A single acute exposure to a chemotherapeutic agent induces hyper-recombination in distantly descendant cells and in their neighbors

Homologous recombination can induce tumorigenic sequence rearrangements. Here, we show that persistent hyper-recombination can be induced following exposure to a bifunctional alkylating agent, mitomycin C (MMC), and that the progeny of exposed cells induce a hyper-recombination phenotype in unexpose...

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Bibliographic Details
Published in:	Oncogene Vol. 24; no. 32; pp. 5016 - 5025
Main Authors:	RUGO, Rebecca E, ALMEIDA, Karen H, HENDRICKS, Carrie A, JONNALAGADDA, Vidya S, ENGELWARD, Bevin P
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing 28-07-2005 Nature Publishing Group
Subjects:	Animals Antineoplastic Agents - pharmacology Biological and medical sciences Bystander Effect Cell Communication Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes DNA damage Fundamental and applied biological sciences. Psychology Genomes Homologous recombination Mice Mitomycin - pharmacology Mitomycin C Molecular and cellular biology Mutation Offspring Phenotypes Radiation Recombination, Genetic - drug effects Stem Cells - cytology Stem Cells - drug effects Stem Cells - physiology United States > US Massachusetts genetic instability bystander DNA Homologous recombination DNA damage Genetics Instability Exposure Lesion persistent Carcinogenesis
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