2024 Sun Oct 22 16:06:00 EDT 2023 Fri Feb 23 02:28:05 EST 2024 Tue Oct 15 22:55:34 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Comparative genomic hybridization Chromosomal aberrations Spontaneous abortions Chromosomal aberration Pregnancy disorders Gynecology Developmental stage Gene expression Abortion Obstetrics Gestational age |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c511t-15d0c077f58b9467a4bb6f8a593c1e07dcda5ac2f5ce79ced47396498ed808983 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 16759788 |
| PQID | 70315844 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_70315844 crossref_primary_10_1016_j_ejogrb_2006_04_037 pubmed_primary_16759788 pascalfrancis_primary_18670585 elsevier_sciencedirect_doi_10_1016_j_ejogrb_2006_04_037 elsevier_clinicalkeyesjournals_1_s2_0_S0301211506002417 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-04-01 |
| PublicationDateYYYYMMDD | 2007-04-01 |
| PublicationDate_xml | – month: 04 year: 2007 text: 2007-04-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Shannon |
| PublicationPlace_xml | – name: Shannon – name: Ireland |
| PublicationTitle | European journal of obstetrics & gynecology and reproductive biology |
| PublicationTitleAlternate | Eur J Obstet Gynecol Reprod Biol |
| PublicationYear | 2007 |
| Publisher | Elsevier Ireland Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ireland Ltd – name: Elsevier |
| References | Tabet, Aboura, Dauge (bib24) 2001; 21 Lomax, Tang, Separovic (bib11) 2000; 66 Guttenbach, Engel, Schmid (bib3) 1997; 100 Benkhalifa, Kasakyan, Clement (bib8) 2005; 25 Dry (bib14) 1988; 16 Hassold (bib27) 1986; 2 Ford, Wilkin, Thomas (bib21) 1996; 36 Barrett, Lomax, Loukianova, Tang, Lestou, Kalousek (bib12) 2001; 125 Goddijn, Leschot (bib1) 2000; 14 Schaeffer, Chung, Heretis, Wong, Ledbetter, Martin (bib9) 2004; 74 Wolstenholme (bib5) 1995; 15 Sandalinas, Sadowy, Alikani, Calderon, Cohen, Munne (bib4) 2001; 16 Bell, Van Deerlin, Haddad, Feinberg (bib7) 1999; 71 Fritz, Hallermann, Olert (bib13) 2001; 9 Ohno, Maeda, Matsunobu (bib19) 1991; 77 Dejmec, Voitassak, Malova (bib20) 1992; 46 Daniely, Barkai, Goldman, Aviram-Goldring (bib23) 1999; 19 Reddy (bib25) 1997; 101 Rooney, Czepulkowsky (bib15) 1997 Hassold, Hunt, Sherman (bib2) 1993; 3 Machin, Crolla (bib26) 1974; 23 Daniely, Barkai, Goldman, Aviram-Goldring (bib17) 1999; 86 Dewald, Michels (bib18) 1986; 29 Daniely, Aviram-Goldring, Barkai, Goldman (bib10) 1998; 13 Lestou, Lomax, Barrett, Kalousek (bib16) 1999; 59 Qumsiyeh (bib22) 1998; 7 Kalousek (bib6) 1998; 39 Daniely (10.1016/j.ejogrb.2006.04.037_bib10) 1998; 13 Goddijn (10.1016/j.ejogrb.2006.04.037_bib1) 2000; 14 Machin (10.1016/j.ejogrb.2006.04.037_bib26) 1974; 23 Wolstenholme (10.1016/j.ejogrb.2006.04.037_bib5) 1995; 15 Lestou (10.1016/j.ejogrb.2006.04.037_bib16) 1999; 59 Sandalinas (10.1016/j.ejogrb.2006.04.037_bib4) 2001; 16 Schaeffer (10.1016/j.ejogrb.2006.04.037_bib9) 2004; 74 Tabet (10.1016/j.ejogrb.2006.04.037_bib24) 2001; 21 Fritz (10.1016/j.ejogrb.2006.04.037_bib13) 2001; 9 Dry (10.1016/j.ejogrb.2006.04.037_bib14) 1988; 16 Lomax (10.1016/j.ejogrb.2006.04.037_bib11) 2000; 66 Daniely (10.1016/j.ejogrb.2006.04.037_bib17) 1999; 86 Qumsiyeh (10.1016/j.ejogrb.2006.04.037_bib22) 1998; 7 Dewald (10.1016/j.ejogrb.2006.04.037_bib18) 1986; 29 Dejmec (10.1016/j.ejogrb.2006.04.037_bib20) 1992; 46 Hassold (10.1016/j.ejogrb.2006.04.037_bib27) 1986; 2 Barrett (10.1016/j.ejogrb.2006.04.037_bib12) 2001; 125 Hassold (10.1016/j.ejogrb.2006.04.037_bib2) 1993; 3 Rooney (10.1016/j.ejogrb.2006.04.037_bib15) 1997 Guttenbach (10.1016/j.ejogrb.2006.04.037_bib3) 1997; 100 Reddy (10.1016/j.ejogrb.2006.04.037_bib25) 1997; 101 Bell (10.1016/j.ejogrb.2006.04.037_bib7) 1999; 71 Ohno (10.1016/j.ejogrb.2006.04.037_bib19) 1991; 77 Benkhalifa (10.1016/j.ejogrb.2006.04.037_bib8) 2005; 25 Kalousek (10.1016/j.ejogrb.2006.04.037_bib6) 1998; 39 Daniely (10.1016/j.ejogrb.2006.04.037_bib23) 1999; 19 Ford (10.1016/j.ejogrb.2006.04.037_bib21) 1996; 36 |
| References_xml | – volume: 39 start-page: 108 year: 1998 end-page: 119 ident: bib6 article-title: Clinical significance of morphologic and genetic examination of spontaneously aborted embryos publication-title: Am J Reprod Immunol contributor: fullname: Kalousek – volume: 23 start-page: 183 year: 1974 end-page: 198 ident: bib26 article-title: Chromosome constitution of 500 infants dying during the prenatal period publication-title: Hum Genet contributor: fullname: Crolla – volume: 71 start-page: 334 year: 1999 end-page: 341 ident: bib7 article-title: Cytogenetic diagnosis of “normal 46, XX” karyotypes in spontaneous abortions frequently may be misleading publication-title: Fertil Steril contributor: fullname: Feinberg – volume: 86 start-page: 51 year: 1999 end-page: 55 ident: bib17 article-title: Structural unbalanced chromosome rearrangements resolved by comparative genomic hybridization publication-title: Cytogenet Cell Genet contributor: fullname: Aviram-Goldring – volume: 2 start-page: 105 year: 1986 end-page: 110 ident: bib27 article-title: Chromosome abnormalities in human reproductive wastage publication-title: Trends Genet contributor: fullname: Hassold – volume: 21 start-page: 613 year: 2001 end-page: 618 ident: bib24 article-title: Cytogenetic analysis of trophoblasts by comparative genomic hybridization in embryo-fetal development anomalies publication-title: Prenatal Diagn contributor: fullname: Dauge – volume: 16 start-page: 7730 year: 1988 ident: bib14 article-title: A quick and easy method for the purification of DNA CVS publication-title: Nucl Acids Res contributor: fullname: Dry – volume: 14 start-page: 855 year: 2000 end-page: 865 ident: bib1 article-title: Genetic aspects of miscarriage publication-title: Baillieres Best Pract Res Clin Obstet Gynaecol contributor: fullname: Leschot – volume: 74 start-page: 1168 year: 2004 end-page: 1174 ident: bib9 article-title: Comparative genomic hybridization-array analysis enhances the detection of aneuploidies and submicroscopic imbalances in spontaneous miscarriages publication-title: Am J Hum Genet contributor: fullname: Martin – volume: 13 start-page: 805 year: 1998 end-page: 809 ident: bib10 article-title: Detection of chromosomal aberration in fetuses arising from recurrent spontaneous abortion by comparative genomic hybridization publication-title: Hum Reprod contributor: fullname: Goldman – volume: 125 start-page: 81 year: 2001 end-page: 84 ident: bib12 article-title: Comparative genomic hybridization: a new tool for reproductive pathology publication-title: Arch Pathol Lab Med contributor: fullname: Kalousek – volume: 19 start-page: 100 year: 1999 end-page: 104 ident: bib23 article-title: Detection of numerical chromosome aberrations by comparative genomic hybridization publication-title: Prenatal Diagn contributor: fullname: Aviram-Goldring – volume: 9 start-page: 539 year: 2001 end-page: 547 ident: bib13 article-title: