Towards discovery‐driven translational research in breast cancer

• Published in: The FEBS journal Vol. 272; no. 1; pp. 2 - 15
• Main Authors: Celis, Julio E., Moreira, José M. A., Gromova, Irina, Cabezon, Teresa, Ralfkiaer, Ulrik, Guldberg, Per, Straten, Per thor, Mouridsen, Henning, Friis, Esbern, Holm, Dorte, Rank, Fritz, Gromov, Pavel
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-01-2005; Blackwell Publishing Ltd
• Subjects: Biomarkers, Tumor; breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - therapy; functional genomics; Humans; individualised medicine; Protein Biosynthesis; proteomics; signaling pathways; systems biology; translational research
• ISSN: 1742-464X; 1742-4658
• DOI: 10.1111/j.1432-1033.2004.04418.x

Discovery‐driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics, promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long‐term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic intervention, to identify signalling pathways affected in individual tumours, as well as to integrate multiplatform ‘omic’ data sets collected from tissue samples obtained from individual patients. The ultimate goal of this initiative is to coalesce knowledge‐based complementary procedures into a systems biology approach to fight breast cancer.