PM2.5 air pollution contributes to the burden of frailty
Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM 2.5 is associated with frailty. This cross-sectional study involved 20,606 community-dwelling participants aged ≥ 65 years, residing in New Taipei City, Taiwan. Analytic data included...
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| Published in: | Scientific reports Vol. 10; no. 1 |
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| Abstract | Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM
2.5
is associated with frailty. This cross-sectional study involved 20,606 community-dwelling participants aged ≥ 65 years, residing in New Taipei City, Taiwan. Analytic data included phenotypic frailty, disease burden by Charlson Comorbidity Index (CCI), urban or rural residence, and household income. PM
2.5
exposure was calculated from air quality monitoring records, with low exposure defined as the lowest quartile of the study population. 1,080 frail participants (5.2%) were older, predominantly female, had more comorbidities, lived rurally, and had low PM
2.5
exposure (all
p
< 0.001). In multinomial logistic regression analyses, the likelihood of high PM
2.5
exposure was higher in prefrail (OR 1.4, 95% CI 1.3–1.5) and frail adults (OR 1.5, 95% CI 1.2–1.9) than in robust individuals, with stronger associations in those who were male (frail: OR 2.1, 95% CI 1.5–3.1; prefrail: OR 2.2, 95% CI 1.9–2.6), ≥ 75 years old (frail: OR 1.8, 95% CI 1.3–2.4; prefrail: OR 1.5, 95% CI 1.3–1.8), non-smokers (frail: OR 1.6, 95% CI 1.3–2.0; prefrail: OR 1.4, 95% CI 1.2–1.5), had CCI ≥ 2 (frail: OR 5.1, 95% CI 2.1–12.6; prefrail: OR 2.1, 95% CI 1.2–3.8), and with low household income (frail: OR 4.0, 95% CI 2.8–5.8; prefrail: OR 2.7, 95% CI 2.2–3.3). This study revealed a significant association between PM
2.5
exposure and frailty, with a stronger effect in vulnerable groups. |
|---|---|
| AbstractList | Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM2.5 is associated with frailty. This cross-sectional study involved 20,606 community-dwelling participants aged ≥ 65 years, residing in New Taipei City, Taiwan. Analytic data included phenotypic frailty, disease burden by Charlson Comorbidity Index (CCI), urban or rural residence, and household income. PM2.5 exposure was calculated from air quality monitoring records, with low exposure defined as the lowest quartile of the study population. 1,080 frail participants (5.2%) were older, predominantly female, had more comorbidities, lived rurally, and had low PM2.5 exposure (all p < 0.001). In multinomial logistic regression analyses, the likelihood of high PM2.5 exposure was higher in prefrail (OR 1.4, 95% CI 1.3–1.5) and frail adults (OR 1.5, 95% CI 1.2–1.9) than in robust individuals, with stronger associations in those who were male (frail: OR 2.1, 95% CI 1.5–3.1; prefrail: OR 2.2, 95% CI 1.9–2.6), ≥ 75 years old (frail: OR 1.8, 95% CI 1.3–2.4; prefrail: OR 1.5, 95% CI 1.3–1.8), non-smokers (frail: OR 1.6, 95% CI 1.3–2.0; prefrail: OR 1.4, 95% CI 1.2–1.5), had CCI ≥ 2 (frail: OR 5.1, 95% CI 2.1–12.6; prefrail: OR 2.1, 95% CI 1.2–3.8), and with low household income (frail: OR 4.0, 95% CI 2.8–5.8; prefrail: OR 2.7, 95% CI 2.2–3.3). This study revealed a significant association between PM2.5 exposure and frailty, with a stronger effect in vulnerable groups. Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM 2.5 is associated with frailty. This cross-sectional study involved 20,606 community-dwelling participants aged ≥ 65 years, residing in New Taipei City, Taiwan. Analytic data included phenotypic frailty, disease burden by Charlson Comorbidity Index (CCI), urban or rural residence, and household income. PM 2.5 exposure was calculated from air quality monitoring records, with low exposure defined as the lowest quartile of the study population. 