Cytogenetic analyzes of culture failures by comparative genomic hybridisation (CGH)-Re-evaluation of chromosome aberration rates in early spontaneous abortions publication-title: Eur J Hum Genet contributor: fullname: Olert – volume: 29 start-page: 865 year: 1986 end-page: 885 ident: bib18 article-title: Recurrent miscarriages: cytogenetic causes and genetic counseling of affected families publication-title: Clin Obstet Gynecol contributor: fullname: Michels – volume: 59 start-page: 325 year: 1999 end-page: 330 ident: bib16 article-title: Screening of human placentas for chromosomal mosaicism using comparative genomic hybridization publication-title: Teratology contributor: fullname: Kalousek – volume: 7 start-page: 210 year: 1998 end-page: 212 ident: bib22 article-title: Chromosome abnormalities in the placenta and spontaneous abortions publication-title: J Matern Fetal Med contributor: fullname: Qumsiyeh – volume: 101 start-page: 339 year: 1997 end-page: 345 ident: bib25 article-title: Double trisomy in spontaneous abortions publication-title: Hum Genet contributor: fullname: Reddy – volume: 100 start-page: 1 year: 1997 end-page: 21 ident: bib3 article-title: Analysis of structural and numerical chromosome abnormalities in sperm of normal men and carriers of constitutional chromosome aberrations: a review publication-title: Hum Genet contributor: fullname: Schmid – volume: 46 start-page: 129 year: 1992 end-page: 136 ident: bib20 article-title: Cytogenetic analysis of 1508 spontaneous abortions originating from South Slovakia publication-title: Eur J Obstet Gynecol Reprod Biol contributor: fullname: Malova – volume: 16 start-page: 1954 year: 2001 end-page: 1958 ident: bib4 article-title: Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage publication-title: Hum Reprod contributor: fullname: Munne – volume: 15 start-page: 109 year: 1995 end-page: 121 ident: bib5 article-title: An audit of trisomy 16 in man publication-title: Prenatal Diagn contributor: fullname: Wolstenholme – volume: 36 start-page: 314 year: 1996 end-page: 318 ident: bib21 article-title: A 13-year cytogenetic study of spontaneous abortions: clinical applications of testing publication-title: Aust N Z J Obstet Gynecol contributor: fullname: Thomas – volume: 77 start-page: 394 year: 1991 end-page: 398 ident: bib19 article-title: A cytogenetic study of spontaneous abortions with direct analysis of chorionic vili publication-title: Obstet Gynecol contributor: fullname: Matsunobu – year: 1997 ident: bib15 article-title: Essential techniques series: human chromosome preparation contributor: fullname: Czepulkowsky – volume: 66 start-page: 1516 year: 2000 end-page: 1521 ident: bib11 article-title: Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions publication-title: Am J Hum Genet contributor: fullname: Separovic – volume: 25 start-page: 894 year: 2005 end-page: 900 ident: bib8 article-title: Array comparative genomic hybridization profiling of first-trimester spontaneous abortions that fail to grow in vitro publication-title: Prenatal Diagn contributor: fullname: Clement – volume: 3 start-page: 398 year: 1993 end-page: 403 ident: bib2 article-title: Trisomy in humans: incidence, origin and etiology publication-title: Curr Opin Genet Dev contributor: fullname: Sherman – volume: 39 start-page: 108 year: 1998 ident: 10.1016/j.ejogrb.2006.04.037_bib6 article-title: Clinical significance of morphologic and genetic examination of spontaneously