Effect of Corticosteroid Withdrawal on Tacrolimus and Mycophenolate Mofetil Exposure in a Randomized Multicenter Study

As corticosteroid‐sparing protocols are increasingly utilized in kidney transplant recipients, it is crucial to understand potential drug interactions between tacrolimus (TAC) and the effect of corticosteroid withdrawal as well as to characterize dose adjustments of mycophenolate mofetil (MMF) in th...

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Bibliographic Details
Published in:	American journal of transplantation Vol. 13; no. 2; pp. 474 - 484
Main Authors:	Shihab, F. S., Lee, S. T., Smith, L. D., Woodle, E. S., Pirsch, J. D., Gaber, A. O., Henning, A. K., Reisfield, R., Fitzsimmons, W., Holman, J.
Format:	Journal Article
Language:	English
Published:	Hoboken, NJ Wiley 01-02-2013 Elsevier Limited
Subjects:	Adrenal Cortex Hormones - therapeutic use Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Black or African American Body Mass Index Corticosteroid withdrawal Cytomegalovirus Double-Blind Method Female Humans Hyperkalemia - metabolism kidney transplantation Kidney Transplantation - methods Kidneys Male Medical sciences Middle Aged mycophenolate mofetil Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives pharmacokinetics Pharmacology. Drug treatments Prospective Studies Renal Insufficiency - ethnology Renal Insufficiency - therapy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system tacrolimus Tacrolimus - administration & dosage Transplants & implants Mofetil Mycophenolic acid Calcineurin inhibitor Multicenter study Homotransplantation Kidney Randomization Surgery Treatment withdrawal Corticosteroid withdrawal Graft Antiviral Clinical trial Protein synthesis inhibitor Corticosteroid Enzyme IMP dehydrogenase Enzyme inhibitor Lactone Exposure Macrolide Immunomodulator Antibiotic Treatment Urinary system Tacrolimus Oxidoreductases Immunosuppressive agent Mycophenolate mofetil Inosine monophosphate dehydrogenase inhibitor Antibacterial agent Pharmacokinetics Kidney transplantation
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