1,080 frail participants (5.2%) were older, predominantly female, had more comorbidities, lived rurally, and had low PM 2.5 exposure (all p < 0.001). In multinomial logistic regression analyses, the likelihood of high PM 2.5 exposure was higher in prefrail (OR 1.4, 95% CI 1.3–1.5) and frail adults (OR 1.5, 95% CI 1.2–1.9) than in robust individuals, with stronger associations in those who were male (frail: OR 2.1, 95% CI 1.5–3.1; prefrail: OR 2.2, 95% CI 1.9–2.6), ≥ 75 years old (frail: OR 1.8, 95% CI 1.3–2.4; prefrail: OR 1.5, 95% CI 1.3–1.8), non-smokers (frail: OR 1.6, 95% CI 1.3–2.0; prefrail: OR 1.4, 95% CI 1.2–1.5), had CCI ≥ 2 (frail: OR 5.1, 95% CI 2.1–12.6; prefrail: OR 2.1, 95% CI 1.2–3.8), and with low household income (frail: OR 4.0, 95% CI 2.8–5.8; prefrail: OR 2.7, 95% CI 2.2–3.3). This study revealed a significant association between PM 2.5 exposure and frailty, with a stronger effect in vulnerable groups. |
| ArticleNumber | 14478 |
| Author | Lin, Chi-Hung Chen, Liang-Kung Lee, Wei-Ju Liu, Ching-Yi Peng, Li-Ning Lin, Hui-Ping |
| Author_xml | – sequence: 1 givenname: Wei-Ju surname: Lee fullname: Lee, Wei-Ju organization: Aging and Health Research Center, National Yang Ming University, Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch – sequence: 2 givenname: Ching-Yi surname: Liu fullname: Liu, Ching-Yi organization: Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Institute of Hospital and Health Care Administration, National Yang Ming University – sequence: 3 givenname: Li-Ning surname: Peng fullname: Peng, Li-Ning organization: Aging and Health Research Center, National Yang Ming University, Center for Geriatrics and Gerontology, Taipei Veterans General Hospital – sequence: 4 givenname: Chi-Hung surname: Lin fullname: Lin, Chi-Hung organization: Department of Health, New Taipei City Government – sequence: 5 givenname: Hui-Ping surname: Lin fullname: Lin, Hui-Ping organization: Department of Health, New Taipei City Government – sequence: 6 givenname: Liang-Kung surname: Chen fullname: Chen, Liang-Kung email: lkchen2@vghtpe.gov.tw organization: Aging and Health Research Center, National Yang Ming University, Center for Geriatrics and Gerontology, Taipei Veterans General Hospital |
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| Cites_doi | 10.1289/ehp.1307301 10.3200/AEOH.60.6.307-313 10.1016/j.jamda.2017.12.015 10.33879/AMH.2019.1727 10.1016/s0140-6736(12)62167-9 10.1289/ehp.0800194 10.1002/gps.1314 10.1038/srep46417 10.1249/01.MSS.0000078924.61453.FB 10.1038/s41598-018-32537-5 10.1016/j.jamda.2013.11.025 10.1016/s0140-6736(17)32345-0 10.3390/ijerph15112608 10.1093/aje/kws001 10.1016/j.ijheh.2015.12.002 10.1371/journal.pone.0008775 10.1097/MD.0000000000004661 10.1371/journal.pone.0161456 10.1016/j.jacc.2014.01.026 10.1111/ggi.12129 10.1136/bmjopen-2015-010802 10.1016/j.cger.2010.08.006 10.1093/ageing/afy169 10.1016/j.archger.2017.11.001 10.1289/ehp.1409276 10.1016/j.annepidem.2013.05.001 10.1038/srep40427 10.1007/s11357-015-9762-4 10.1016/j.jacc.2018.07.099 10.1016/j.arr.2015.09.004 10.1093/gerona/56.3.M146 |
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| Snippet | Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM
2.5
is associated with frailty. This... Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM2.5 is associated with frailty. This... |
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| SubjectTerms | 692/1807 692/308 692/499 Air pollution Clinical trials Humanities and Social Sciences multidisciplinary Occlusion Science Science (multidisciplinary) |
| Title | PM2.5 air pollution contributes to the burden of frailty |
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