aborted embryos publication-title: Am J Reprod Immunol doi: 10.1111/j.1600-0897.1998.tb00342.x contributor: fullname: Kalousek – volume: 46 start-page: 129 year: 1992 ident: 10.1016/j.ejogrb.2006.04.037_bib20 article-title: Cytogenetic analysis of 1508 spontaneous abortions originating from South Slovakia publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/0028-2243(92)90257-Y contributor: fullname: Dejmec – volume: 16 start-page: 1954 year: 2001 ident: 10.1016/j.ejogrb.2006.04.037_bib4 article-title: Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage publication-title: Hum Reprod doi: 10.1093/humrep/16.9.1954 contributor: fullname: Sandalinas – volume: 2 start-page: 105 year: 1986 ident: 10.1016/j.ejogrb.2006.04.037_bib27 article-title: Chromosome abnormalities in human reproductive wastage publication-title: Trends Genet doi: 10.1016/0168-9525(86)90194-0 contributor: fullname: Hassold – volume: 71 start-page: 334 year: 1999 ident: 10.1016/j.ejogrb.2006.04.037_bib7 article-title: Cytogenetic diagnosis of “normal 46, XX” karyotypes in spontaneous abortions frequently may be misleading publication-title: Fertil Steril doi: 10.1016/S0015-0282(98)00445-2 contributor: fullname: Bell – volume: 21 start-page: 613 issue: 8 year: 2001 ident: 10.1016/j.ejogrb.2006.04.037_bib24 article-title: Cytogenetic analysis of trophoblasts by comparative genomic hybridization in embryo-fetal development anomalies publication-title: Prenatal Diagn doi: 10.1002/pd.115 contributor: fullname: Tabet – volume: 36 start-page: 314 year: 1996 ident: 10.1016/j.ejogrb.2006.04.037_bib21 article-title: A 13-year cytogenetic study of spontaneous abortions: clinical applications of testing publication-title: Aust N Z J Obstet Gynecol doi: 10.1111/j.1479-828X.1996.tb02719.x contributor: fullname: Ford – volume: 125 start-page: 81 issue: 1 year: 2001 ident: 10.1016/j.ejogrb.2006.04.037_bib12 article-title: Comparative genomic hybridization: a new tool for reproductive pathology publication-title: Arch Pathol Lab Med doi: 10.5858/2001-125-0081-CGH contributor: fullname: Barrett – volume: 74 start-page: 1168 issue: 6 year: 2004 ident: 10.1016/j.ejogrb.2006.04.037_bib9 article-title: Comparative genomic hybridization-array analysis enhances the detection of aneuploidies and submicroscopic imbalances in spontaneous miscarriages publication-title: Am J Hum Genet doi: 10.1086/421250 contributor: fullname: Schaeffer – volume: 25 start-page: 894 issue: 10 year: 2005 ident: 10.1016/j.ejogrb.2006.04.037_bib8 article-title: Array comparative genomic hybridization profiling of first-trimester spontaneous abortions that fail to grow in vitro publication-title: Prenatal Diagn doi: 10.1002/pd.1230 contributor: fullname: Benkhalifa – year: 1997 ident: 10.1016/j.ejogrb.2006.04.037_bib15 contributor: fullname: Rooney – volume: 100 start-page: 1 year: 1997 ident: 10.1016/j.ejogrb.2006.04.037_bib3 article-title: Analysis of structural and numerical chromosome abnormalities in sperm of normal men and carriers of constitutional chromosome aberrations: a review publication-title: Hum Genet doi: 10.1007/s004390050459 contributor: fullname: Guttenbach – volume: 19 start-page: 100 issue: 2 year: 1999 ident: 10.1016/j.ejogrb.2006.04.037_bib23 article-title: Detection of numerical chromosome aberrations by comparative genomic hybridization publication-title: Prenatal Diagn doi: 10.1002/(SICI)1097-0223(199902)19:2<100::AID-PD468>3.0.CO;2-H contributor: fullname: