Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro
Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication in vitro. Three of nine new synth...
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| Published in: | Vaccine Vol. 15; no. 12; pp. 1479 - 1486 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford
Elsevier Ltd
01-08-1997
Elsevier |
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| Abstract | Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication
in vitro. Three of nine new synthetic MDP derivatives (β-butyl-MDP, MTPO-26 and β-cholesteryl-MDP) and one saponin (Taurosid I) have been shown to induce strong humoral immune responses to HIV-1 envelope glycoproteins rgp160 and rgp120. Three substances (β-butyl-MDP, MDP-cholyl and β-G27-MDP) induced high levels of T-cell stimulation to HIV-1 rgp160. β-butyl-MDP induced the strongest B- and T-cell responses to HIV-1 glycoproteins. Two substances (β-butyl-MDP and Taurosid I) did not induce an enhancement of HIV-1 replication
in vitro and can be considered as promising adjuvants. |
|---|---|
| AbstractList | Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication
in vitro. Three of nine new synthetic MDP derivatives (β-butyl-MDP, MTPO-26 and β-cholesteryl-MDP) and one saponin (Taurosid I) have been shown to induce strong humoral immune responses to HIV-1 envelope glycoproteins rgp160 and rgp120. Three substances (β-butyl-MDP, MDP-cholyl and β-G27-MDP) induced high levels of T-cell stimulation to HIV-1 rgp160. β-butyl-MDP induced the strongest B- and T-cell responses to HIV-1 glycoproteins. Two substances (β-butyl-MDP and Taurosid I) did not induce an enhancement of HIV-1 replication
in vitro and can be considered as promising adjuvants. Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication in vitro. Three of nine new synthetic MDP derivatives (beta-butyl-MDP, MTPO-26 and beta-cholesteryl-MDP) and one saponin (Taurosid I) have been shown to induce strong humoral immune responses to HIV-1 envelope glycoproteins rgp160 and rgp120. Three substances (beta-butyl-MDP, MDP-cholyl and beta-G27-MDP) induced high levels of T-cell stimulation to HIV-1 rgp160. beta-butyl-MDP induced the strongest B- and T-cell responses to HIV-1 glycoproteins. Two substances (beta-butyl-MDP and Taurosid I) did not induce an enhancement of HIV-1 replication in vitro and can be considered as promising adjuvants. Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication in vitro. Three of nine new synthetic MDP derivatives ( beta -butyl-MDP, MTPO-26 and beta -cholestelyl-MDP) and one saponin (Taurosid I) have been shown to induce strong humoral immune responses to HIV-1 envelope glycoproteins rgp160 and rgp120. Three substances ( beta -butyl-MDP, MDP-cholyl and beta -G27-MDP) induced high levels of T-cell stimulation to HIV-1 rgp160. beta -butyl-MDP induced the strongest B- and T-cell responses to HIV-1 glycoproteins. Two substances ( beta -butyl-MDP and Taurosid I) did not induce an enhancement of HIV-1 replication in vitro and can be considered as promising adjuvants. |
| Author | Zemlyakov, Alexander E. Pertel, Sergey S. Krivorutchenko, Yuri L. Wahren, Britta Krivoshein, Yuri S. Ljungdahl-Ståhle, Ewa Hinkula, Jorma Andronovskaja, Irina B. Grishkovets, Vladimir I. |
| Author_xml | – sequence: 1 givenname: Yuri L. surname: Krivorutchenko fullname: Krivorutchenko, Yuri L. organization: Department of Microbiology and Virology, Crimean Medical Institute, Lenina Boulevard 5/7, 333670 Simferopol, Crimea, Ukraine – sequence: 2 givenname: Irina B. surname: Andronovskaja fullname: Andronovskaja, Irina B. organization: Department of Microbiology and Virology, Crimean Medical Institute, Lenina Boulevard 5/7, 333670 Simferopol, Crimea, Ukraine – sequence: 3 givenname: Jorma surname: Hinkula fullname: Hinkula, Jorma organization: Department of Virology, Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden – sequence: 4 givenname: Yuri S. surname: Krivoshein fullname: Krivoshein, Yuri S. organization: Department of Microbiology and Virology, Crimean Medical Institute, Lenina Boulevard 5/7, 333670 Simferopol, Crimea, Ukraine – sequence: 5 givenname: Ewa surname: Ljungdahl-Ståhle fullname: Ljungdahl-Ståhle, Ewa organization: Department of Virology, Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden – sequence: 6 givenname: Sergey S. surname: Pertel fullname: Pertel, Sergey S. organization: Department of Organic Chemistry, Simferopol State University, Yaltinskaja str.4, 333036 Simferopol, Crimea, Ukraine – sequence: 7 givenname: Vladimir I. surname: Grishkovets fullname: Grishkovets, Vladimir I. organization: Department of Organic Chemistry, Simferopol State University, Yaltinskaja str.4, 333036 Simferopol, Crimea, Ukraine – sequence: 8 givenname: Alexander E. surname: Zemlyakov fullname: Zemlyakov, Alexander E. organization: Department of Organic Chemistry, Simferopol State University, Yaltinskaja str.4, 333036 Simferopol, Crimea, Ukraine – sequence: 9 givenname: Britta surname: Wahren fullname: Wahren, Britta organization: Department of Virology, Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden |
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| Keywords | HIV-1 muramyl dipeptide derivatives adjuvants saponins Immunopathology Immunostimulation HIV-1 virus Rodentia Retroviridae AIDS Vaccine Immune deficiency Saponin Infection Virus Vertebrata Mammalia Immunogenicity Mouse Viral disease Immunological adjuvant In vitro replication Lentivirinae Human immunodeficiency virus Inhibition Humoral immunity |
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| Snippet | Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in... |
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| SubjectTerms | Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives Acetylmuramyl-Alanyl-Isoglutamine - pharmacology adjuvants Adjuvants, Immunologic - pharmacology AIDS/HIV Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology HIV-1 HIV-1 - drug effects HIV-1 - physiology human immunodeficiency virus 1 Male Medicin och hälsovetenskap Mice Mice, Inbred BALB C Microbiology muramyl dipeptide derivatives saponins Saponins - pharmacology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology Virus Replication - drug effects |
| Title | Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro |
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