Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone

Aim The efficacy and safety of canagliflozin, a sodium glucose co‐transporter 2 inhibitor, was evaluated in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and pioglitazone. Methods In this randomized, double‐blind, phase 3 study, patients (N = 342) received cana...

Full description

Saved in:

Bibliographic Details
Published in:	Diabetes, obesity & metabolism Vol. 16; no. 5; pp. 467 - 477
Main Authors:	Forst, T., Guthrie, R., Goldenberg, R., Yee, J., Vijapurkar, U., Meininger, G., Stein, P.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-05-2014 Wiley Subscription Services, Inc
Subjects:	Antidiabetics Blood Glucose - drug effects Blood Glucose - metabolism Blood pressure Blood Pressure - drug effects Body weight Canagliflozin Candidiasis - chemically induced Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diuresis Diuretics, Osmotic - adverse effects Double-Blind Method Drug therapy Drug Therapy, Combination Female Genital Diseases, Female - chemically induced Genital Diseases, Male - chemically induced Glucose transporter Glucosides - administration & dosage Glucosides - adverse effects Glucosides - therapeutic use Hemoglobin Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Lipids Male Metformin Metformin - administration & dosage Middle Aged Original phase 3 study Pioglitazone Placebos Pyrazines - administration & dosage Safety SGLT2 inhibitor Sitagliptin Phosphate thiazolidinediones Thiazolidinediones - administration & dosage Thiophenes - administration & dosage Thiophenes - adverse effects Thiophenes - therapeutic use Treatment Outcome Triazoles - administration & dosage type 2 diabetes Weight Loss thiazolidinediones metformin type 2 diabetes phase 3 study SGLT2 inhibitor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!