Daniely – volume: 3 start-page: 398 year: 1993 ident: 10.1016/j.ejogrb.2006.04.037_bib2 article-title: Trisomy in humans: incidence, origin and etiology publication-title: Curr Opin Genet Dev doi: 10.1016/0959-437X(93)90111-2 contributor: fullname: Hassold – volume: 13 start-page: 805 year: 1998 ident: 10.1016/j.ejogrb.2006.04.037_bib10 article-title: Detection of chromosomal aberration in fetuses arising from recurrent spontaneous abortion by comparative genomic hybridization publication-title: Hum Reprod doi: 10.1093/humrep/13.4.805 contributor: fullname: Daniely – volume: 16 start-page: 7730 year: 1988 ident: 10.1016/j.ejogrb.2006.04.037_bib14 article-title: A quick and easy method for the purification of DNA CVS publication-title: Nucl Acids Res doi: 10.1093/nar/16.15.7730 contributor: fullname: Dry – volume: 23 start-page: 183 year: 1974 ident: 10.1016/j.ejogrb.2006.04.037_bib26 article-title: Chromosome constitution of 500 infants dying during the prenatal period publication-title: Hum Genet doi: 10.1007/BF00285104 contributor: fullname: Machin – volume: 29 start-page: 865 year: 1986 ident: 10.1016/j.ejogrb.2006.04.037_bib18 article-title: Recurrent miscarriages: cytogenetic causes and genetic counseling of affected families publication-title: Clin Obstet Gynecol doi: 10.1097/00003081-198612000-00014 contributor: fullname: Dewald – volume: 14 start-page: 855 issue: 5 year: 2000 ident: 10.1016/j.ejogrb.2006.04.037_bib1 article-title: Genetic aspects of miscarriage publication-title: Baillieres Best Pract Res Clin Obstet Gynaecol doi: 10.1053/beog.2000.0124 contributor: fullname: Goddijn – volume: 59 start-page: 325 year: 1999 ident: 10.1016/j.ejogrb.2006.04.037_bib16 article-title: Screening of human placentas for chromosomal mosaicism using comparative genomic hybridization publication-title: Teratology doi: 10.1002/(SICI)1096-9926(199905)59:5<325::AID-TERA3>3.0.CO;2-N contributor: fullname: Lestou – volume: 66 start-page: 1516 year: 2000 ident: 10.1016/j.ejogrb.2006.04.037_bib11 article-title: Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions publication-title: Am J Hum Genet doi: 10.1086/302878 contributor: fullname: Lomax – volume: 101 start-page: 339 issue: 3 year: 1997 ident: 10.1016/j.ejogrb.2006.04.037_bib25 article-title: Double trisomy in spontaneous abortions publication-title: Hum Genet doi: 10.1007/s004390050638 contributor: fullname: Reddy – volume: 77 start-page: 394 year: 1991 ident: 10.1016/j.ejogrb.2006.04.037_bib19 article-title: A cytogenetic study of spontaneous abortions with direct analysis of chorionic vili publication-title: Obstet Gynecol contributor: fullname: Ohno – volume: 7 start-page: 210 issue: 4 year: 1998 ident: 10.1016/j.ejogrb.2006.04.037_bib22 article-title: Chromosome abnormalities in the placenta and spontaneous abortions publication-title: J Matern Fetal Med contributor: fullname: Qumsiyeh – volume: 15 start-page: 109 year: 1995 ident: 10.1016/j.ejogrb.2006.04.037_bib5 article-title: An audit of trisomy 16 in man publication-title: Prenatal Diagn doi: 10.1002/pd.1970150202 contributor: fullname: Wolstenholme – volume: 86 start-page: 51 issue: 1 year: 1999 ident: 10.1016/j.ejogrb.2006.04.037_bib17 article-title: Structural unbalanced chromosome rearrangements resolved by comparative genomic hybridization publication-title: Cytogenet Cell Genet doi: 10.1159/000015409 contributor: fullname: Daniely – volume: 9 start-page: 539 issue: 7 year: 2001 ident: 10.1016/j.ejogrb.2006.04.037_bib13 article-title: Cytogenetic analyzes of culture failures by comparative genomic hybridisation (CGH)-Re-evaluation of chromosome aberration rates in early spontaneous abortions publication-title: Eur J Hum Genet doi: 10.1038/sj.ejhg.5200669 contributor: fullname: Fritz |
