Alteration of PPAR‐GAMMA (PPARG; PPARγ) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPARγ stimulation using pioglitazone on AML cells

Background In the new era of tailored cancer treatment strategies, finding a molecule to regulate a wide range of intracellular functions is valuable. The unique property of nuclear receptor peroxisome proliferator‐activated receptor‐γ (PPARγ; PPARG) in transmitting the anti‐survival signals of the...

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Bibliographic Details
Published in:	Molecular genetics & genomic medicine Vol. 9; no. 11; pp. e1818 - n/a
Main Authors:	Esmaeili, Shadi, Salari, Sina, Kaveh, Vahid, Ghaffari, Seyed H., Bashash, Davood
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-11-2021 John Wiley and Sons Inc Wiley
Subjects:	Acute myeloid leukemia Anticancer properties Apoptosis Cancer Carrier Proteins Cell culture Cell cycle Flow cytometry G1 phase Gene Expression Humans Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Ligands Medical research Myeloid leukemia Original Patients Peroxisome proliferator-activated receptors peroxisome proliferator‐activated receptor‐γ Pioglitazone Pioglitazone - pharmacology PPAR gamma - genetics PPARγ PTEN PTEN Phosphohydrolase - genetics PTEN protein Receptors Statistical analysis Statistical methods Stimulation Survival Thermal cycling U937 Cells PTEN peroxisome proliferator-activated receptor-γ pioglitazone acute myeloid leukemia PPARγ
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