Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells

Diet-derived lipids may influence cytokine-mediated endothelial cell dysfunction, including TNF-induced apoptosis. To test this hypothesis, oxidative stress, intracellular calcium levels, endothelial barrier function, cell viability, and apoptosis were measured in vascular endothelial cells treated...

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Bibliographic Details
Published in:	Journal of lipid research Vol. 38; no. 10; pp. 2155 - 2167
Main Authors:	Toborek, M, Blanc, E M, Kaiser, S, Mattson, M P, Hennig, B
Format:	Journal Article
Language:	English
Published:	United States Elsevier 01-10-1997
Subjects:	Animals Apoptosis - drug effects Aurintricarboxylic Acid - pharmacology Calcium - metabolism Cell Survival - drug effects Cells, Cultured DNA Fragmentation Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Flow Cytometry Fluorescent Dyes - metabolism Formazans - metabolism Linoleic Acid - pharmacology Microscopy, Fluorescence Mitochondria - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology Propyl Gallate - pharmacology Serum Albumin, Bovine - metabolism Swine Tetrazolium Salts - metabolism Tumor Necrosis Factor-alpha - pharmacology Vitamin E - pharmacology
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