| SSID | ssj0000339 |
| Score | 2.0146756 |
| Snippet | Abstract Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the... To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. In the study, 106 spontaneous abortions... OBJECTIVETo determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions.STUDY DESIGNIn the study, 106... |
| SourceID | proquest crossref pubmed pascalfrancis elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 127 |
| SubjectTerms | Abortion, Spontaneous - genetics Adult Aneuploidy Biological and medical sciences Chromosomal aberrations Chromosome Aberrations - statistics & numerical data Chromosomes, Human, X Comparative genomic hybridization Diseases of mother, fetus and pregnancy DNA - genetics DNA Fingerprinting - methods Female Gestational Age Gynecology. Andrology. Obstetrics Humans Medical sciences Monosomy Nucleic Acid Hybridization - methods Obstetrics and Gynecology Pregnancy Pregnancy Trimester, First - genetics Pregnancy Trimester, Second - genetics Pregnancy. Fetus. Placenta Spontaneous abortions |
| Title | Profile of chromosomal aberrations in different gestational age spontaneous abortions detected by comparative genomic hybridization |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0301211506002417 https://dx.doi.org/10.1016/j.ejogrb.2006.04.037 https://www.ncbi.nlm.nih.gov/pubmed/16759788 https://search.proquest.com/docview/70315844 |
| Volume | 131 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFBZNB2Mwxu7LLp0e9hYc5ES25MeyZWsfWsaajdEXIdtyk9DaJU4L2ev--M6x5EsIYRfYiwl2FCs-n3Uu-s45hLwDpT3mmnMPS694uBOIycrMi4U_EnGoecYwG_noTJx-lx8mfLLXq_s5tuf-q6ThHMgaM2f_QtrNj8IJ-AwyhyNIHY5_JPfPtgl3RRefIdeuLK6wHkBslsuWOF73RVkNcH-pDggifwcps2AwGqTGIkDskNTgZoO1VpNOwXAs8Yrs-tkaM79cTufOaL-zfIsYoIWdAcoKeBfr3CRtKSgss1lVoa149fONsP_hjyudF7fVQomZWXo5OB02mJlfIjPU9raaakw3-9ZcPNczjArc2k7TBQgi14OTzthkpueXhb3-yWCGqh4cDzeCIqLDpakidXW2zjFmBMHUW4pUlSnGfA8cX7ubbuzCLwV4GqEtaN1oBqeg5h0P3a7zvi1o4EwG970tbWQDI4uhWRQXy9jtfPEhG4tW-zacyDOcFs6K4VYp90WP3BnB6omL93nwpTUvxlV7vOZP1PmgFWlx-0677K3717qEVSCz7Vt2-1eVnTV9SB44B4keWmQ_Insmf0zunjgKyBPy0wGcFhntAJx2AE7nOW0ATjsAp_AYaQfgtAE4rQFO4zXtAJw6gNMNgD8lXz9Opu-PPNdJxEvAoVh5fpCyhAmRBTKOwDTQPI7DTOogGie-YSJNUh3oZJQFiRFRYlIuxlHII2lSyWQkx8_Ifl7k5gWhMuPgBBjNEqzrZJgWaSQS4fMs9bkOTJ949fNW17ZgjKqZlAtl5YO9X0PFuAL59ImohaLqZGhQ36Z0r2WpfFWOFFNb-OiOdOayNYMV4O839zzYkH47URkKFsigT97WcFCgbnAP0cpFYbsL8Fl4nzy3KGnHhiKIhJQv_3lar8i99l1-TfZXyxvzhvTK9OagegV-AXXpCh4 |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Profile+of+chromosomal+aberrations+in+different+gestational+age+spontaneous+abortions+detected+by+comparative+genomic+hybridization&rft.jtitle=European+journal+of+obstetrics+%26+gynecology+and+reproductive+biology&rft.au=Azmanov%2C+Dimitar+N.&rft.au=Milachich%2C+Tania+V.&rft.au=Zaharieva%2C+Boriana+M.&rft.au=Michailova%2C+Gergana+I.&rft.date=2007-04-01&rft.pub=Elsevier+Ireland+Ltd&rft.issn=0301-2115&rft.eissn=1872-7654&rft.volume=131&rft.issue=2&rft.spage=127&rft.epage=131&rft_id=info:doi/10.1016%2Fj.ejogrb.2006.04.037&rft.externalDocID=S0301211506002417 |
| thumbnail_m | http://sdu.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F03012115%2FS0301211507X01520%2Fcov150h.gif |