Quantitative Analysis of Energy Metabolic Pathways in MCF-7 Breast Cancer Cells by Selected Reaction Monitoring Assay

To investigate the quantitative response of energy metabolic pathways in human MCF-7 breast cancer cells to hypoxia, glucose deprivation, and estradiol stimulation, we developed a targeted proteomics assay for accurate quantification of protein expression in glycolysis/gluconeogenesis, TCA cycle, an...

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Bibliographic Details
Published in:	Molecular & cellular proteomics Vol. 11; no. 8; pp. 422 - 434
Main Authors:	Drabovich, Andrei P., Pavlou, Maria P., Dimitromanolakis, Apostolos, Diamandis, Eleftherios P.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-2012 The American Society for Biochemistry and Molecular Biology
Subjects:	Algorithms Amino Acid Sequence Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Hypoxia Cell Line Cell Proliferation - drug effects Chromatography, Liquid Citric Acid Cycle Energy Metabolism Estradiol - pharmacology Galactose - pharmacology Glucose - metabolism Glutamine - metabolism Glycolysis Humans Linear Models Mass Spectrometry MCF-7 Cells Metabolic Networks and Pathways Molecular Sequence Data Pentose Phosphate Pathway Peptides - analysis Proteome - analysis Proteomics - methods
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