OCT4 mutations in human erythroleukemic cells: implications for multiple drug resistance (MDR) phenotype

The OCT4 transcription factor is a crucial stem cells marker and it has been related to the cancer stem cells concept. Moreover, it has also been associated to the multiple drug resistance (MDR) phenotype. Our first results pointed out a straight relation between OCT4 and ABC transporters in K562-de...

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Bibliographic Details
Published in:	Molecular and cellular biochemistry Vol. 400; no. 1-2; pp. 41 - 50
Main Authors:	Oliveira, Bruno Rodrigues, Figueiredo, Marcio Azevedo, Trindade, Gilma Santos, Marins, Luis Fernando
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-02-2015 Springer Springer Nature B.V
Subjects:	Amino acids Biochemistry Biomedical and Life Sciences Cancer Cardiology Cell Line, Tumor Chemotherapy Drug resistance Drug Resistance, Multiple - genetics Gene expression Genotype & phenotype Humans Leukemia Leukemia, Erythroblastic, Acute - drug therapy Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - pathology Life Sciences Medical Biochemistry Mutation Neoplastic Stem Cells - pathology Octamer Transcription Factor-3 - genetics Oncology Phosphorylation Stem cells Transcription factors Phosphorylation motifs Transcription factors ABC transporters K562-Lucena K562 Gene expression
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