The Role of Multicellular Aggregation in the Survival of ErbB2-positive Breast Cancer Cells during Extracellular Matrix Detachment

The metastasis of cancer cells from the site of the primary tumor to distant sites in the body represents the most deadly manifestation of cancer. In order for metastasis to occur, cancer cells need to evade anoikis, which is defined as apoptosis caused by loss of attachment to extracellular matrix...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 290; no. 14; pp. 8722 - 8733
Main Authors:	Rayavarapu, Raju R., Heiden, Brendan, Pagani, Nicholas, Shaw, Melissa M., Shuff, Sydney, Zhang, Siyuan, Schafer, Zachary T.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 03-04-2015 American Society for Biochemistry and Molecular Biology
Subjects:	aggregation anoikis breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor epidermal growth factor receptor (EGFR) extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Female Humans metastasis Molecular Bases of Disease Receptor, ErbB-2 - metabolism Signal Transduction anoikis breast cancer aggregation epidermal growth factor receptor (EGFR) metastasis extracellular matrix
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!